In the situation that kid lives in is the perfect storm for exploitation and abuse. His biological parents are gone, for one. His grandmother seems unstable being the way she is (some mental illness, possible substance abuse, incapable of maintaining a pet, incapable of booting out a useless adult son, etc). His crazy uncle probably terrifies him with the mood swings, disgusting habits, enormous size and smell. Guarantee you Lou pitches a psychotic temper tantrum at the kid if he so much as touches one of his Uncle's toys.
Lou has a history of being deep into that MLP fad from a few years back, which always struck me as being pedophilic in nature.... sexualizing cartoon characters and toys that were clearly initially intended for children. MLP wasn't something created by furries for furry purposes-- it was originally a children's show intended for children. Validating his weird personal sexual identities is one of Lou's primary personality traits. Using others for his own personal benefit and pleasure is another trait of Lou's, and I'm sure he'd be more than happy to exploit a vulnerable child to get his needs met-- whether it's to grift in order to get more money, someone to manipulate for one's own purposes, a tool to get some toy/game/DVD Lou personally wants for himself (what 6 year old today watches Charlie Brown TV specials?), or something far worse.
My big concern is how Lou name flippantly drops how his dad supposedly raped him as a child. I tend to give people the benefit of the doubt when they make these claims, but something about it just strikes me as "off".... Then he whines about being a virgin. Most rape victims don't call themselves "virgins"-- they'll say their virginity was stolen by a rapist if they make a reference to it at all, but they won't call themselves virgins. I could see someone with his kind of personality using some bizarre contorted thought process to justify child abuse he himself commits, claiming sex acts aren't really "sex".
Even IF this story about Lou being raped by his deceased father is true, that only goes to show you that his mother is oblivious to what goes on to children who are under her care. If Lou's father had the time and opportunity to rape Lou as a child with Lou's mother in the house, Lou could probably be doing or saying all sorts of crazy shit to that poor child and "Grandma" would be just as oblivious. Not saying the blame would all be on her, but it just shows you she doesn't always see red flags that are waving in front of her face.
Much of what Lou says online is pure projection, which also makes me more afraid for the nephew. What if it's not really Lou's father who raped him, but Lou himself actually doing it to another child? He often accuses his mother of doing things to him that he is actually guilty of. There are tons of other examples on this thread that include him accusing someone of doing something that he himself does all the time. If he comes across as arrogant and obnoxious IRL as he does online, I guarantee you that child is exposed to tons of emotional abuse at the very least. When you're a kid exposed to a crazy parental figure's outburst and mind games, you often don't have the "rank" to call them out when they act like abusive ogres to you. Lou, as an Uncle, is probably someone of whom the nephew "has to respect". If the kid tattled on his Uncle for being an ogre, the kid himself would probably be punished by both the Uncle and the grandmother. Kids in situations like his often remain quiet because they have no allies to stick up for them.
Lou spends so much time writing messed up shit online, he could be doing a lot in that house without getting "caught". Plenty of people get away with child abuse. His nephew probably knows he could easily wind up in foster care (considering his parents already abandoned him), so he probably won't "narc".
LOUMAN SHIELD ACTIVATED! 
