Wuhan Coronavirus - COVID-19 Analysis & Summary - This is not just fucking pneumonia. It is everything but the kitchen sink. Lungs, heart, kidneys, liver, brain, blood vessels, testes. It affects them all.

He’s already a fat ugly autist pretending to be a woman because real women won’t touch him and he posts cartoon ponywanking fantasies online. His dad has plenty to be embarrassed about already.
In one of his visits to chat, David claimed that his Dad is also into MLP and even shares porn with David.
 
He gets his kicks on spreading doom and misery. There are quite a few people like him right now, who are emotional dark holes, getting off on people's fear. This one just happens to be an obese tranny-to-be.

Or maybe, I just felt like people deserved the truth.

Really?
So all the shit debunking your spreadsheet claim is wasted and you won't concede?
Oh I am surprised, I totally expected a fat pony fucking doomer autist that pastes Chinaland Great Wall lengths of autistic drivel to concede. I made those models because I expected David Clop to admit his autism and function as a sane human being, didn't do it because I'm fucking bored and wanted to pour salt into a wound. Boohoo wahwah muh statistics.

If you didn't catch it, that was sarcasm.

No. I already conceded that I was wrong about that part, and you were right.

That Barron's article was clickbait. Surprisingly well-disguised clickbait that most people won't recognize as clickbait, but clickbait nonetheless.

There are other articles claiming a very high R-squared where the authors fit a curve to the data:


The simple linear fitting results are shown in Figure 1. The coefficient of determination, R-squared, ranged from 0.912 to 0.999 for all clusters, which implies that the early epidemic data of laboratory-confirmed cases and deaths were largely following the linear trend. As expected, the estimated CFR of COVID-19 in Wuhan was the highest, with an overall CFR of 5.25% (95% CI: 4.98–5.51%) (Figure 1A). As shown in the figure, two different trends appeared before and after January 26, 2020. Prior to January 26, 2020, the slope (CFR) gradually increased, while it slightly decreased afterwards. We further modelled the epidemic curve obeying the exponential growth for the time periods before and after January 26 separately. The goodness of fitting for both time periods improved compared with the linear model, with R-squared of 0.995 and 0.997, respectively (Figure 2).

You have the math skills to go out there and seriously debunk this claim. I'm not even kidding. If these fuckers are full of shit, you should set them straight. Get in touch with Dr. Melody Goodman and see how she came up with her statistical model.

I wanna know what the hell is actually going on here, and why this claim of fabricated data continues to be repeated by authoritative sources if it's false.

Pack it in, fellas. David super doesn't care. Look at him rolling with the punches. :story:

Also, holy shit. Please tell me you're lying about your income. I'm not here to A-log, I'm just unable to crunch these numbers. You make 68k a year, and live in a duplex with mommy and daddy? nigga, I make 50k a year and live in a house with my wife while paying for her to go to college full time.

How many anime figurines do you buy while whimpering about how you just can't get ahead? With the absolute state of your life, I would have much more readily believed 18k a year. Good God, you make more than twice as much money as the average American, yet you have to live with mommy and daddy because you can't figure out a budget?

No. I live with mommy and daddy because my father is an emotionally manipulative, co-dependent jerk who guilt-trips me every time I make any suggestion of moving out.

"Ohh waaaaaah, are you gonna leave me with your mother? I'll just shrivel up and blow away in the wind."

"Hey, don't you know in Europe, families have dynastic wealth because children live with their parents more often? Moving out is a scam. They just want you to pay your own set of bills."

I have suggested moving out numerous times, and this is the response I consistently get. Guilt-tripping me to stay.

I'm like, "Whatever, I guess I'll just play another thousand hours of Skyrim, then".

I was going to say you're either exceptional or lying, but on reflection, those two are not mutually exclusive.

By the by, uncle moneybags, as a thoroughly doxed pedophile ponyfag, it would behoove (behoof?) you not to shit all over your plum of a job and your longsuffering co-workers.

Plum of a job? I'm exhausted all the fucking time. My door-to-door time is frequently from 0430 in the morning to 1945 at goddamn night, for a whole week, and then, the next workweek, it's 1630 in the afternoon to 0745 in the morning the following day. It's fucking exhausting. Being under fluorescent lights all day and exposed to 105 decibel engine room noise fucking destroys your mental health. Anyone who has been in this industry for more than 15 years is some manner of vegetable, because lack of sleep and stress have destroyed their minds.

I know a guy who's so exceptional, the first thing he does, every time he gets on watch, is to start scatting.

Like singing, off-key, "Doot-doo-doooooooo!"

He's down to his last brain cell.

I showed my wife this thread yesterday, and she said "welp, he's fired."

Impossible. I know a guy here who threatened to shoot his boss in the face, right to his boss's face. He wasn't fired.

