I'm sorry but does that affect you in employment/social life? Or is it one of those things that you don't tell employers? I don't qualify right now (no diagnosis) but I did when I was younger. I remember seeing the absolutely disgust and contempt of the adults me around thinly veiled as help, or teachers deliberately giving me a hard time and my peers being judgemental (not that I cared about the latter) because my disability wasn't "visible" that left me with lifelong hatred of the public sector (esp education) that isn't volunteer because of this and I refuse to state that I have had or have (If I get disability) because of this. Just curious if anyone else has had this issue in life.
It affects me pretty much completely. I don't have friends IRL anymore since hs and I feel you wrt to public education. I got treated like shit for having NVLD which is like a girlier form of autism. I needed an IEP to pass my required science and math courses bc I struggle badly with those subjects. They never gave me an IEP bc "I'm too smart and not applying myself". I just kept failing and then my fatigue started so I dropped out of hs.
I've never worked except before I got sick in retail but my manager was a bitch so I told her to fuck off and kicked over a lighter display. I was 15 or 16. Also babysat a lot and didn't have a problem with it.
It's really hard to get approved for disability. I tried and the caseworker said I'm too well spoken to have a disability, so I was on welfare for three yrs which was like 550 Canadian a month at that time. After a few yrs I tried again and got approved and have been on it ever since. They reassess every yr to see if you still need it. They send a caseworker to your house to interview you. They didn't the last two yrs though bc of the panini.
How long do you think he can live with all the health things he's dealing with? I'm hoping at least 65. Is there anywhere in particular radiographs should be done to look for pso arth, what is the most likely place to find it? I did damage the ligaments in my foot falling down the stairs last yr and went to emerg and got a foot xray and they said it looked all good. Not sure if it was foot and ankle or just foot, but I hurt the top of my foot falling. It hurt so bad I thought it was broke, which is why I went to the hospital.
I will call the GP office Monday and ask for a referral to pulmonary for him. It was very rare he even agreed to go to the doctor while he was having that heart attack but I guess he felt so damn shitty he agreed and it's really lucky he did. I feel you on the negligent thing. There is a long waiting list in my province to get a GP so I can't switch her, but I do feel she undermines my concerns a lot. I'm actually on public disability for chronic fatigue. I just want answers you know? I agree prevention is much better than letting it cause damaging and then finally treating it.
It's very hard to say. If everything is expertly managed and he is 100% compliant, years. If it is managed poorly and his compliance with treatment is poor, far less than that. The most common areas of degeneration for pso arthritis are the large joints, elbows/knees and wrists/ankles, as well as the spine, typically the cervical or lumbar regions.
I know there have been a couple of diagnostics they have come up with recently for CFS in the last few years. A colleague of mine was involved with it at one of the research universities in Texas. I'll send him an e-mail and ask him for more information. It might give you something that you can ask after your GP for a more definitive diagnosis.
Thanks for the reply. I've been told that "You don't fit the standard presentation for anything so we must use an exclusionary diagnosis".
In re: MRI contraindication. I have several surgical implants that are full metal in the joints and they told me they will not do an MRI due to risk of it moving and tearing my axillary artery (how accurate this is, I do not know). I can feel the metal pulling if I walk close to large magnets like a cyclotron
In re chemical allergy:
I pretty sure I am allergic (swelling, contact dermatitis) with certain plastics with specific coloration . Specifically, I am allergic to the plastic of older hasbro board games. I got a friend to do a double blind with a set I haven't seen before and couldn't see while picking up and it was 100% the same symptoms every time I picked up gold/pink colored plastic. So I keep a pair of gloves when I have to pick up stuff like that now.
I took a look at the Acephalgic Migraine and it fits my symptoms pretty well. Usually induced by a atmospheric pressure drop/olfactory trigger. First come Neck stiffness, yawning with a sense of foreboding followed by blindness in one eye, vertigo, sensitivity, confusion, and jaw pain/ grinding on the same side as the eye (I don't have tetnus I'm 100% sure). The only thing that doesn't fit is an extreme shooting pain through the top/front of the head. My usual go to test is to try and walk up a set of stairs, if I fall or stumble I know I'm going to get a bad day.
