I just got a Surefire Ryder 22-S. Picked it up Monday. I really liked the overall package with it coming with a suppressor pouch and disassembly tools. I wanted a can that was user serviceable since .22lr is notoriously dirty. I just got a Franklin Armory F22 pistol, which is basically a Ruger 10/22 copy, though of a higher quality than a stock Ruger 10/22, and it comes with a binary trigger pack. So it has a selector switch that goes from safe, to standard semi-auto, to binary mode where it will fire on the pull of the trigger AND when you release the trigger.
The Ruger Mark IV (or any pistol in the Ruger Standard/Mark series) are basically the gold standard for semi-auto .22lr pistols, but there are some others that are good. The Browning Buckmark is another good option. I've heard good things about the Taurus TX22, especially the Competition model.
I'd highly suggest checking out Silencer Shop's website. They have a section for just rimfire suppressors. The individual pages for each suppressor will give you the specs, what they're rated for, and even what materials they're made of. Some personal suggestions are the Surefire Ryder 22-S, the Energetic Armaments Nyx 2.0, the SilencerCo Switchback, and the Griffin Armament Checkmate HD and Optimus Micro.
Edit: Shhh!
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