Put a couple of hours into the game, made it to Edgewater, and got Parvati as a companion.
Maybe it's because I'm playing on a standard Xbox One, but the graphics look a bit blurry in some areas, particularly the foliage. I know visuals aren't everything and that this is technically a AA game, but I'm finding it to be kind of distracting out in the wilderness.
The combat is... mixed, to say the least. I think that the Tactical Time Dilation mechanic is a nice alternative to VATS, and I like how you can weaken enemies by shooting them in the balls (a nice callback to the first two Fallout games). However, the shooting feels stiff and the enemies feel too bullet spongy (particularly stings since I'm using a shotgun). Maybe I need to find better weapons and put more points into my combat skills, but so far I find the combat worse than Fallout 4's.
When we get into more of the RPG side of things, I think the game finds its footing there. The dialogue options have decent variety in them, there are skill checks a plenty, there are several different options to tackle quests, and the attributes all feel viable so far (nothing as useless as Charisma in New Vegas). I still need to see how the reputation and faction systems function, but so far this game definitely ticks off the RPG boxes.
All in all, I'm liking what I'm seeing so far. Rough combat and visuals aside, I think this is gonna be a good time.