Google Chrome is rolling out a new version of their extension format which specifically kneecaps ad blockers. More to the point though, they have an official extensions marketplace. Average users aren't going to find an extension outside of that; those who do will be warned several times that installing it could make their computer spontaneously combust.
To be more specific, they'll be deprecating Manifest v2 extensions and only leaving Manifest v3, which was castrated from functions that made extensions like uBlock Origin work as efficiently as they do. This is more the case of Google cutting out a few API elements to hinder adblocking.
However there are two ways of getting out of it:
First is making uBlock Origin for Manifest v3 if it'll end up being possible to implement ad blocking via Manifest v3. Raymond Hill is already working on something like that in form of uBlock Origin Lite. It's still a massive work in progress but it shows that there is hope for adblocking on Manifest v3.
Second is that developers of Chromium based browsers, such as Vivaldi, Brave and Opera, will implement some sort of workaround themselves, depending on how Google will go about axing Manifest v2. And if everything else fails, the three browsers I've mentioned have their own ad blocker. They might not be as effective or robust as uBlock Origin but they do work.
But as far as fucking with 3rd party extensions go, there's only two ways it can go. Someone fools an extension maker into handing over the project and then pushes malicious code to it, or Google simply removes the extension from their store, which is the only way you can easily install extensions in Chrome. They've axed AdNauseam because of how much profit loss it was bringing Google, and they've axed Coincidence Detector due to it's antisemitic nature.
And unfortunately, if you want to reach the normies, you want your extension to be a click away. For most normies installing an adblocker in Chrome is already an alien concept, so imagine if you were to try and tell them how to sideload one. Especially in Chrome, where Google locked down sideloading a lot. And you sure as hell won't convince them to switch to anything else.