The Todger's (pbuh) autistic studies narrowed this down somewhat, it's related to vascular functioning, so if you have high levels of inflammation or your cells/blood vessels aren't the healthiest, you're at much greater risk of complications. Being fat is like constantly being in an inflammatory state, so that's why there is such a high correlation. Additionally, having immune system issues (whether overactive conditions/disorders or immunosuppression) greatly increases your risk.
@Drain Todger probably has some more aggregated info in his pocket.
It’s not just inflammation. It’s how well the body handles calcium, iron, and redox equilibrium as well.
SARS-CoV-2 is a viral vascular endotheliitis, not a viral pneumonia. It causes pneumonia from the inside of the blood vessels outwards, by compromising the blood-air barrier directly and causing pulmonary edema. That is, fluid leakage from the capillaries and into the alveoli in the lungs. The ACE2 protein is strongly expressed in the lining of the blood vessels, and this is why COVID-19 appears to affect every organ; all organs are vascularized.
The main pre-existing condition that worsens COVID-19 is Endothelial Dysfunction. Obesity can cause endothelial dysfunction.
Obesity dramatically increases the risk of development of cardiovascular and metabolic diseases. Endothelial dysfunction induced by obesity is an important risk factor that impairs blood flow controls in various organs. Impaired endothelial function occurs early in life in obese children. Obesity-induced endothelial dysfunction is associated with decreased nitric oxide (NO) production due to impaired endothelial NO synthase activity and expression and increased production of superoxide anion and the endogenous NOS inhibitor ADMA, together with increased vasoconstrictor factors, such as endothelin-1 and sympathetic nerve activation.
Vitamin D deficiency will give someone endothelial dysfunction over time. 80% of African-Americans have Vitamin D deficiency and many have endothelial dysfunction as a direct consequence (on top of genetic variations in nitric oxide synthase behavior):
Vitamin D is known to elicit a vasoprotective effect, while vitamin D deficiency is a risk factor for endothelial dysfunction (ED). ED is characterized by reduced bioavailability of a potent endothelium-dependent vasodilator, nitric oxide (NO), and is an early event in the development of atherosclerosis. In endothelial cells, vitamin D regulates NO synthesis by mediating the activity of the endothelial NO synthase (eNOS). Under pathogenic conditions, the oxidative stress caused by excessive production of reactive oxygen species (ROS) facilitates NO degradation and suppresses NO synthesis, consequently reducing NO bioavailability. Vitamin D, however, counteracts the activity of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase which produces ROS, and improves antioxidant capacity by enhancing the activity of antioxidative enzymes such as superoxide dismutase.
Nitric Oxide is a vasodilator, it acts as a crucial signaling molecule in many biological processes because it diffuses easily through the phospholipid bilayer membrane of cells, it scavenges superoxide radicals, and it is also potentially antiviral against SARS-like coronaviruses, inhibiting the palmitoylation of the Spike protein and making it less sticky.
According to preliminary research conducted in vitro, nitric oxide may help suppress SARS-CoV-2, the virus that causes COVID-19.
www.medicalnewstoday.com
Nitric oxide is an important molecule playing a key role in a broad range of biological process such as neurotransmission, vasodilatation and immune responses. While the anti-microbiological properties of nitric oxide-derived reactive nitrogen intermediates (RNI) such as peroxynitrite, are...
pubmed.ncbi.nlm.nih.gov
A paper showed that it did this in SARS, but the mechanisms of NO’s potential antiviral activity against SARS-CoV-2 may not have been fully characterized, yet.
NO is produced by the Nitric Oxide Synthase enzyme and consumed in less than six seconds. As a dissolved gas that readily reacts with reactive oxygen species, it cannot be stockpiled by the body. Endothelial NOS must produce NO continuously. When someone gets sick with COVID-19, the virus’s metabolic shifts draw tons of calcium into the cells, which start spewing superoxide as a result. This superoxide reacts with nitric oxide and forms peroxynitrite, a reactive nitrogen species. Peroxynitrite is not antiviral against SARS-like viruses. It also injures mitochondria and decouples NOS by destroying the BH4 cofactor that it needs to make nitric oxide. When NOS is uncoupled, it spits out more superoxide, creating a feedback loop that Dr. Martin L. Pall has termed NO/ONOO- disease, after the formulas for Nitric Oxide and Peroxynitrite, respectively. NADPH oxidase makes superoxide, superoxide reacts with nitric oxide and makes peroxynitrite, peroxynitrite reacts with tetrahydrobiopterin and uncoupled nitric oxide synthase, uncoupled nitric oxide synthase makes superoxide, superoxide reacts with nitric oxide to make more peroxynitrite, and this goes on in a loop. The inflammation also suppresses NOS itself.