Are cluster headaches possible at the same time? I had for the longest time severe cluster headaches misdiagnosed (?) as trigeminal neuralgia when I was a child. Went into remission after I got the hospital stay (see earlier post) from the infection but got replaced by this shit after my surgical implants (I was sedated for an extended period of time for both). Not sure if the fact I travel a lot with a 12 hour time difference for work/life since I was in my very young also affects this.
As far as the plastics. It is likely you have what is known as a "Type IV" hypersensitivity. The symptoms you mentioned are classic for it. It's strictly touch based. Its likely you are reacting to a particular additive in the plastic. If you go to an allergist/immunologist they might be able to tell you exactly which ones are you hypersensitive to with a multiple sensitivity test. Knowing exactly what you are hypersensitive to can help to avoid it since certain chemicals can show up in strange places/get transferred onto/into unusual things.
A history of cluster headaches is interesting, especially that young, and that it went away post resolution of the infection, but then this started. That does complicate the diagnosis a bit. It's possible what you are experiencing is a variant of a cluster headache now, an acephalgic type, being no pain associated with it. Cluster headaches can be associated with unilateral, focal cranial nerve palsy. I have never heard of cluster headaches and migraines occurring at the same time since their mechanisms of manifestation are usually quite different.
As far as the plastics. It is likely you have what is known as a "Type IV" hypersensitivity. The symptoms you mentioned are classic for it. It's strictly touch based. Its likely you are reacting to a particular additive in the plastic. If you go to an allergist/immunologist they might be able to tell you exactly which ones are you hypersensitive to with a multiple sensitivity test. Knowing exactly what you are hypersensitive to can help to avoid it since certain chemicals can show up in strange places/get transferred onto/into unusual things.
A history of cluster headaches is interesting, especially that young, and that it went away post resolution of the infection, but then this started. That does complicate the diagnosis a bit. It's possible what you are experiencing is a variant of a cluster headache now, an acephalgic type, being no pain associated with it. Cluster headaches can be associated with unilateral, focal cranial nerve palsy. I have never heard of cluster headaches and migraines occurring at the same time since their mechanisms of manifestation are usually quite different.
Again, thanks for replying. I wish I knew more but my job is mainly pulling people out of wrecks and fires and keeping them from dying.
For allergies, I have done allergy tests before. I have returned negative for everything except for some grass (minor, contact dermatitis) . I'll try to get my allergist to run a test with plastics, I know I did earlier but they refused because they weren't sure how to get the additives.
I don't understand your point on the acephalgic type cluster headache. I most obviously do get pain while it occurs.
Time for another neurologist I guess since this one keeps dismissing my issues.
For allergies, I have done allergy tests before. I have returned negative for everything except for some grass (minor, contact dermatitis) . I'll try to get my allergist to run a test with plastics, I know I did earlier but they refused because they weren't sure how to get the additives.
I have type 4 hypersensitive allergies and just wanted to say I feel your pain. I’m on immunosuppressants for one of them. Not going to go into details of stuff because even though it’s very interesting; I live in fear of ending up in the munchie thread.
I don't understand your point on the acephalgic type cluster headache. I most obviously do get pain while it occurs.
Time for another neurologist I guess since this one keeps dismissing my issues.
Okay, I don't trust anywhere else (ironic) with this because fucking doctors and the medical industry have screwed my family over more than once.
I have what seem to be seizures or TIAs randomly currently, but the neurologist blows it off since I'm "young and shouldn't have any issues". Basically, prolonged stress will cause me to loose control of my right eye, and I get disorientated with vertigo. Thankfully I know when I get these attacks since I have a gut feeling the day I wake up.
Now here's the kicker, I had a life threatening infection that had me hospitalized from a sinus that went into the brain when I was younger, but I don't have any lasting damage. Eye doctor said eye+nerve is physically "fine". Head and neck CT show fine except for minor chronic sinus blockage on right ethmoid and sphenoid sinus. Contraindicated for MRI.
Aside from another neurologist/ENT, what else should I see?
The cardiologist believes it to be a heart issue, and wants to do an invasive trach ultrasound to confirm the lack of a small hole in the right chamber causing clots to form. Any thoughts on if I'm being fleeced and bullshitted or actually possible? Prefer not to do it if possible.
Summary for me:
Age<30, no elevated blood tests, healthy BMI, asymptomatic hypo-tension (95/45) and normal heart rate. ECG and EKG normal.
