Confirmed (sorta, you can down him for items, but I haven't heard of anyone perma-killing him for an area):
Move aside, Mr. X—there's a new giant, terrifying stalker in town.
www.pcgamer.com
You're gonna be more disappointed by the enemies they've cut out.
They removed the giant spiders and the Grave Digger. i.e. The giant worm boss.
If you beat it on Hardcore mode, it unlocks Nightmare difficulty, which changes up the enemy and item placement.
There's allegedly a fifth one above Nightmare called "Inferno" that ramps up the difficulty even further but I haven't seen anyone talking about it besides reddit.
I do agree that the game is rather lacking in replayability beyond two playthroughs (when I get around to playing this, I'll start on Hardcore, then again on nightmare), no way am I playing resistance, online play isn't my forte.
Although, apparently you can complete ingame challenges that allow you to purchase weapons and items to enhance Jill's abilities and make subsequent playthroughs easier. Neither does it include the alternate endings, or decisions that change how certain parts of the story play out. I have mixed feelings on DLC. It's already sixty dollars, adding DLC to make it a little more complete would put it at around ninety dollars if we're including tax (assuming they make a season pass or deluxe edition to sell it all in a bundle). I'm not sure what they could add in either. Sure, they could package and sell the mercenaries mode as DLC, but considering it was free with the og RE3 it'd probably draw a fair bit of ire from people. The rumored new game plus mode would have added a fair bit to the replay value, but I haven't heard anything about it in the reviews so I'm not even sure if it exists. I'm hoping that future DLC is for the most part free like Not a Hero for RE7, but they're probably gonna sell most of it if they do make it.
There's a day one patch planned for RE3, but it just seems to take care of bugs. I'm still excited to play this, I just know that I'm getting into a re-imagining rather than a remake of Resident Evil 3.