If this mod has Enclave, this is instant fail. The main saving grace of New Vegas (at least, for me) is that it didn't cling to the old material too much. Yeah, we have NCR, that was barely established in part 2, Khans, Brotherhood of Steel, but they all are moving forward, it's not just copypaste, like in Fallout 3, where they basically did "eh, who were the bad guys? Enclave? Let's bring them back. Who were the "good" guys? BoS? Let's make them only real good faction". And God was it dumb, when they dug up Enclave's corpse and made them even blunder.
Also, Enclave are kinda nazis. Their doctrine is "everything that has mutations should die, even if it looks like human and has healthy offspring".