Does anyone know how to deal with a severe chemical allergy? I cannot stand perfume or gas fumes since it causes an immediate headache and vertigo, but no anaphylaxis. This is why I don't have a social life because lol try explaining that one to women.
"Basically, prolonged stress will cause me to loose control of my right eye, and I get disorientated with vertigo. "
You did mentioned it regarding the potential chemical allergy, but not related to the onset of symptoms related to stress.
Pain changes things, if you have pain at the onset of the other symptoms, it's straight up cluster headaches. Cranial nerve dysfunction is not uncommon with cluster headaches.
I have type 4 hypersensitive allergies and just wanted to say I feel your pain. I’m on immunosuppressants for one of them. Not going to go into details of stuff because even though it’s very interesting; I live in fear of ending up in the munchie thread.
Actually, you didn't list pain as a symptom in your initial post on the subject:
"Basically, prolonged stress will cause me to loose control of my right eye, and I get disorientated with vertigo. "
You did mentioned it regarding the potential chemical allergy, but not related to the onset of symptoms related to stress.
Pain changes things, if you have pain at the onset of the other symptoms, it's straight up cluster headaches. Cranial nerve dysfunction is not uncommon with cluster headaches.
That part sucks. Check your salt, I know in China the yellow prussiate of soda is known to cause thyroid issues with women (I think because some of it is not natural salt and chemically made, dunno if that's an issue if you live not in China).
Any yeah, my allergies sucks because it's not obvious to most people. I can feel the reaction swelling but it usually isn't visible. The only time I wasn't 100% mocked was in chemistry class. I had a williamerson ether synthesis reaction of something and just passed out and got yelled at and almost failed the class. Fuck that course. Was funny how the TA and the teacher both got fired since the guy next to me accidentally lit his desk on fire with a mixture of limonene and DMSO a few classes later.
Check your salt, I know in China the yellow prussiate of soda is known to cause thyroid issues with women (I think because some of it is not natural salt and chemically made, dunno if that's an issue if you live not in China).
Thanks but I have hypoparathyroidism (no working parathyroid glands) as well as hypothyroidism (hypothyroidism is nothing compared, I had it before my thyroid got yeeted).
The short, layman version is it’s a bit like beetus but with calcium not glucose, mostly caused by surgery and much rarer than T1 beetus with no home tester. In my country it’s controlled(ish) by activated vitamin d analogs (normal vitamin d doesn’t work due to missing the hormone made by the paras) and calcium supplements. There is no replacement hormone available here.
Thanks but I have hypoparathyroidism (no working parathyroid glands) as well as hypothyroidism (hypothyroidism is nothing compared, I had it before my thyroid got yeeted).
The short, layman version is it’s a bit like beetus but with calcium not glucose, mostly caused by surgery and much rarer than T1 beetus with no home tester. In my country it’s controlled(ish) by activated vitamin d analogs (normal vitamin d doesn’t work due to missing the hormone made by the paras) and calcium supplements. There is no replacement hormone available here.
It's the same treatment in the US, Vitamin D analogs, Calcium, Magnesium, & Thiazide diuretics. There is a synthetic parathyroid hormone, but it is only used for people who have uncontrollable calcium levels with standard treatment. The reason is that it could potentially cause bone cancer. So, not a treatment I would try unless my life was at risk.
So I came back after some fun with the dildo session. Doctor said I looked fine but noticed I had some minor mital regurgitation not noticed on the normal ultrasound about 2 months ago. Not sure if I should be worried about that since rheumatic fever and mital heart issues run in one side of my family, any insight appreciated. Doctor just said to keep an eye on it and maybe get an ultrasound every 5-10 years.
For general dataset, male 18-35, 6ft, 135lbs.
Also my entire work department came down with COVID. Fun times for me. I got a 102 Fever but no positive result lol.
Vent. Rate : 058 BPM Atrial Rate : 058 BPM
P-R Int : 156 ms QRS Dur : 090 ms
QT Int : 436 ms P-R-T Axes : 014 080 052 degrees
QTc Int : 428 ms
Sinus bradycardia
Otherwise normal ECG
When compared with ECG of MARCH-22
No significant change was found
EF:normal
AoV:normal
MV:normal (mild myxomatous changes, trace MR)
TV:normal
PV:normal
Bubble study:negative for PFO
Vegetations:n/a
LAA: no clot
There's more than one orifice in a human dear. It was a very bad joke. After all it was a transesophageal ultrasound.
