I think the only flaw with Mr House is that he loves the sound of his own voice and he has some creepy subtext to his existence inside his pen house. Besides, I always wondered how his tech was keeping him "alive" (he looks worse than a ghoul) and how said tech would keep him alive for many many more years? Mr House doesnt seem to have any back up plans in the "unlikely" chance of his own demise...tho maybe its intentional, if he isnt around, New Vegas might as well fall apart as its no concern of his anymore.
Also it kind of hit me, Fallout 4 established that cryogenics exists so one is to wonder why that never crossed Mr House's mind. One could throw the argument that it was extremely experimental (and Vault tec had a bunch of expandable residents) and Mr House didnt want to risk it possibly backfiring?