Wuhan Coronavirus: Megathread - Got too big

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According to the EU's equivalent of VAERS they've had nearly 22k fatal events reported after vaccination and a metric fuckton of adverse reactions. Whatever, as long as they keep lining up for their boosters every 5 months.
ruhroh.png
 
According to the EU's equivalent of VAERS they've had nearly 22k fatal events reported after vaccination and a metric fuckton of adverse reactions. Whatever, as long as they keep lining up for their boosters every 5 months.
View attachment 2489144
So COVID-19 has killed over 1 million in the EU/UK since 2020. The vaccine has already killed 22k in the span of, what, six months in 2021?

It's hard to get an accurate COVID-19 seasonal number, because they don't count the deaths seasonally, unlike the flu.

If I do some lazy math, let's say 600k people in the EU died of COVID-19 since the vaccine came out in 2021.
Then, this is what percentage of vaccine casualties that equates to:
1630188935027.png

You have a 99.9% chance of surviving COVID-19 infection (unless you're obese), but the vaccine has a 3% death rate compared to the general population. What the fuck?
 
Antigenic sin will likely make boosters useless bc they won't be able to overwrite existing immune memory (like they can't do it right now in previously infected individuals). Several consecutive booster shots may do the trick, but no one really knows.
Natural infection will eventually overwrite immune memory, but in the best case it will lead to delayed immune response (and suppressed innate antibodies, probably), and in the worst case it'll cause ADE.
As for longevity of immunity, people had their anti-SARS-1 and MERS antibodies recalled by SARS-2 infection. That's 20 and 8 years, respectively.
Vaccine manufacturers most likely know about antigenic sin, but they'll keep their mouths shut and try to sell as many vaccines as they can and politicians/public health officials are too incompetent and/or entangled in bureaucracy to change course.

His party's ratings are Ridin' with Biden, thus virtue signaling. Will be reversed/forgotten after Sept, 19.
The vaccines increase the risk of ADE, you prevent it by taking the booster to protect against symptoms when the vaccine wears off, the booster increases the risk of ADE, you prevent it by taking the booster to protect against symptoms when the vaccine wears off, the booster increases the risk of ADE, you prevent it by taking the booster to protect against symptoms when the vaccine wears off, the booster increases the risk of ADE, you prevent it by taking the booster to protect against symptoms when the vaccine wears off, the booster increases the risk of ADE, etc.

That's how you create lifetime customers of your drug company out of healthy people, like the transsexual lobby.

The phenomenon you're describing is antibody-dependent enhancement (ADE). More specifically, it is vaccine associated disease enhancement (VADE).

(Which I'm explaining because I had to look it up - so I'm assuming others don't know about it either.)

Wikipedia says that this prevented other vaccine candidates (for RSV, Dengue virus and other coronaviruses – including the O.G. SARS virus) from getting to market. It has also been observed in animal studies for COVID-19, but not in human immunisations (...so far??).

This looks reassuring on the surface..... but it doesn't exactly inspire me with confidence, especially when the same article links to a list of COVID-19 misinformation, which reads like a NPC bible of "tRuSt tHe sCiEnCe" talking points.

I was able to do a few more searches once I was armed with the above two terms. So far I haven't found anything conclusive - I'll say that now.

There's this Nature paper from almost a year ago, the conclusion of which says ADE in COVID-19 vaccinations is unknown, but unlikely.

Screen Shot 2021-08-28 at 22.03.31.png


We also have this study about whether the risk of ADE was communicated adequately to trial subjects (they say it wasn't) - which mentions in passing the "strong evidence that ADE is a non-theoretical and compelling risk for COVID-19 vaccines".

Published a month or so after the first. :-/

There may be more. I'm not very good at searching for science stuff.

The first article was tweeted out recently by Robert Malone (the mRNA vaccine developer who has spoken out against their use), who by the way has appeared in an interview in which he claims the (((Israeli database))) shows emerging evidence of this.


(Not sure when the clip is from, but it appears to be the last 2 months.)

Anyway, I'm sorry this post has been such a stream of consciousness. I just haven't drawn any meaningful conclusions about ADE/VADE yet.... not that I don't love and trust my fellow Farmers. But I literally haven't heard anyone else talk about this until now (not even ROTC or No Agenda, and I listen to those a lot).