Yes. What's interesting though is one side of my family all gets it in their early-mid 20s-30s so long as we aren't living in tropical la la land like Florida (Pro-tip, I'm too poor/busy with business to live in FL).
Yes. What's interesting though is one side of my family all gets it in their early-mid 20s-30s so long as we aren't living in tropical la la land like Florida (Pro-tip, I'm too poor/busy with business to live in FL).
Do you have your CRP tested in your routine blood tests? You could have a tendency towards inflammatory states in your family. Autoimmune or otherwise. They can present as fevers sometimes.
Do you have your CRP tested in your routine blood tests? You could have a tendency towards inflammatory states in your family. Autoimmune or otherwise. They can present as fevers sometimes.
Yes. So far they are normal but elevated compared to my original baseline (3-5 mg/L) ever since I had those surgical implants in my body. I think that year my highest was something stupid like 25 mg/L. Right now it's still normal (9 mg/L), see the test results.
Thanks for reminding me to probably get that done next time I have a major bout of headaches. They forgot to take blood that last time.
Okay I have a question about sus moles. I went to a research study where they take a picture of one mole you think is sus, put it in an AI and then compare the AI's judgement to a panel of dermatologists' judgement. AI says it's normal but derms say it is a sus mole and needs to be removed. Nurse said to my mom it is in no way cancerous. If it's not cancerous or precancerous, why would a mole be suspicious? She didn't say it wasn't precancerous though. Do precancerous lesions make you more likely to have cancer in the future?
It pretty much looks like a normal mole but is on the bottom of my breast, has a few dark/black pinpoints and is a little uneven on the border but it's pretty subtle. I don't see how I can get skin cancer in a place that never gets sun. My grandmother did die of melanoma that had been lasered off multiple times. But her's was on her nose which got a lot of sun from gardening. My dad's cousin also had it and he had to get reconstructive surgery on his face. He worked on a farm so that's also obvious sun exposure in a vulnerable place.
But how genetic can something like skin cancer really be when UV radiation is such a big factor in it?
Melanin prevents oxidation of cells and other UV induced issues.
Low melanin -> Higher incidence of mutation from UV -> Higher skin cancer chance. Assuming you hold the amount of UV constant.
Melanin prevents oxidation of cells and other UV induced issues.
Low melanin -> Higher incidence of mutation from UV -> Higher skin cancer chance. Assuming you hold the amount of UV constant.
So I came back after some fun with the dildo session. Doctor said I looked fine but noticed I had some minor mital regurgitation not noticed on the normal ultrasound about 2 months ago. Not sure if I should be worried about that since rheumatic fever and mital heart issues run in one side of my family, any insight appreciated. Doctor just said to keep an eye on it and maybe get an ultrasound every 5-10 years.
For general dataset, male 18-35, 6ft, 135lbs.
Also my entire work department came down with COVID. Fun times for me. I got a 102 Fever but no positive result lol.
Vent. Rate : 058 BPM Atrial Rate : 058 BPM
P-R Int : 156 ms QRS Dur : 090 ms
QT Int : 436 ms P-R-T Axes : 014 080 052 degrees
QTc Int : 428 ms
Sinus bradycardia
Otherwise normal ECG
When compared with ECG of MARCH-22
No significant change was found
EF:normal
AoV:normal
MV:normal (mild myxomatous changes, trace MR)
TV:normal
PV:normal
Bubble study:negative for PFO
Vegetations:n/a
LAA: no clot
The doctor's recommendation is perfect. It's exactly what I'd suggest with a mild myxomatous change and trace regurg with a family history of MV issues. Interesting about the bradycardia. Are you ridiculously fit and into cardiovascular exercise (running, skiing, etc...?) If not, that could be of concern. If you are, then that is perfectly normal.
Okay I have a question about sus moles. I went to a research study where they take a picture of one mole you think is sus, put it in an AI and then compare the AI's judgement to a panel of dermatologists' judgement. AI says it's normal but derms say it is a sus mole and needs to be removed. Nurse said to my mom it is in no way cancerous. If it's not cancerous or precancerous, why would a mole be suspicious? She didn't say it wasn't precancerous though. Do precancerous lesions make you more likely to have cancer in the future?