Oh, and the reason why he threatened to shoot his boss in the face was because he was a Neo-Nazi and his boss wanted to bring some African-American kid down into the engine room for show and tell as part of Big Brothers Big Sisters of America, and he was all like, "If you bring that darkie down here I'm gonna get my .45 and I'm gonna blow your head off."

Right to his boss's face.

And he still wasn't fired.

It's a union job. There's no interview or anything to get in. You just show up at job call, and they call a certain number of heads, and you're hired. I wasn't given preferential treatment. I just signed on the dotted line, and I got the job, same as everyone else in the group that was called. Simple as that.

By the way, if anyone wants to get on my ass for nepotism, gimme a fucking break. There are like several dozen people working here who are friends or family of an existing employee. Two other people in the group of 20 I got hired in were friends and family of existing employees.

Merchant Marine is rife with nepotism. It's just the way it is.

Sorry if this is late and sounds possibly disjointed, I typed this up within about half an hour late last night and had to wait until today for my account to get approved.

Oh, no, no. There is absolutely no need to apologize. I would be delighted to speak with someone who has actual biology expertise. That's what I'm here for.

For one, NCBI is a database of papers, it's good for finding papers, but it isn't ACTUALLY a journal in and of itself, the journal in question with the first link is PLOS One, which is as far as I've heard personally it's okay as a journal? But it's certainly no Nature in terms of reputation and clout. This is just me correcting your statement about it being in the NCBI database, which isn't really indicative of anything in terms of actual quality.

Oh. I thought that they generally only put papers from fairly reputable journals in the NCBI database.

Looking at the abstract of a paper simply isn't good enough, while the results section of the abstract mention histopathologic changes in the lungs, it is still best to look at the part in the actual results section that is being referred to.

We can see mentions in the conclusion that there are other studies contradicting the results of this study with regards to vector vaccines for the S protein, suggesting that this presentation may generate a response in which sensitization and by extension, immunopathology, does not occur. This was achieved using a VEE (Venezuelan equine encephalitis) vector containing the S gene (basically inserting the CoV Spike protein encoding gene into another virus). The paper even shows this as a nice little table at the very end too, this is why gleaming an abstract is a terrible thing to do, there can be evidence contradicting the evidence in other reports. In this case citation 15 is the paper in question.

https://www.ncbi.nlm.nih.gov/pubmed/16476986

I was discussing all this with a couple immunologists, and the general consensus was that a Th2 vaccine would be difficult or even impossible to make for a SARS-like virus due to the immunopathological reaction it incites in the lung tissue. There are ways around this, technically.

They can try and induce immunogenicity by other means and avoid the negative host response, of course. However, it's tricky. I was worried that the challenges involved in all this would delay a vaccine.

A number of people infected with COVID-19 who recovered from it are showing very limited antibody responses:






That's another problem. What if they give someone a vaccine, and they don't even have any antibody response at all?

There's more:



In addition, peer-reviewed research on SARS-CoV and preprint studies on SARS-CoV-2 report that some nonneutralizing coronavirus antibodies might trigger a harmful immune response upon reinfection with those pathogens or cross infection with other coronaviruses.

There's also this:



Some have suspected that SARS-CoV-2 has ADE, like Dengue. So, if someone gets a different coronavirus, and then they get COVID-19, they might have an incorrect antibody response and the antibodies may actually aid the virus in infecting immune cells.

Vaccines are also hilariously difficult to make and get approved, you need to find a balance among many different factors, you want an immune response, but not too intense of one, but you also need it to linger long enough that boosters don't have to come often, it's a tough thing and the primary funders are governments and they're stingy as fuck. The vaccine strain of the disease I work on has no less than three mutations in genes critical for infection, as an example.

The second Nature article you linked also defeats your point, look at the second-to-last paragraph. In it, it states that while CoV-2 can infect T lymphocytes (much like MERS-CoV can!), it fails to replicate in them and eventually degrades, the same occurs with PBMCs (peripheral blood mononucleic cells, jargon for lymphocytes and monocytes). If this was not the case and it was actually capable of infecting T lymphocytes, you would then see AIDS-like effects in CoV-2 (it is well known that HIV targets Th cells, a group of T lymphocytes), but you don't.

Infecting cells is all well and good, but if it just gets stuck in there and fails to replicate, the damage will come primarily from the immune system as infected cells may flag themselves as infected. Why this happens in some cells and not others is a massive topic as a whole and it's not something I'm well-versed in so I wouldn't want to spout anything off there that may end up being misinformed.

COVID-19 patients have T lymphocytopenia. A common finding in COVID-19 is that patients' tissues have every inflammatory cytokine in them, causing severe damage and fibrosis, and they have low CD4 and CD8 counts and high Th17. The CD4 and CD8 cells that are present are hyper-activated. In other words, there is a low population of them, and the ones that are present are working overtime.