But I know what my gut says, and it's that the mainstream news is lying to me, again.


Finally, if you'll allow me to be autistic about this for a moment, I just really, really... really fucking HATE that I feel the need to do my own research about a thing like this. Because that's what the news should be for. I used to be able to trust authoritative news sources to get the facts right when it mattered, but in the last few years they have broken my trust so badly that I cannot. I just cannot. But I can't believe the first person who says the exact opposite. So I have to spend time and effort coming to my own conclusions.

Not because I claim to know anything about immunology, but because assholes on the internet keep pointing out the obvious contradictions in official stories, undeclared biases, and even outright lies.

When I'd sooner trust a guy who identifies as a rifle on Kiwi Farms than the vast majority of professional science communicators, that should say something about the state of the world.

And all that Wikipedia ever seems to want to do is repeat the half-truth assertions of the so-called "experts" and dismiss legitimate concerns as they it were mere """misinformation"". Name a mainstream news outlet, and chances are that they're doing it too. This sucks. Clownworld fucking sucks!!

Maybe the authoritative news sources were never as authoritative as my past self used to think they are, and the scales have only fallen from my eyes in the last year or two as the result of personal circumstances. That's always a possibility. So yeah, SERIOUS QUESTION: was mainstream news always this bad and people like me have only just noticed?

I just really fucking resent that journalists and Wikipedians (AKA volunteer journalists) have been making me feel this paranoid as of late and causing me waste so much valuable time and effort that could have been spent on something – ANYTHING more productive than this. I also can't see there being any way around it, unless I find a way to become as brainwashed and docile as most other people that I know. Maybe that's what I've been missing in life – the ability to trust and be moulded. Maybe we'd all just be happier if we finally stopped worrying and learned to love the quarterly Fauci-Ouchie!!!
 
So COVID-19 has killed over 1 million in the EU/UK since 2020. The vaccine has already killed 22k in the span of, what, six months in 2021?

It's hard to get an accurate COVID-19 seasonal number, because the don't count the deaths seasonally unlike the flu.

If I do some lazy math can say 600k people in the EU died of COVID-19 since the vaccine came out, this is what percentage of vaccine casualties that equates to:
View attachment 2489161
Nope, both of those numbers are wrong. The 22k is suspected reported fatal events, nobody knows the real number it's probably half that or less. It's not easy to say that someone dies *from* the vaccine, usually they die from a complication that may or may not be directly related. Watching the VAERS or EU equiv reported numbers is more useful to look for trends. Which are way up. But using the numbers like you are trying to do is not appropriate because the margin of error is so huge.

The other number, the total deaths are also "with covid" not death "from covid". An important distinction.

Thank you for attending my ted talk on the importance of understanding numbahs.
 
Nope, both of those numbers are wrong. The 22k is suspected reported fatal events, nobody knows the real number it's probably half that or less. It's not easy to say that someone dies *from* the vaccine, usually they die from a complication that may or may not be directly related. Watching the VAERS or EU equiv reported numbers is more useful to look for trends. Which are way up. But using the numbers like you are trying to do is not appropriate because the margin of error is so huge.

The other number, the total deaths are also "with covid" not death "from covid". An important distinction.

Thank you for attending my ted talk on the importance of understanding numbahs.
It's honestly difficult to make any estimate since they over inflate COVID-19 with deaths that were not directly caused by COVID, and the medical community is seemingly vehemently against tracking vaccine side-effects properly. If someone is suspected to have died from vax side effects, there is a religious fervor to shut the idea down.

I don't know how closely vaccine deaths are even being tracked, but believe it's under-counted. Especially since the long-term studies are still going on, and no one who got the shot is actually directly reporting their side effects to the pharmaceutical companies.
 
Cuntface here has decided that only the special citizens get their freedoms. Thankfully there are a few people I know worried about this mostly because they're pro 'defund the police' but hey ill take it.




"More freedoms"...That is a dangerous thing to hear from your government. If that doesnt frighten you deeply, then you havent really been paying attention to history. There hasnt come a single good thing after the government begins to turn freedoms into previleges and not god given birth rights....