The net effect of this is the loss of endothelial nitric oxide bioavailability, something that is known to happen in COVID-19. The presence of nitrotyrosine in assays of samples is basically proof positive that this is happening:
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is involved in a global outbreak affecting millions of people who manifest a variety of s…
www.sciencedirect.com
So, now that NO is gone, there’s a lot less to get in Superoxide’s way. So, with the help of neutrophils wigging out and spewing their enzymes everywhere through NETosis, superoxide forms downstream radicals. Hydrogen peroxide, hypochlorous acid, and hydroxyl radicals, to be precise. Hypochlorous acid in excess can strip iron out of heme, and unliganded iron greatly accelerates hydroxyl radical formation.
Multi-system involvement and rapid clinical deterioration are hallmarks of coronavirus disease 2019 (COVID-19) related mortality. The unique clinical phenomena in severe COVID-19 can be perplexing, and they include disproportionately severe hypoxemia ...
www.ncbi.nlm.nih.gov
Being obese raises ACE2 expression, lowers nitric oxide levels, and makes one more susceptible to severe inflammatory responses.
So, on to what all this means.
One, you need to raise your Vitamin D levels to the normal range with supplementation if they aren’t already. A very substantial number of people in developed countries are Vitamin D deficient anyway, so this is a good thing to try. 5000 IU a day for a while ought to do it.
Two, you need to raise your selenium and cysteine levels, promoting selenium and glutathione and their antioxidant enzyme activity (some enzymes use them as substrates to break down ROS). You should also try turmeric supplements because they activate Nrf2 and are profoundly antioxidant.
Three, avoid excess dietary iron. Shift from eating red meat to eating leafy greens and fish (which are supportive of vascular health; watch out for mercury, though). Yes, I know this is bullshit. I love a good steak, myself. But running closer to iron deficiency (but not to the point of anemia) may actually be protective. COVID-19’s final stage involves a great deal of iron overload and subsequent redox issues.
Iron overload is increasingly implicated as a contributor to the pathogenesis of COVID-19. Indeed, several of the manifestations of COVID-19, such as …
www.sciencedirect.com
Four, exercise a lot. Exercise strengthens the blood vessels, promotes the function of your own antioxidant enzymes, and reverses endothelial dysfunction.
I keep seeing trials where they stuff Vitamin D and other supplements into people who are already sick, and then declare, quite prematurely, that they don’t cure COVID-19 when they see no difference in their time to recovery and discharge. It’s completely absurd that they would do this. The cure is the long-term physiological and metabolic shifts that accompany a healthy diet (including supplements, as necessary) and lots of exercise. Pumping Vitamin D into someone lying in an ICU with endothelial dysfunction and a virus ravaging their blood vessels won’t do jack shit. You can’t miraculously undo endothelial dysfunction overnight. It’s a long-term result of exercise and a balanced diet.
Now that you mention it, I developed one too.
I just assumed it's the assloads of allergy medicine im on giving me constant headaches because everyone kept bitching about the cough i always had now, but...
I have some bad news, friend.
Growing evidence suggests that the coronavirus causes ‘brain fog’ and other neurological symptoms through multiple mechanisms.
www.nature.com
How COVID-19 damages the brain is becoming clearer. New evidence suggests that the coronavirus’s assault on the brain could be multipronged: it might attack certain brain cells directly, reduce blood flow to brain tissue or trigger production of immune molecules that can harm brain cells.
Infection with the coronavirus SARS-CoV-2 can cause memory loss, strokes and other effects on the brain. The question, says Serena Spudich, a neurologist at Yale University in New Haven, Connecticut, is: “Can we intervene early to address these abnormalities so that people don’t have long-term problems?”