Even though it can't quite replicate in them, apparently, the virus can lure the immune system into attacking and destroying T cells. This may create a blind spot in the immune response, in a sense. It may also be contributing to the bacterial secondary infections that have been witnessed. More study of this phenomenon is needed.

From how I'm personally looking at this, in severe cases patients are primarily harmed by cytokine storms shown through massive elevation in pro-inflammatory cytokines. As mentioned in the second paper there are strategies trialled to dampen this damaging response. The paper also states that this is suggestive, but as this is still very recent research it isn't truly conclusive. It may also be indicative of a severe infection resulting in a massive immune response, they are in severe stages of infection after all.

Yep, steroids. China has been giving patients huge doses of methylprednisolone to try and dampen the immune response. This has problems of its own. You need an immune response to get rid of the virus, and if you suppress the immune system too much, you may give the virus the upper hand. Personally, I think that for the critical cases, it may be better to give them something like CytoSorb instead of steroids. It's an extracorporeal filtration device that gets rid of sepsis by absorbing excess cytokines and other crap from the blood. It's made by a company in New Jersey.



Unfortunately, this is kind of a boutique therapy that would be difficult to administer to everyone. You need a dialysis machine or an ECMO, or something else that pumps the blood out of the body, through the filter, and back in. It would have to be triaged for the most critical of cases, of course.

The filter consists of a canister full of adsorbent polymer beads with micro-pores that pull in the cytokines and junk. It was designed specifically to deal with sepsis that would ordinarily be lethal, which is a thing that happens with cytokine storms:



I'd personally want to see papers on this, but since its known that CoV-2 is capable of entering various cells, but failing to replicate in them, it seems more likely this may be a result of major inflammation and cytokine storms that are previously described.
If that's the case, it'd be good to use drugs to dampen the inflammatory response in combination with any sort of antivirals used, in which reports mentioned earlier have stated that there are currently trials in place to deal with this. This is also compounded by the fact that elevated levels of IL-6, a pro-inflammatory cytokine, is indicative of poor prognostics.

https://www.sciencedirect.com/science/article/pii/S104366182030743X?via=ihub

There's this report that I've found in that previously posted Nature article, it's talking about Tradition Chinese Medicine though so I'm not particularly sure on its legitimacy (though there are other papers mentioning anti-inflammatory effects in influenza and COPD too). There are also trials described using tocilizumab and the potential for small-molecule inhibitors too so it looks like there is progress being made in this regard, hopefully papers will get published or put in pre-print with these treatments soon.

They have more than just elevated IL-6. They have elevated IL-1β, IL-18, TNF-α, IL-6, IL-8 and IL-10, among other things. The cytokine storms this thing causes are so severe, it causes fibrosis and hemorrhagic necrosis of tissue. It can do this in the lungs, the brain, and who knows where else:

Clinical pathology of critical patient with novel coronavirus pneumonia (COVID-19) (2020-02-26) [https://www.preprints.org/manuscript/202002.0407/v3/download]

Recent study indicates that SARS-CoV-2 has the same cell entry receptor ACE2 as
SARS-CoV.12,13 Generally, ACE2 protein is expressed in alveolar cells, bronchial
epithelium and vascular endothelium, therefore SARS-CoV-2 protein binds to ACE2
would result in acute lung injury and pulmonary edema. We observed abundant
pulmonary edema and hemorrhage, desquamated bronchial and alveolar epithelial cells.
On the other side, cytokine storm links to an excessively exaggerated immune response,
and uncontrolled proinflammatory responses, which causes severe organ diseases
including lung damages.14-16 Several representative cytokines have been identified
including IL-1β, IL-18, TNF-α, IL-6, IL-8 and IL-10, which are produced and regulated
by various immunological cells including CD8 and CD4 T cells.17

Pathological findings of COVID-19 associated with acute respiratory distress syndrome (2020-02-18) [https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30076-X/fulltext]

Peripheral blood was prepared for flow cytometric analysis. We found that the counts of peripheral CD4 and CD8 T cells were substantially reduced, while their status was hyperactivated, as evidenced by the high proportions of HLA-DR (CD4 3·47%) and CD38 (CD8 39·4%) double-positive fractions (appendix p 3). Moreover, there was an increased concentration of highly proinflammatory CCR6+ Th17 in CD4 T cells (appendix p 3). Additionally, CD8 T cells were found to harbour high concentrations of cytotoxic granules, in which 31·6% cells were perforin positive, 64·2% cells were granulysin positive, and 30·5% cells were granulysin and perforin double-positive (appendix p 3). Our results imply that overactivation of T cells, manifested by increase of Th17 and high cytotoxicity of CD8 T cells, accounts for, in part, the severe immune injury in this patient.