Honestly, I wonder how can this password crap be properly added. It feels like this is something that works more in theory as Im sure people will find easy ways around it. Besides, how long we can ignore how, and excuse me for daring to suggest this, nazi germany ish it all sounds some government thug entering your establishment and then begin harassing the clients with "papers, please!". Its difficult to not look at this and immediately think of those wacky germans...

I love how they fuck up the economy so business owners are going to be more inclined to obey so their businesses arent finantially fucked with a fine, when not outright closed.

This isnt freedom, this isnt democracy, this is TYRANNY
Now, I'd be inclined to agree with the sentiment of the last sentence, vaccinations are generally better than catching a disease since you can get immunity without having to deal with the actual sickness. Lord knows how many lives have been saved over the years due to proper and effective vaccines.

But when it's clear that these shots do not provide any immunity whatsoever, and may in fact be wrecking immunity and causing worse illness down the line? Then it's absolutely fucking retarded to continue to support them.
What I miss about the swine and bird flus is no "Narrative" shoved on the "little people", with any evidence to the contrary being "called out" as "misinformation", "anti-science", or "conspiracy theory". They weren't really politicized or used to grab power. Even the ebola scare didn't have "New Normal" crap.

Its their response to resistance that is extremely telling. We had so many viruses in the past but we have never reached this level of wanting to fuck with the general public...

Either the government has grown too bold for their own good or they are following their own agendas (maybe both)
I really think that the most rational explanation of introducing this level of tyranny at this point of history is the fact that all the Western economies are broke beyond any recovery. They are trying to limit our freedoms, and possibly cull the population, and they might even think of themselves as humanitarian, if they think this way they avoid mass starvation and social unrest.

The economy was doing fine under Trump tho...it actually FELT we were on the way to some level of recovery until 2020...
 
You know people hate baby boomers, but really we should hate The Silent Generation, for the shape of the current era. Here are 4chan threads about it.

/pol/ - Oldfag here. I can explain everything vax you are seeing - Politically Incorrect - 4chan

Oldfag here. I can explain everything vax you are seeing - "/pol/ - Politically Incorrect" is 4chan's board for discussing and debating politics and current events.

/pol/ - New thread cont from >>336562439 - Politically Incorrect - 4chan

New thread cont from >>336562439 - "/pol/ - Politically Incorrect" is 4chan's board for discussing and debating politics and current events.

So this goes to show that the greatest generation was the last fully great generation.
 
You know people hate baby boomers, but really we should hate The Silent Generation, for the shape of the current era. Here are 4chan threads about it.

/pol/ - Oldfag here. I can explain everything vax you are seeing - Politically Incorrect - 4chan

Oldfag here. I can explain everything vax you are seeing - "/pol/ - Politically Incorrect" is 4chan's board for discussing and debating politics and current events.

/pol/ - New thread cont from >>336562439 - Politically Incorrect - 4chan

New thread cont from >>336562439 - "/pol/ - Politically Incorrect" is 4chan's board for discussing and debating politics and current events.

So this goes to show that the greatest generation was the last fully great generation.
Archived
 
So COVID-19 has killed over 1 million in the EU/UK since 2020. The vaccine has already killed 22k in the span of, what, six months in 2021?

It's hard to get an accurate COVID-19 seasonal number, because they don't count the deaths seasonally, unlike the flu.

If I do some lazy math, let's say 600k people in the EU died of COVID-19 since the vaccine came out in 2021.
Then, this is what percentage of vaccine casualties that equates to:
View attachment 2489161
You have a 99.9% chance of surviving COVID-19 infection (unless you're obese), but the vaccine has a 3% death rate compared to the general population. What the fuck?
Yeah, it means its working.
(3% the first 8 months, hold my beer)
 
The economy was doing fine under Trump tho...it actually FELT we were on the way to some level of recovery until 2020...
That could be why there's "New Normal": power grab, Orange Man bad, centralize economy under globalism.

Now it's back to the endless recession from 2008 that never really ended (aside from a break under Trump)?
 
