If he did Oxygen Not Included (or Don't Starve) he would say "I DIDNT KNOW THAT" and "THATS BOOLSHIT" so many times.
"Wait what?! Did you see that?! The Duplicant pissed himself. Huhu! He pissed himself! Oh ma gad. Look! Ack ack ack ack. And now it's dripping in the water reservoire! Oh ma gad! Uuuuuh, what should I do? *looks in chat* I guess that's not good, huh?""
"Uuuuuuh. I have no more food. *looks in chat* Uuuh, where should I get food from? Uuuuh, I don't see anything in my building bar (it's right there). Uuuuh. *looks in chat* Peepuul in chat are saying I should do some research. You can do research? Aaaah, there's a research button. It didn't work. I press the buttons but it didn't work. Look, I press the button. I guess a grey button means it won't work. I press it. Uuuuh."
"You know it's really stupid game design if they force you to get a new Duplicant every few minutes. I mean I don't even produce food yet and I already have 12 of them. So what the fuck man, this is stupid. Yeah and the ones at the lower level already suffucate, oh great. Uuuuuuuh. I don't even know what to do, why do they suffocate, this makes no sense. The game never told me they need to breath somehow. Uuuuuuuh. *leans back and does nothing* .... Yeah look, I can't do anything. How do I restart the level? Is there a button to restart the level? *looks at chat*"
"Okay peeepuul in chat are saying I need to build my machines at the top, because the oxygen goes up so I want my minions up there, right? *snort* Okay then. ... ... ... ... Wait how do I ... uuuuuh ... They don't build the machines. Uuuh. *looks at chat* They do everything but they totally ignore the machines! Ack Ack Ack! Wow. I don't know what's going on anymore, dood. What a broken piece of trash. Klei Entertainment can suck my balls. They can't even make the minions build the things I ordered them to build. Gakakaka!"
"Wait, there is hydrogen in my base, isn't it? *looks at chat* Yeah, this is hydrogen. Look, uuuuuh. Huh. *looks again at chat* How do I get rid of that? Uuuh. They can't breath hydrogen, can they? I guess they can. *looks at chat* *digs a random block* There it won't float away. It's still there. Uuuh. *looks at chat* *suddenly builds a Hydrogen
Generator* There, this should work. Ack ack ack. Now pump it baby, uh, uh, pump it. - 10 minutes later - Wait a minute the hydrogen is still there, the Hydrogen
Pump did nothing. It did absolutely nothing. The hydrogen is still there. Look. Uuuh. I guess it even produces more Hydrogen, it's even more than before, right? So you could build an infinite hydrogen source? That's cool. -5 minutes later- Oooooooh, peepuul in chat are saying I need to pump hydrogen TO the hydrogen machine, ooouuuuuuh, I didn't know that."
This is what I imagine.
Edit:
It would be boring as shit. The entire thing would be his fans thinking for him, while he bitches about how its hard, and he needs munny.
You just described every stream/playthrough since he started on Twitch.