Wuhan Coronavirus - COVID-19 Analysis & Summary - This is not just fucking pneumonia. It is everything but the kitchen sink. Lungs, heart, kidneys, liver, brain, blood vessels, testes. It affects them all.

more shows up in the results, but he's gone either gone full DFE or he's renaming accounts
Oh he's definitely going full DFE. He was even bragging about it in chat yesterday (kudos to @Spedestrian for grabbing this):
Drain_Todger_6_nobodyexpectsthezed.png

 
Dave, Can I call you Dave? You did a dumb dumb. Next time please concider not doing something stupid.

Duly noted.

Now, let's get down to brass tacks.

I predict that sometime in Mid-April or perhaps May, if we don't implement full isolation between now and then, we'll see suspension of Posse Comitatus and the use of US Army and Marines to enforce quarantines with manpower the National Guard cannot match.



It is possible it could be avoided, if everyone just stays home for the next month or so and stops going out and getting sick. We'll see.

Where has the claim the Virus has the same receptor paths as the HIV virus come from? I keep seeing this pop up but I dont know how true it is or why it's even a rumor.

Nope. It uses the same entry receptor as SARS: ACE2.

ACE2 stands for Angiotensin Converting Enzyme 2.


Normally, Angiotensin II is catalyzed by ACE2 and converts into Angiotensin 1-7.



Angiotensin 1-7 is a Mas receptor agonist.


This normal route, Ang II > ACE2 > Ang 1-7 > MasR is anti-inflammatory and vasodilatory.

Now, what happens when the virus uses up ACE2 as its entry receptor? Well, instead, Ang II builds up and activates AT1R.


The AT1 receptor mediates the major cardiovascular effects of angiotensin II. Effects include vasoconstriction, aldosterone synthesis and secretion, increased vasopressin secretion, cardiac hypertrophy, augmentation of peripheral noradrenergic activity, vascular smooth muscle cells proliferation, decreased renal blood flow, renal renin inhibition, renal tubular sodium reuptake, modulation of central sympathetic nervous system activity, cardiac contractility, central osmocontrol and extracellular matrix formation.

This has the opposite effect. Vasoconstriction, inflammation, electrolytic imbalance, and so on.

Because of the virus using ACE2 as its entry receptor, the renin-angiotensin-aldosterone system is thrown out of balance.

Do you know what this does? This sends inflammatory cytokines into your tissues, it can aggravate hypertension, oh, and it can also cause hypokalemia, or low blood potassium:




Normally, the RAAS system uses a delicate dance of hormones to make sure your blood pressure and intracellular levels of sodium and potassium are correct. COVID-19 is an enormous monkey wrench thrown into that entire process, and that's just one of the ways it causes damage.

The other way it causes damage, other than helping bacteria infect you, is mostly hypoxemia from the pneumonia and ARDS. The low blood O2 saturation causes multiple organ damage on top of the inflammation. Your organs need oxygenated blood to stay alive, to put it quite simply.

The claim of the virus having an HIV-like nature comes from the fact that SARS-CoV-2 has a unique mutation where the S protein has furin cleavage sites. These articles explain it quite well:





This property makes it far more infectious than SARS. In fact, the defining aspect of SARS-CoV-2 is that it is basically a form of SARS with very efficient spikes that enable rapid human-to-human transmission.
 
Duly noted.

Now, let's get down to brass tacks.

I predict that sometime in Mid-April or perhaps May, if we don't implement full isolation between now and then, we'll see suspension of Posse Comitatus and the use of US Army and Marines to enforce quarantines with manpower the National Guard cannot match.



It is possible it could be avoided, if everyone just stays home for the next month or so and stops going out and getting sick. We'll see.



Nope. It uses the same entry receptor as SARS: ACE2.

ACE2 stands for Angiotensin Converting Enzyme 2.


Normally, Angiotensin II is catalyzed by ACE2 and converts into Angiotensin 1-7.



Angiotensin 1-7 is a Mas receptor agonist.


This normal route, Ang II > ACE2 > Ang 1-7 > MasR is anti-inflammatory and vasodilatory.

Now, what happens when the virus uses up ACE2 as its entry receptor? Well, instead, Ang II builds up and activates AT1R.




This has the opposite effect. Vasoconstriction, inflammation, electrolytic imbalance, and so on.

Because of the virus using ACE2 as its entry receptor, the renin-angiotensin-aldosterone system is thrown out of balance.

Do you know what this does? This sends inflammatory cytokines into your tissues, it can aggravate hypertension, oh, and it can also cause hypokalemia, or low blood potassium:




Normally, the RAAS system uses a delicate dance of hormones to make sure your blood pressure and intracellular levels of sodium and potassium are correct. COVID-19 is an enormous monkey wrench thrown into that entire process, and that's just one of the ways it causes damage.