When I'd sooner trust a guy who identifies as a rifle on Kiwi Farms than the vast majority of professional science communicators, that should say something about the state of the world.
It's worse, since you end up trusting a paranoid nutjob who claims to be a "sailor" (he pumps the oil on a ferry) and wants to be a My Little Pony and get fucked up the ass by futa My Little Ponies.

But somehow this guy ends up furthering the cause of science education because he dumps the sources right there and drops a summary. Think how sad it is that veteran, professional science educators like Bill Nye and their ilk get BTFO by a fat guy on the internet who wants to be a My Little Pony.
 
Because you fuckers don't understand math.

I don't want to get Covid to avoid getting Covid, you idiot. You are right it is far better to have had coivd to fight off Covid, but i will take the less then 1.5% chance of getting Covid with the vaccine over having to get fucking covid.
1.5% chance of catching Covid compared to someone who's never had the jab which is....

I don't think it's the answer you'll be expecting.

Unvaccinated people ARE probably still more likely to catch Covid, and when we do it means we are properly immune. For the non-jabbed Covid is presenting a smaller and smaller target as more of us contract the coof. For us Covid will soon be a distant memory of being sick that one time. The vaccinated OTOH will exist in a limbo of constant re-infections due to their fucked up immune systems, desperately waiting on their next booster praying to God that the next time they develop a cough it won't be the ADE version.

In our study, we show that following vaccination, the levels of anti-SARS-CoV-2 antibodies decrease rapidly, indicating that BMPCs may not be created adequately and therefore anti-SARS-CoV-2 humoral immunity might be transient (Ibarrondo et al., 2020; Seow et al., 2020).

This is from the study you read in great detail, I'm sure then you already know what it means. The vaccines are inducing no B-cell recall which means no immunity once the neutralising antibodies are gone, none. The antibodies that are induced quickly dissipate on an exponential curve at the rate of 40% per month. You know how Fauci came up with the 8 months for the booster? Because he's read this study and virtually none of the vaccinated will have any neutralising protection against the coof after this time.
 
The phenomenon you're describing is antibody-dependent enhancement (ADE). More specifically, it is vaccine associated disease enhancement (VADE).

(Which I'm explaining because I had to look it up - so I'm assuming others don't know about it either.)

Wikipedia says that this prevented other vaccine candidates (for RSV, Dengue virus and other coronaviruses – including the O.G. SARS virus) from getting to market. It has also been observed in animal studies for COVID-19, but not in human immunisations (...so far??).

This looks reassuring on the surface..... but it doesn't exactly inspire me with confidence, especially when the same article links to a list of COVID-19 misinformation, which reads like a NPC bible of "tRuSt tHe sCiEnCe" talking points.

I was able to do a few more searches once I was armed with the above two terms. So far I haven't found anything conclusive - I'll say that now.

There's this Nature paper from almost a year ago, the conclusion of which says ADE in COVID-19 vaccinations is unknown, but unlikely.

View attachment 2488967

We also have this study about whether the risk of ADE was communicated adequately to trial subjects (they say it wasn't) - which mentions in passing the "strong evidence that ADE is a non-theoretical and compelling risk for COVID-19 vaccines".

Published a month or so after the first. :-/

There may be more. I'm not very good at searching for science stuff.

The first article was tweeted out recently by Robert Malone (the mRNA vaccine developer who has spoken out against their use), who by the way has appeared in an interview in which he claims the (((Israeli database))) shows emerging evidence of this.

View attachment 2489011
(Not sure when the clip is from, but it appears to be the last 2 months.)

Anyway, I'm sorry this post has been such a stream of consciousness. I just haven't drawn any meaningful conclusions about ADE/VADE yet.... not that I don't love and trust my fellow Farmers. But I literally haven't heard anyone else talk about this until now (not even ROTC or No Agenda, and I listen to those a lot).

But I know what my gut says, and it's that the mainstream news is lying to me, again.


Finally, if you'll allow me to be autistic about this for a moment, I just really, really... really fucking HATE that I feel the need to do my own research about a thing like this. Because that's what the news should be for. I used to be able to trust authoritative news sources to get the facts right when it mattered, but in the last few years they have broken my trust so badly that I cannot. I just cannot. But I can't believe the first person who says the exact opposite. So I have to spend time and effort coming to my own conclusions.

