Nah,
estrogen is a neuroactive steroid. Takes a little longer for gene expression to change, but if you're a guy with normal hormone levels and you hit your system with a big dose of estrogen, it's no surprise if you feel different pretty quickly.
Bonus cryptohorny troon post so I'm not just sperging about endocrinology
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Ah yes, puberty, the time of life that every true and honest woman is nostalgic about. Note the "girly" username, and also note that transition and dress-wearing isn't about becoming a woman, it's about living the fantasy of being a cool teenage girl. Because that's what women love to do, publically cosplay as their teensona!
Women rightfully pity and look down on an adult women who dresses and acts like a teenager, even (especially!) if she's trying to recapture a time of life she feels she missed out on. But of course this particular social subtlety would never penetrate the autistic troon brain.