The other way it causes damage, other than helping bacteria infect you, is mostly hypoxemia from the pneumonia and ARDS. The low blood O2 saturation causes multiple organ damage on top of the inflammation. Your organs need oxygenated blood to stay alive, to put it quite simply.

The claim of the virus having an HIV-like nature comes from the fact that SARS-CoV-2 has a unique mutation where the S protein has furin cleavage sites. These articles explain it quite well:





This property makes it far more infectious than SARS. In fact, the defining aspect of SARS-CoV-2 is that it is basically a form of SARS with very efficient spikes that enable rapid human-to-human transmission.
You got doxed as a complete and utter sperg that fantasizes about fucking horses and who is too retarded to do any research or get when people are done with you given you can't sort information by relevence and YOU'RE STILL DOOMPOSTING HERE.

Amazing. Absolutely amazing.
 
I see you updated your Fanfiction.net account recently. Could you un-delete those Powerpuff Girls fanfictions you wrote? We would all love to read them.

I’m Train Dodger. I don’t need a big, long-winded bio. You don’t need to know anything about me. I’m just about the most horrible person who ever lived. I’m not going to glitter-bomb you with 16-year-old schoolgirl nonsense. I’m not going to tell you all about my OCs and how speshul they are. I’m not going to tell you about my litany of mental issues and how you need to kiss my ass because of them. Just read the damn stories and comment if you like ’em. Or don’t, and save your sanity.
When I was 11, I wrote cringy Powerpuff Girls script-fics. When I was 16, I wrote a godawful Halo fic that was only notable because I somehow cranked out a 10-kiloword chapter of it in a day, but it was all trash anyway. No, you can’t read it. I deleted all that garbage. Now that I’m going on my thirties, I write very, very depressing things that are precision-engineered to make you nauseous and choked-up. Welcome to the wasteland, suckas.
My Fimfiction profile: https:///user/62643/TrainDodger
 
Duly noted.

Now, let's get down to brass tacks.

I predict that sometime in Mid-April or perhaps May, if we don't implement full isolation between now and then, we'll see suspension of Posse Comitatus and the use of US Army and Marines to enforce quarantines with manpower the National Guard cannot match.



It is possible it could be avoided, if everyone just stays home for the next month or so and stops going out and getting sick. We'll see.



Nope. It uses the same entry receptor as SARS: ACE2.

ACE2 stands for Angiotensin Converting Enzyme 2.


Normally, Angiotensin II is catalyzed by ACE2 and converts into Angiotensin 1-7.



Angiotensin 1-7 is a Mas receptor agonist.


This normal route, Ang II > ACE2 > Ang 1-7 > MasR is anti-inflammatory and vasodilatory.

Now, what happens when the virus uses up ACE2 as its entry receptor? Well, instead, Ang II builds up and activates AT1R.




This has the opposite effect. Vasoconstriction, inflammation, electrolytic imbalance, and so on.

Because of the virus using ACE2 as its entry receptor, the renin-angiotensin-aldosterone system is thrown out of balance.

Do you know what this does? This sends inflammatory cytokines into your tissues, it can aggravate hypertension, oh, and it can also cause hypokalemia, or low blood potassium:




Normally, the RAAS system uses a delicate dance of hormones to make sure your blood pressure and intracellular levels of sodium and potassium are correct. COVID-19 is an enormous monkey wrench thrown into that entire process, and that's just one of the ways it causes damage.

The other way it causes damage, other than helping bacteria infect you, is mostly hypoxemia from the pneumonia and ARDS. The low blood O2 saturation causes multiple organ damage on top of the inflammation. Your organs need oxygenated blood to stay alive, to put it quite simply.

The claim of the virus having an HIV-like nature comes from the fact that SARS-CoV-2 has a unique mutation where the S protein has furin cleavage sites. These articles explain it quite well:





This property makes it far more infectious than SARS. In fact, the defining aspect of SARS-CoV-2 is that it is basically a form of SARS with very efficient spikes that enable rapid human-to-human transmission.


Is this thread your personal Corona fanfic now?
 
You got doxed as a complete and utter sperg that fantasizes about fucking horses and who is too exceptional to do any research or get when people are done with you given you can't sort information by relevence and YOU'RE STILL DOOMPOSTING HERE.

Amazing. Absolutely amazing.
It's amazing right? Absolutely heroic levels of autism. Who said nothing good came out of this pandemic?

This thread has it all. I hope future historians read it some day.
 
Back