Not because I claim to know anything about immunology, but because assholes on the internet keep pointing out the obvious contradictions in official stories, undeclared biases, and even outright lies.

When I'd sooner trust a guy who identifies as a rifle on Kiwi Farms than the vast majority of professional science communicators, that should say something about the state of the world.

And all that Wikipedia ever seems to want to do is repeat the half-truth assertions of the so-called "experts" and dismiss legitimate concerns as they it were mere """misinformation"". Name a mainstream news outlet, and chances are that they're doing it too. This sucks. Clownworld fucking sucks!!

Maybe the authoritative news sources were never as authoritative as my past self used to think they are, and the scales have only fallen from my eyes in the last year or two as the result of personal circumstances. That's always a possibility. So yeah, SERIOUS QUESTION: was mainstream news always this bad and people like me have only just noticed?

I just really fucking resent that journalists and Wikipedians (AKA volunteer journalists) have been making me feel this paranoid as of late and causing me waste so much valuable time and effort that could have been spent on something – ANYTHING more productive than this. I also can't see there being any way around it, unless I find a way to become as brainwashed and docile as most other people that I know. Maybe that's what I've been missing in life – the ability to trust and be moulded. Maybe we'd all just be happier if we finally stopped worrying and learned to love the quarterly Fauci-Ouchie!!!

Nature paper archive.

ADE risk/informed consent archive.

Paper PDFs also attached.

EDIT: You may already be familiar with it, but a useful tool for hunting scientific/academic papers is the search engine Semantic Scholar.
 

Attachments

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You know people hate baby boomers, but really we should hate The Silent Generation, for the shape of the current era. Here are 4chan threads about it.

/pol/ - Oldfag here. I can explain everything vax you are seeing - Politically Incorrect - 4chan

Oldfag here. I can explain everything vax you are seeing - "/pol/ - Politically Incorrect" is 4chan's board for discussing and debating politics and current events.

/pol/ - New thread cont from >>336562439 - Politically Incorrect - 4chan

New thread cont from >>336562439 - "/pol/ - Politically Incorrect" is 4chan's board for discussing and debating politics and current events.

So this goes to show that the greatest generation was the last fully great generation.
Quoting for mobile friends:
In 1969-1972, a creepy Christian cult phase swept America. Silent Gen were the cults' leaders. Fauci, his wife, and most pharma/MSM/politicians today in the US are Silent Gen. Here's facts you need to know:
When you see people start covering their cars with political stickers, whatever side they belong to is the Gullibles. These people trust "leaders", join cults, and will be violent against and kill whoever the cult says are the enemy. 20 years ago this was our side. Now it's the left. Who do you see sticking stickers all over their cars today? Left or right?

In 1969-1972, our Gullibles got very into cults which sprang up everywhere. Mormonism also increased during this era. Every week, almost every night, the news announced that some cult leader and his wife, and their powerful upper team members, had induced the cult's sheep to ingest this or that substance, to do this or that other suicidal thing, and perform a mass die-off. You young have no idea how widespread this phenomenon was and how common it became. Literally every week a new cult, usually starting in Texas, Utah or California with a leader from the Midwest (think Manson and Ohio), ended violently with heaps of bodies discovered dead in remote places because their cult leader simply just fucking wanted lots of dead, and told them to ingest, drink or inject whatever substance. There was no logical reason. The leader just LIKED DEATH.

You are all trying to find and assign another reason. That's where you're wrong. It's illogical. There IS no other reason.

Fauci and his band simply LIKE DEATH.

In every last single case of these instances the cult leader was Silent Generation. These people are born authoritarians. They are also Gen X's parents. This is why we know them and their tactics extremely well, we were raised and cult hazed by them in the 60's-80's. Their favorite phrases: "My way or the highway." "Because The Bible/Jesus/Science says so." "Not in MY house it isn't." "Well, in THIS house, we..." "You will do as I say or be destroyed." "Anyone who disagrees with what I have just instructed you is evil/the enemy/out to kill you, trust only me."

Sound familiar? Now let's examine some dates. Silent Generation's birth period was generally 1925-1943. Examine these birthdates.

