In terms of just the 60s/70s goofy cartoon animals that talk shows... then not really since like others have said, they were products of their time, with the only ones to have long lasting endurance and continuous appeal even years later being the Flintstones, Wacky Races, Top Cat and Scooby Doo. Scooby Doo was always popular but I always found it pretty damn boring (same for its many clones). Jabberjaw is really corny but I liked it as a little kid on CN more than the other goofy toons/scooby clones, so it did its job well for the target demographic.
Personally, 60s/70s HB shined most in its action department, like Jonny Quest, Space Ghost, Sealab and whatnot. The 80s era was a huge step up for HB overall.
Top Cat's popularity stems a lot from the fact that his show revolved around the fact that he was a likeable conman and crook trying to fleece others and outwitting the cops but while always maintaining an air of likeability. I've heard kids in spanish-speaking countries also found him endearing because he lived in a trash can, much like that Chavo character from Mexican telly.