There was another Fantastic Four villain, called "The Quiet Man" who went beyond Doom in the absurd pettiness stakes. A genius that had created a vast business empire that he controlled anonymously through various aliases and false identities, aided by the appearance altering "nanite facial reconstructor" he'd invented for himself, to the point he'd forgotten his original name. He was going after the Four, engineering troubles for them all the way back just because in college he had fallen for Sue Storm from afar but was unable to work up the nerve to talk to her, only for Richards to talk to her first. That and he considers Reed's brand of super-science to just be too flashy for his tastes. After being gloated at in a slightly more subdued way than the average supervillain who finally has the target of his ire at their mercy, Reed points out the Quiet Man's has made many scientific advances, but only for a petty revenge plan, with his genius he could have made advances that benefitted humanity instead of himself. The Quiet Man claims he did develop a workable cure for cancer but destroyed it because he figured, there's already too many people around, and eh, why should he do anything that could make other people happy when he isn't?