FYI: Ambien/zolpidem is so close to being a benzodiazepine, like Xanax/aprazolam, that it not only binds to the exact same part of the exact same receptors on your neurons, and exerts the exact same effect when it does, but also has the
exact same tapering protocol (legging out to diazepam and then slowly lowering your dose). This has been confirmed via comprehensive systematic review as recently as 2022. The physical structure of the molecule is quite different but its physiological effects are virtually identical.
"I didn't know you could have a reaction to AMBIEN" is, for all intents and purposes, him accusing both his doctor and pharmacist of unconscionably severe malpractice. In truth this would have been reiterated to a tiresome degree by both of them, both verbally and in writing. If Mexico is anything short of an unprecedented 4th world country he has, somewhere in his tin shack, a piece of paper explaining this at exhaustive length.
His self-described "ten nightly awakenings" is also almost a guarantee he has not just sleep apnea, but a severe case of such that's probably Central Sleep Apnea, the worst form of it. I literally warned him about this many times in chat starting in 2021 and he acknowledged this warning and mocked me for it, for the record.
Dr Crispy here. Pretty sure Ambien (and the other Z-drugs) causes the same brain retarding (and the same feelings) as drunkenness. It reduces the activity of your GABA neurotransmitters, making your slur your speech, uneasy on your feet, lose impulse control, quicker to anger but also easier to please etc etc.
That's why it's supposed to only be prescribed for the very short term and only the most exceptional cases of insomnia. It's 6 beers in a pill. It's also why it's one of the most abused prescription drugs.
Calling it. I think the ambien-arc is where the story ends. In an already drunken stooper he'll take a whole sheet and not wake up.
Speaking as a "true and honest" "Dr House" here, per
his explicit and repeated aspersions a few weeks ago, I can't totally fault my mensch for redosing his shitty zolpidem. It's a dirty (i.e. has MANY off-target effects) drug that is very outdated and is only first-line therapy in a third-world shithole like Mexico. The half-life on that 30-year-old slop is so short it will truly wear off less than halfway through a regular person's sleep cycles, which is why es/zopiclone is first-line therapy in a real country for this indication and why he might feel the need to take a second partial dose so he can sleep through the entire night.
It's true that (dogshit) GABAergics like Ambien/zolpidem cause your body to endocytose their baseline GABA receptors (i.e. "sucking it all up" much like
@theralph describes Faith Vickers' ass doing re: his 3"er on his revenge porno tape). It also frequently causes extremely severe sleep-disordered behavior and complex hallucinations that lead to the single worst form of "sleepwalking", sleepdriving, which can easily kill you dead. That's why real doctors prescribe real drugs in such cases. DO NOT TAKE ZOLPIDEM. DEMAND ESZOPICLONE.
It does the exact opposite of what you are saying.
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Correct. Despite being a very different molecule, zolpidem exerts roughly the same binding affinities on BZD-receptors on A-1 subunits of GABA-A receptors. Do not take this drug, for real. It's outdated and shitty and will hurt you. DM me and I'll go into far greater sperg length on this topic. Suffice it to say, absent this, you should talk to your doctor about eszopiclone, which is literally better on every single conceivable front. More effective and far fewer side effects. I've edited this post 200,000 times and can't even keep track of how repetitive this point is, but demand eszopiclone/Lunesta regardless. I'd recommend a non-GABAergic like trazodone anyway, which is a SARI and doesn't bind to that cursed tolerance-accruing place at all, but it is what it is, I guess. 'Just Say No' to zolpidem, t. Nancy Reagan, kinda-sorta.
he just goes from sober to completely fucked the minute he takes a small amount of medicine
Generally true, but be careful, because some drugs are actually "prodrugs" that are SUPPOSED to be processed into something else by the liver so that they become clinically active. Prednisone, one of the things that could have treated his gimp-arm, is a basic example of this, which needs the liver to turn it into prednisolone to exert a real effect (this is why I told him to ask his doctor about methylprednisolone, specifically, since his liver is buckbroken via decades of alcohol abuse and might not be able to carry the torch).
@AltisticRight @Dyn @Third World Aristocrat based on what I read in the Rekieta thread a few months ago I think at least one of you knows
way better than me and I'd appreciate any applicable correction and/or backup. Sorry for the notification but this is a total nightmare. Don't care if you make me look like a moron, have at it, please. Biochem was frankly never my strongest suit. No need to respond if I've missed my guess, but also please for once don't troll, I mean you Dynastia, because I'm actually worried about my retard pet piglet literally killing himself over this
