Really awesome article on the effects of thorazine and clozaril on grey matter and white matter:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3476840/
In it, there is a small truth to what Cory and Susan insist about clozaril: in the smallest doses - under 111 mg / day - anti psychotics can seem to ward off the brain mass reduction that happens naturally over time with schizophrenia. However, in doses larger than this, the brain mass declines rapidly, more so than the disease causes alone. The higher the doses, the more pronounced the brain deterioration is.
Jani takes 300 mgs of clozaril plus 75 mg of thorazine. If counts lithium among the antipsychotics in this study - she takes 900 mg / day of lithium, so 1275 mg of anti psychotic meds total - Jani is in the "highest treatment level" group (taking over 900 mg combined of anti psychotics / day), with the highest brain deteriorating effects. Bodhi is already on 300 mg of thorazine per day, and I think when Susan last crowed about it, his clozaril was at 50-75 / day. So he's already in the mid-level treatment, per this study.
In the study, rhesus monkeys were given thorazine and clozaril, and within 27 months, they had lost 8-11% of their brain weight, most of it in the frontal lobe and prefrontal cortex (i.e. places that you use for reasoning.) That's loss without the addition of schizophrenia.
In short: Susan has melted Jani's brain, an autistic child who was once very vivacious and creative, if weird.