Charles Manson
November 12, 1934

Anthony Fauci
December 24, 1940

Klaus Schwab
March 30, 1938

Nancy Pelosi
March 26, 1940

Joseph Robinette Biden
November 20, 1942

I could add lots more names but our entire political system, both parties, our media and almost all major US corporations right now are headed by members of Silent Generation.

EVERYONE CURRENTLY IN REAL POWER WAS BORN IN THIS PERIOD. NO EXCEPTIONS.

This is a group very prone to authoritarian, jack booted tendencies. They all consider themselves teachers and religious leaders with "something important to say to younger people". This is part of why all their songs in the Sixties expressed that and why during same decade and the Seventies many of them became religious figures, traveled to and from India hanging out with "gurus" and came back launching little cults of their own. If Fauci were not in a blue scrub, a suit, or a white lab coat HE ABSOLUTELY WOULD BE IN RELIGIOUS ROBES LIKE KLAUS SCHWAB ANNOUNCING EDICTS EXACTLY AS INSANE AND CONTROLLING FROM BEHIND A CHURCH PODIUM. Same sickness. Same Silent Gen lust for power. Same "I am a religious leader" air to him. Think about this.

As people grow old they become more obsessed with medicine. They hope to beat or cheat death and live forever. Baby Boomers share this same tendency. What we are being forced to live through is two ageing demographics who by rights should all be in cemeteries, living too long because Big Pharma, and who because of this worship Big Pharma, anxiously ruining everything in our younger lives out of their own lust for power. Notice how everything around this vaccine and virus now bears a certain religious tone to it, a sense of cult. This brings me to my central statement.

The 1970's began with cults and it ended with cults. 1969: Manson/Spahn Ranch. 1979: Jonestown.

You are being forced at near gunpoint to participate in an obscene worldwide death cult run by Silent Generation and its giddy Baby Boomer acolytes, and what you are seeing this morning is you, inside a Mormon-style church temple, backing towards the locked doors as the shiny-eyed devotees close in all around you with needles demanding to know why you refused to inject the Koolaid like Rev. Jim Fauci Jones instructed you.

Don't you want to be saved, anon?
Don't you want to see heaven?

It's 1969-1972 all over again, same generation behind it because they're on edge of death and senile thus obsessed with germs, fear, and mortality, and because they are in power and have been since 1950 and refuse to let go. Silent Gen are THE ENEMY, /POL/. I'm a Generation X-er and saw it and I was there. These bastards are our parents.

How long will we all let a bunch of totalitarian olds wreck our future to expand their cult? That's the question.

THEY ARE SENILE.
THEY HAVE GONE MAD.
IF YOU ACCEPT THE INJECTION YOU WILL LIKELY DIE. The cleanup from this will be fucking incredible.

It's JONESTOWN, INCORPORATED you are all witnessing happening.

Thanks for reading
 
@DoubleD "trust but verify" is one of the methods to avoid madness and sliding into total paranoia. Media is shite these days, due to a plethora of reasons, but you can still be able to find info if you're willing to sift through a pile of muck. Check out any library website- preferably academic- for the guides on how to search and recommended resources (journals, databases). A lot of them will be available on the open access basis or through other means.
 
According to the EU's equivalent of VAERS they've had nearly 22k fatal events reported after vaccination and a metric fuckton of adverse reactions. Whatever, as long as they keep lining up for their boosters every 5 months.
View attachment 2489144
please try to always indicate source, it's incredibly frustrating sifting through google results with all the fact-checking bullshit going on, save your kiwi frens the time and pain.

who put together this table? the officials would never give antivaxer this slam dunk using the word "experimental" anywhere in their documents.

only link I could find is a website called covid-crime.org
which references some random statista numbers to fish for legitimacy

if you look up the 4 vaccines https://www.adrreports.eu/en/search_subst.html# the total official number is 875k adverse cases, but number of deaths is not reported.
so to have death number you have to individually take each country report and put them together, thats a lot of work to do.
italy has around 10-15% of adverse cases reported in eu and as of july they report 498 deaths, so youd expect eu official total to be somewhere around 4000-5000 deaths.
(page 12)

I hate to be the asshole that pisses on people's parades but at this point I dont take anything at face value from either camp. also, checking the legitimacy of every new piece of info fucking sucks.
as a rule of thumb I'd avoid grainy, zoomed in, evidently photoshopped images with no links, I hold kikifarms to a much higher journalistic standard than this! :semperfidelis:

edit: corrected numbers.
 