With so many people affected — neurological symptoms appeared in 80% of the people hospitalized with COVID-19 who were surveyed in one study1 — researchers hope that the growing evidence base will point the way to better treatments.
SARS-CoV-2 may cause acute respiratory disease, but the infection can also initiate neurological symptoms. Here we show that SARS-CoV-2 infection causes brain inflammation in the macaque model. An increased metabolic activity in the pituitary gland of two macaques was observed by longitudinal...
www.biorxiv.org
SARS-CoV-2 may cause acute respiratory disease, but the infection can also initiate neurological symptoms. Here we show that SARS-CoV-2 infection causes brain inflammation in the macaque model. An increased metabolic activity in the pituitary gland of two macaques was observed by longitudinal positron emission tomography-computed tomography (PET-CT). Post-mortem analysis demonstrated infiltration of T-cells and activated microglia in the brain, and viral RNA was detected in brain tissues from one animal. We observed Lewy bodies in brains of all rhesus macaques. These data emphasize the virus’ capability to induce neuropathology in this nonhuman primate model for SARS-CoV-2 infection. As in humans Lewy body formation is an indication for the development of Parkinson’s disease, this data represents a warning for potential long-term neurological effects after SARS-CoV-2 infection.
First cases that point at a correlation between SARS-CoV-2 infections and the development of Parkinson’s disease have been reported. Currently it is unclear if there also is a direct causal link between these diseases. To obtain first insights into a possible molecular relation between viral...
www.biorxiv.org
First cases that point at a correlation between SARS-CoV-2 infections and the development of Parkinson’s disease have been reported. Currently it is unclear if there also is a direct causal link between these diseases. To obtain first insights into a possible molecular relation between viral infections and the aggregation of α-synuclein protein into amyloid fibrils characteristic for Parkinson’s disease, we investigated the effect of the presence of SARS-CoV-2 proteins on α-synuclein aggregation. We show, in test tube experiments, that SARS-CoV-2 S-protein has no effect on α-synuclein aggregation while SARS-CoV-2 N-protein considerably speeds up the aggregation process. We observe the formation of multi-protein complexes, and eventually amyloid fibrils. Microinjection of N-protein in SHSY-5Y cells disturbed the α-synuclein proteostasis and increased cell death. Our results point toward direct interactions between the N-protein of SARS-CoV-2 and α-synuclein as molecular basis for the observed coincidence between SARS-CoV-2 infections and Parkinsonism.
People who had been hospitalised and put on a ventilator saw the biggest deficit in the Great British Intelligence Test - equivalent to a seven-point drop in IQ.
news.sky.com
Scientists tested 81,337 people between January and December last year as part of the Great British Intelligence Test, including almost 13,000 who had been infected with the virus.
Those who had been on ventilators saw the biggest deficit - equivalent to a seven-point drop.
Apparently, SARS-CoV-2 is indeed neuroinvasive and attacks brain astrocytes, induces Lewy body formation in the brains of macaques, and has amyloidogenic proteins. Can it cause early-onset dementia, Alzheimer’s, or Parkinson’s? We don’t know.
Background Dementia-like cognitive impairment is an increasingly reported complication of SARS-CoV-2 infection. However, the underlying mechanisms responsible for this complication remain unclear. A better understanding of causative processes by which COVID-19 may lead to cognitive impairment is...
alzres.biomedcentral.com
I am also hearing reports that SARS-CoV-2 directly attacks the islets of Langerhans in the pancreas, and may cause new-onset diabetes.
SARS-CoV-2 is shown to infect and replicate in human pancreatic tissue, including in β-cells, which is associated with morphological, transcriptomic and functional changes.
www.nature.com
This is in addition to the SARS-like sequelae of lung fibrosis, lipid metabolism shifts, and post-viral fatigue that it apparently causes.
