Heroine's Quest: The eponymous heroine is rescued from the avalanche and finds something to eat. She then wanders out into the woods to see what's out there. A wolf attacks her, she slays it and takes its pelt. However she doesn't have the right sort of knife to cure it and refuses to drape it over herself in its current shaggy and matted state. She begins to feel a bit cold. In the evening, she's jumped by a troll near a glowing willow tree and runs back to town. But the intense cold and the sudden physical exertion is too much for her. She manages to evade the troll and clamber over the city walls but then collapses in a heap five feet from a place of warmth and safety and dies needlessly of frostbite. The Big Bad manages to kick-start Ragnarok. The gods are defeated. Heat death of the universe ensues.
Elite Dangerous: Having traded, smuggled, and bounty-hunted his way to a nice shiny new Imperial Courier, and having had its normal-space thrusters given a warranty-voiding modification, Commander [insert name here] decides to test out its much-vaunted speed and ultra-lightweight carbon nanotube construction by attempting to boost out of the space station on full throttle. He lifts off and accelerates to 620 m/s in the blink of an eye then realises that his trajectory is all out of goose. He collides with the aperture to the docking bay and explodes ignominiously. The rest of the galaxy completely fails to care in any way whatever other than his mates, who secretly guffaw at his foolishness.
Nethack: Ser Wankpuffin the knight sidesteps to his left, failing to notice a pit immediately there. The pit is lined with razor sharp spikes, which are poisoned, and the poison is instantly lethal. He does not want his possessions identified.
Mass Effect: Commander Shepard, having failed to pass his Mako driving test, decides it'd be fun to treat the clifftop road on Noveria as a rally course. He slides off the edge to his doom. The Reapers devour all life in the galaxy.
King's Quest V: Graham eats a pie. For reasons that are too complicated to explain here, this means he cannot defeat the big bad many frustrating hours later.