Riding the meme train is a strategy that objectively works. The guy who drew the original comic where the "total happiness in the world increased" meme spawned from ignored the inevitable politicized versions of it (whether or not he was against their views) and went along with it. Even people who disliked his comic commended him for owning up to it. Now his comic has spiked a little baby spike in popularity, according to Google Trends at least, and the comic itself at least has some marginal amount of relevancy compared to the meme it spawned.
Conversely you could take the Sarah Anderson approach, whose webcomic was hijacked and politicized to hell and back, and you can just throw a huge temper tanty about it just as Matt Furie did. Whoops, now you draw attention to yourself, people dislike you, the edits of your webcomic increase in frequency and are more popular than the webcomic itself, yet your dedicated supporting fanbase remains unchanged or even shrinks because of it.
Oh, and have something special from me:
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