My only intentions in all of this were to unravel the pathology of COVID-19, to better understand what the hell we were facing, and to help people take precautions to protect their lives and their health from this virus. I am not here to gloat, or to say that I was right. I would’ve been much happier being wrong. The idea that an airborne, highly transmissible virus could cause permanent damage along these lines is very disturbing. However, this is what I’m seeing in published papers and articles in JAMA, Lancet, Elsevier, Nature, Wolters Kluwer, Springer, et cetera. If nothing else, this is what scientists currently believe to be true about COVID-19. Are all these scientists compromised? Are they all accepting bribes or malign influence? Surely, some of them believe what they’re publishing about the virus is true.
I do know one thing. Anthony Fauci, Ralph Baric, Shi Zhengli, and Peter Daszak are all criminals. This thing came out of a lab, with grant money funneled by the NIH, DOD, and USAID to China through Peter Daszak’s NGO which was used to conduct gain-of-function research. It was outsourced because it was under a federal funding moratorium due to the danger of a lab escape, and they wanted to continue the research in defiance of that order.
British scientist Peter Daszak's organisation channelled cash to Wuhan scientists to do the Gain-of-Threat experiments that caused the Covid-19 Pandemic.
www.peterdaszak.com
British scientist Peter Daszak's organisation channelled cash to Wuhan scientists to do the Gain-of-Threat experiments that caused the Covid-19 Pandemic.
web.archive.org
World leaders worked with the virus, not against it, by suppressing cures that could have prevented a large number of excess deaths.
Many of humanities leading voices in the fields of science, healthcare, law and journalism are speaking out. I invite you to listen to these heroes of humanity, who risk everything to inform you about what is truly happening in the world today.
www.stopworldcontrol.com
COVID-19 early treatment: real-time analysis of 1,475 studies
c19early.com
July 9, 2021 ... not novel... no pandemic.. no variants... campaign of coercion & terror to address a stated objective. Dr David Martin, SG!! Who can tell us what the Vaxxed can do about this synthe...
odysee.com
So much has happened over the past year that it may be hard to remember what life was like pre-COVID. But let’s flash back to December 2019, when the idea of social distancing, compulsory masking and lockdowns would have been met with disbelief and outrage by most Americans.
www.organicconsumers.org
(Great Game India) – A confidentiality agreement shows potential coronavirus vaccine candidates were transferred from Moderna to the University of North Carolina in 2019, nineteen days prior to the official emergence of Covid-19 pandemic. The confidentially agreement (read below) states that...
truthunmuted.org
A confidentiality agreement shows potential coronavirus vaccine candidates were transferred from Moderna to the University of North Carolina in 2019, nineteen days prior to the official emergence of Covid-19 pandemic.
greatgameindia.com
There is a paper trail. Every aspect of both the virus and the vaccine were patented. They created the disease, and then, they sold the cure for billions of dollars. A ”cure“ that may be worse than the actual disease by far.
Are you aware of Antibody Dependent Enhancement?
sciencewithdrdoug.com
This is fraud, racketeering, and mass murder, conducted with the assistance of social media, tech giants, and public officials who all worked to suppress the truth. This isn’t US versus China. That’s a cleverly-crafted illusion. The government is taking marching orders from the Illuminati, and the Illuminati want us all dead. No one else has the resources to pull it off. These motherfuckers have embezzled trillions of dollars. They can bribe and pressure anyone they like, even heads of state. Why do you think there is chaos in South Africa, right now? They were asking questions that the powers-that-be did not want to be asked.
The Committee of 300 shadow government banking nexus https://alcuinbramerton.blogspot.com/2016/05/the-white-spiritual-boy-off-ledger.html A...
alcuinbramerton.blogspot.com
They could have ended world hunger. They could have solved any scientific or technological problem imaginable. They could have built a paradise. Instead, they have unleashed hell. They have shown, on multiple occasions in the recent past, that they can start color revolutions wherever they like, using their sizable wealth to contract private intelligence firms who will, in turn, supply marching orders to compromised NGOs and flood social media with bots to try and manipulate people and cause unrest in targeted societies. Antifa/BLM in the US was no different from the Arab Spring, or the Euromaidan. All were manufactured color revolutions, completely inorganic and crafted by the Elites to accomplish specific objectives.
Now, they have also shown that they are willing to funnel money into shadowy laboratories and start plagues out of nothing, just to whip people into compliance.
These monsters must be exposed, or soon, all of our freedoms will be stripped from us.
