The only real lore question I have is this: after someone like Krauser transforms his arm, can he transform it back? Could Simmons ever go back and work a desk job again?
The evil characters are all aha! Look at this shit! *fuses to wall in a cave, flails tentacles around*
What if they win? Would Excella be stuck being a gross tentacle plant that can't move around?
It is a recurrent trope in the series and depending on the character, it may or may not make that much sense.
Lets see each example of this, that I can recall at least.
1- Birkin was dying from the bullets and he legit expected that the G-Virus would help him. Clearly it didnt as it turned him into that monstrosity where there was almost nothing mentally left of Birkin.
2- Its possible that Krauser could restore his arm back to normal once he was done killing Leon. He really seemed very confident it would work so I doubt he didnt expect that stuff to "retract" back and he would probably have to wait for his arm to grow back possibly. Then again, maybe not as well.
3- Saddler had his plans foiled and his cult was in shambles so I doubt he gave that much of a shit and REALLY wanted to make the american pay for this. Tho his confidence could imply he would have been able to somehow go back to normal but Im not sure.
4- The weapons dealer dude, he already seemed to have a couple of screws loose and Jill clearly threatened him to either take the plagas because getting arrested would probably just lead to Wesker and her getting him killed in prison and Im very sure the dude also saw him turning into a monster as him getting back at the world that always underestimated him (or something around those lines). It wouldnt surprise me if he believed that maybe Jill/Wesker might have been able to cure him if he somehow won.
5- Excella was infected against her will and, honestly, its difficult to imagine she is still mentally there and not just a bunch of plagas. She really doesnt come off to me as the type to do this manuever willingly, probably prefering to get arrested and get bailed out with her resources...not that Wesker was willing to have her getting taken and possibly talking.
6- Simmons was also infected against his will and Im still confused as to why he seemed to be mostly in control of his monstrous self while other characters completely lost themselves or were just barely holding on (like Piers). It was part of a revenge scheme so its even more unlikely that he would be given some version of the virus that would allow this level of control. And Simmons didnt have any sort of contingency in his bloodstream for this situation. I mostly blame this on RE6 shotty writing and the need to have Simmons be a final boss despite him being a very "human" threat all the way through.
7- Iirc, Lucas Baker was a psychopathic freak of which getting infected with the mold simply made him worse. He was given control back at some point before RE7 and he was mostly faking being mentally under Evilene's control (idk how the now ancient looking brat didnt notice it but I digress). With all of this said, it does make sense for him to do a hail mary and just monster-fy himself to fight Chris as Im very sure he didnt care anymore, he was just deranged.
As far as I know as of the current timeline the only humanoid BOWS that have allowed themselves to be taken by the BSAA have been Ethan and Evangeline Winters.
There is also that singing girl from The Darkside Chronicles.