Mainly false negatives.
I know, it’s an insanely low accuracy isn’t it?
For those non laboratory kiwis - rtPCR and PCR in general is extremely sensitive. You can pick up single copies of sequence and if you’re good, you can use a single cell as a start point. A swab should have loads of viral material All over it. For the tests to be so shitty is unusual. Some maybes:
- nasal and throats swabs I’m hearing can be negative when a deeper sample (broncho alveolar sample or coughed up sputum) can be positive
- RNA degrades fast - the swabs get dunked in a stabiliser. Maybe that’s not working well
- maybe the primers aren’t so good?
- crap batch of polymerase? Probably not if the controls are coming up
- false positives - kits contaminated with corona sequence.
-primers cross a divergent sequence and are not picking up different strains (pretty unlikely, it’s be likely that this would be picked up because it would be clustered locally, I’m just spitballing for possible reasons WHY these tests are so crap.)
Archive of abstract:
https://archive.li/EAjAN
the actual pdf:
https://www.medrxiv.org/content/10.1101/2020.02.11.20021493v2.full.pdf
Can someone archive this (apologies on phone)
lots of false negatives:
https://www.livescience.com/covid19-coronavirus-tests-false-negatives.html
Archive:
archived 4 Apr 2020 19:27:03 UTC
archive.li
One other thing I’m seeing people say is that the Wuhan lab was putting out an ad a few months ago for a post to study a newly discovered bar virus. Nobody has given any source, but I’ve heard it a few times. Do we have a source for that? Something for our rune-literate kiwis to look for?
eodted to avoid double post:
@EmuWarsVeteran what’s the deal with the primers? Are we still using the ones the Chinese told us to or are people designing their own? Using nested primers? It throws up some interesting thoughts of it’s a primer problem