It pretty much looks like a normal mole but is on the bottom of my breast, has a few dark/black pinpoints and is a little uneven on the border but it's pretty subtle. I don't see how I can get skin cancer in a place that never gets sun. My grandmother did die of melanoma that had been lasered off multiple times. But her's was on her nose which got a lot of sun from gardening. My dad's cousin also had it and he had to get reconstructive surgery on his face. He worked on a farm so that's also obvious sun exposure in a vulnerable place.
But how genetic can something like skin cancer really be when UV radiation is such a big factor in it?
Well, the AI's aren't perfect. Moles become sus when they meet certain criteria. If it is more than one color, if it is larger than a certain size, if the coloration is uneven or patterned, if it is raised instead of flat, if the borders (shape) is irregular (not representing a circle, ellipse, oval, etc...). It's part of a scoring system. If it all adds up above a certain number, given the features, or one of the features is really outside the normal, it is considered sus. One can't say if anything is precancerous without an actual biopsy since that has to be determined at the cellular level and by DNA analysis by a pathologist. The most one can usually say by visual appearance is if it is sus, normal, or seriously problematic. The ones that are seriously problematic are usually ones that if you see them, you know with 99% certainty they are cancer, and they look like really weird crap. But, even then, one can't say it is cancerous with absolute certainty without a biopsy and pathological analysis. One can't diagnose melanoma on sight alone. Basal cell carcinoma and squamous cell carcinoma, even if classic in presentation, also can't be diagnosed by sight. One would also need pathology to identify it at the cellular level and typically with DNA analysis, although classic examples are easier to identify as suspect on visualization.
To understand what precancerous is I'll have to explain a little bit of how cancer biology works. The predominant theory of cancer is that it requires multiple hits or multiple insults to occur, and the types and severity of insults determines what it takes for a cell to become cancerous, and possibly what type of cancer sub-type it can become and how aggressive it is. But, to keep it simple we'll just use the first part of the theory, which is multiple insults.
So, for a given cell, let's say it takes 4 separate insults for it to turn into cancer. A cell with no insults is a normal cell, a cell with 1 to 3 insults would be considered precancerous, since it is no longer a normal cell, but isn't perverted enough to be an actual cancerous cell, with the number of insults indicating how far along the pathway it is to becoming a true cancerous cell. A cell with 4+ insults would be a true cancerous cell. So precancerous with the multi-hit hypothesis is a cell that isn't normal, but isn't cancer either. A precancerous cell may take additional hits and become cancer, but it can never go back to being a "normal" cell. It is possible that the body will detect that the cell isn't exactly normal and it can tell the cell to commit suicide (known as apoptosis), and that stops it from progressing on the pathway and the chance for it to become cancerous is gone. It is also possible that the cells own internal sensor system will detect there is a problem and also tell the cell to commit suicide, and that again abrogates the risk of the precancerous cell become cancerous. Another possibility is that if the internal sensor system has been disabled from an insult, and the pathway for being told to commit suicide by the immune system has been disabled by another insult, the immune system can just outright murder that cell, and again the risk is gone. So, any time before a cell becomes truly cancerous, it can die or be killed off, and there is no longer any risk. It is also possible that even a cancerous cell may be detected by the immune system and be told to kill itself, of if it fails to listen, outright murdered. So, a precancerous cell is just the possibility it may become cancerous in the future, it is not a guarantee, although it is a risk, and the further along the path to cancer it is, the greater the risk.
Despite sun exposure being a major and common risk factor for melanoma (the type of skin cancer caused by nevi [moles] that go bad), it is not the only risk factor and moles that never see the sun can also become cancerous melanomas. The list of things that can insult a mole and cause it to become a melanoma are ridiculous, and that list isn't even completely known. I wish doctors would emphasize this to more people. Sun exposure is not an absolute risk factor for melanoma, this is why everyone should get a complete skin check every few years, if not once a year if they meet certain criteria such as having extremely fair skin, having many moles or freckles, having very light blonde hair or red hair, etc... As far as the genetic risk factors for melanoma, it's really complicated. It's unfortunately not as simple as testing for other major cancer types. The understanding of genetic risk factors for melanoma are very nascent and there is far more to be learned. On balance, our current understanding of melanoma indicates that environmental factors are a greater contributor to the development of melanoma than genetics. However, given our lack of understanding regarding the genetic risk factors for melanoma, that may change. However, at this time, as I said above, the inherited genetic contribution is understood to be a lesser factor.