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There actually does appear to be a silver bullet for COVID-19 hyperinflammation. An antidepressant called Fluvoxamine.


As 60 Minutes tells it, the first COVID-19–related fluvoxamine study began because Angela Reiersen, MD, MPE, was reflecting on potentially relevant medical studies when she herself was sick with COVID in March 2020. There was one that caught her attention: A 2019 Science Translational Medicine study that suggested fluvoxamine lowered inflammatory cytokine production and treated sepsis in mice.

"Mechanistically, we find that S1R [ER-resident protein sigma-1 receptor] restricts the endonuclease activity of the ER [endoplasmic reticulum] stress sensor IRE1 and cytokine expression but does not inhibit the classical inflammatory signaling pathways," write the researchers. "These findings could have substantial clinical implications, as we further find that fluvoxamine, an antidepressant therapeutic with high affinity for S1R, protects mice from lethal septic shock and dampens the inflammatory response in human blood leukocytes."

The same cytokine storm that is mentioned in this study is also an inflammation-causing symptom in COVID-19.

So, Reiersen mentioned it to her acquaintance Eric Lenze, MD, who became the lead author on a preliminary randomized clinical trial published in JAMA in November 2020, with Reiersen as senior author.

In that study, 80 participants with COVID-19 received 100 milligrams (mg) of fluvoxamine three times daily for 15 days, and 72 COVID-19 patients received a placebo. While 8.7% of the placebo group had to be hospitalized within 14 days because of worsening symptoms, none in the intervention group were.

Fluvoxamine isn't just an SSRI. It is also an antioxidant and inhibits endoplasmic reticulum stress, both of which are relevant to COVID-19.


Multi-system involvement and rapid clinical deterioration are hallmarks of coronavirus disease 2019 (COVID-19) related mortality. The unique clinical phenomena in severe COVID-19 can be perplexing, and they include disproportionately severe hypoxemia relative to lung alveolar-parenchymal pathology and rapid clinical deterioration, with poor response to O2 supplementation, despite preserved lung mechanics. Factors such as microvascular injury, thromboembolism, pulmonary hypertension, and alteration in hemoglobin structure and function could play important roles. Overwhelming immune response associated with “cytokine storms” could activate reactive oxygen species (ROS), which may result in consumption of nitric oxide (NO), a critical vasodilation regulator. In other inflammatory infections, activated neutrophils are known to release myeloperoxidase (MPO) in a natural immune response, which contributes to production of hypochlorous acid (HOCl). However, during overwhelming inflammation, HOCl competes with O2 at heme binding sites, decreasing O2 saturation. Moreover, HOCl contributes to several oxidative reactions, including hemoglobin-heme iron oxidation, heme destruction, and subsequent release of free iron, which mediates toxic tissue injury through additional generation of ROS and NO consumption. Connecting these reactions in a multi-hit model can explain generalized tissue damage, vasoconstriction, severe hypoxia, and precipitous clinical deterioration in critically ill COVID-19 patients. Understanding these mechanisms is critical to develop therapeutic strategies to combat COVID-19.


Viral glycoproteins are the main triggers of ER stress in the cell and bring about unfolded protein accumulation in the ER lumen, activating the UPR signaling pathway [10]. With the activated UPR pathway, the synthesis of GRP78 and other chaperone proteins increases, and protein kinase R-like ER kinase (PERK) protein and eIF2αSer51 protein are activated by autophosphorylation [11]. Subsequently, inflammation and apoptosis pathways are stimulated [12].

GRP78 protein is known to be involved in the intrusion of numerous viruses, such as Bat Coronavirus, Ebola Virus, MERS-CoV, Dengue Virus, Japanese Encephalitis Virus, Influenza Virus, and Zika Virus, into the host cell [13]. Previous research has demonstrated that MERS-CoV virus binds to GRP78 protein as well as dipeptidyl peptidase 4 (DPP4) protein for internalization to the host cell [13]. The fact that GRP78 protein expression is increased in SARS-CoV infection has also been documented in earlier studies [14].

