Yeah. There's a lot more annoying females in Trek than Keiko.
Don't forget, for marrying into the O'Briens, she got tortured too. Her husband got possessed and tormented her on TNG - then she got turned into a kid and had to deal with all that.
https://youtube.com/watch?v=F2H_OAIhrhU
Nobody was safe! Mollie had to undergo a time displacement growth arc, and even little Kirayoshi had to get stuffed into Kira and come out her cunt instead of his human mother's.
The curse runs deep on the O'Brien bloodline. If anything it's amazing Keiko is so well adjusted.