The association between the SARS-CoV-2 virus and the GRP78 protein has been investigated in several studies, and the utility of this association has been proposed as a potential therapeutic target [[15], [16], [17]]. As molecular docking prediction studies reveal, if the virus is to enter the target cell expressing cell-surface GRP78, binding seems more convenient between Region IV of the SARS-CoV-2 spike protein and the GRP78 substrate binding domain (SBD). In our previous works, we reported that a marked increase emerges in serum GRP78 level in SARS-CoV-2 pneumonia, and that serum GRP78 mRNA levels rise substantially in Covid-19 pneumonia [16,17].


We recently demonstrated that endoplasmic reticulum (ER) stress induces sigma-1 receptor (Sig-1R) expression through the PERK pathway, which is one of the cell’s responses to ER stress. In addition, it has been demonstrated that induction of Sig-1R can repress cell death signaling. Fluvoxamine (Flv) is a selective serotonin reuptake inhibitor (SSRI) with a high affinity for Sig-1R. In the present study, we show that treatment of neuroblastoma cells with Flv induces Sig-1R expression by increasing ATF4 translation directly, through its own activation, without involvement of the PERK pathway. The Flv-mediated induction of Sig-1R prevents neuronal cell death resulting from ER stress. Moreover, Flv-induced ER stress resistance reduces the infarct area in mice after focal cerebral ischemia. Thus, Flv, which is used frequently in clinical practice, can alleviate ER stress. This suggests that Flv could be a feasible therapy for cerebral diseases caused by ER stress.


The 25, 50, 100 and 200 mg/kg doses of fluvoxamine exerted antiulcer effects of 48.5, 67.5, 82.1 and 96.1%, respectively, compared to the control rat group. Ranitidine showed an 86.5% antiulcer effect. No differences were observed in the absence of indomethacin treatment for any dose of fluvoxamine or for ranitidine. The levels of antioxidant parameters, total glutathione and nitric oxide, were increased in all fluvoxamine groups and in the ranitidine group when compared with the indomethacin-only group. In addition, fluvoxamine and ranitidine decreased the levels of the oxidant parameters, myeloperoxidase and malondialdeyhyde, in the stomach tissues of the rats when compared to indomethacin group.

All of the damage of COVID-19 hyperinflammation is caused by over-active neutrophils, monocyte-derived alveolar macrophages, et cetera. It's the patient's own immune system that's killing them. This is why it's absolutely ridiculous that they're dosing people in critical care units with antivirals, and then claiming that antivirals do not work. By that point, it's too fucking late for antivirals. The only things that work are immunomodulatory treatments to quell the sepsis.
 
Only women can become pregnant. Even If you were to surgically attach a fetus and placenta to a male body, the male would wont be able to support the growth of the fetus due to lack of hormone necessary for gestation. Do you trust 'doctors' that don't even know this? Do you trust them to know if a vaccine is safe?


<https://www.cdc.gov/coronavirus/2019-ncov/vaccines/recommendations/pregnancy.html>


COVID-19 Vaccines While Pregnant or Breastfeeding​

Updated Aug. 11, 2021
What You Need to Know

  • COVID-19 vaccination is recommended for all people 12 years and older, including people who are pregnant, breastfeeding, trying to get pregnant now, or might become pregnant in the future.
  • Evidence about the safety and effectiveness of COVID-19 vaccination during pregnancy has been growing. These data suggest that the benefits of receiving a COVID-19 vaccine outweigh any known or potential risks of vaccination during pregnancy.
  • There is currently no evidence that any vaccines, including COVID-19 vaccines, cause fertility problems in women or men.
  • Pregnant and recently pregnant people are more likely to get severely ill with COVID-19 compared with non-pregnant people.
  • Getting a COVID-19 vaccine can protect you from severe illness from COVID-19.

Saying 'pregnant people' is super retarded.

Maybe this should go is some Woke or Covid MegaThread, but it's worth posting all the same.
 
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