Noncontrast head CT images demonstrated symmetric hypoattenuation within the bilateral medial thalami with a normal CT angiogram and CT venogram (Fig 1). Images from brain MRI demonstrated hemorrhagic rim enhancing lesions within the bilateral thalami, medial temporal lobes, and subinsular regions (Fig 2). The patient was started on intravenous immunoglobulin. High-dose steroids were not initiated due to concern for respiratory compromise.

Wherever the virus sets up a site of infection, it lures this massive host response that destroys healthy tissue. ACE2 receptors, the entry receptor of the virus, are basically everywhere.

Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host–Virus Interaction, and Proposed Neurotropic Mechanisms (2020-03-13) [https://pubs.acs.org/doi/10.1021/acschemneuro.0c00122]

Figure 1. Tissue distribution of ACE2 receptors in humans. Viremia (A) disseminates the COVID-19 virus throughout the body via the bloodstream (B). Neurotropism may occur via circulation and/or an upper nasal trancribrial route that enables the COVID-19 to reach the brain (C) and bind and engage with the ACE2 receptors (D, blue). COVID-19 docks on the ACE2 via spike protein (D, golden spikes). Shown are lungs, heart, kidneys, intestines, brain, and testicles that are well-known to express ACE2 receptors and are possible targets of COVID-19.

SARS-CoV-2 can get into the lungs, heart, kidneys, GI tract, brain, testes, and possibly even the blood vessels themselves, and cause massive and damaging inflammatory responses.

Vasculitis was a finding with SARS. Very serious vasculitis. Why is vasculitis absent from so much COVID-19 research? The two viruses use the same entry receptor, ACE2, and affect pretty much all of the same tissues.


The Central Nervous System
Several observations suggest that SARS-CoV is capable of causing an infection of the central nervous system. RT-PCR has detected SARS-CoV genomic sequences in cerebral spinal fluid and in brain tissue specimens (Figure 1F).40, 41, 42 The virus has been successfully isolated from brain tissue.42 Edema and focal degeneration of neurons have been observed in the brains of SARS autopsies.13, 15 IHC, in situ hybridization, and EM have confirmed viral infection of neurons.13, 15, 42 Gliocytes have also been found infected by SARS-CoV.42

The Urogenital Tract
Kidneys of autopsied SARS patients have shown focal necrosis and vasculitis of small veins in the renal interstitial tissue.12 In addition, monocytic infiltration, acute tubular necrosis, and other nonspecific changes, such as glomerular fibrosis and nephrosclerosis, have all been observed.12, 13, 17, 43, 44 Quantitative RT-PCR has detected high viral loads in the renal tissue specimens of several SARS patients.37 In situ hybridization and IHC have identified viral genomic sequences and proteins, respectively, in the epithelial cells of the distal tubules.15, 23, 30 Viral particles have been localized to the cytoplasm of these cells through EM.15 These findings may explain the presence of SARS-CoV sequences in urinary samples of SARS patients.6, 7
...
The few available studies on adrenal glands described the presence of necrosis and vasculitis of the medulla with monocytic and lymphocytic infiltration.12, 13 Viral antigens and genomic sequences have been identified in adrenal glands.23, 30 Edema of both myocardial stroma, as well as vascular walls, and atrophy of cardiac muscle fibers have all been demonstrated.12, 13

ACE2 receptors are found in the endothelial lining of blood vessels and the blood-brain barrier. What if the hypoxemia that patients are suffering with this virus is simply because vasculitis is causing the immune system to attack the walls of blood vessels and capillaries, leading to sepsis, viremia, clotting, et cetera?

What if the alveoli in people's lungs aren't exchanging oxygen due to an inflammatory and vasoconstrictive response, and pumping air into their lungs with a ventilator is useless?

They're inflating people's lungs like balloons with this damn virus, with ridiculously high PEEP settings that injure their alveoli, and they still can't oxygenate these people.

Why? Because it's in the blood and blood vessels. It can cause viremia, vasculitis, and perhaps even focal vasoconstriction by preventing the degradation of Angiotensin II, a highly vasoconstrictive and inflammatory hormone.

Please, god. Please, tell me someone understands what I'm saying here. @evrae please, please back me up on this. I feel like I'm going nuts.
 
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Dammit, I hit the character limit. Okay, Part 2.

Thanks for that.
It looks like the myocarditis described isn't unique to CoV-2, being previously described in MERS-CoV (46). There's also descriptions of autopsy findings of inflammatory mononuclear infiltrate in myocardial tissue (26, 47, 48) (this is basically cells of the immune system infiltrating heart tissue). Suggesting that inflammation is present in this tissue, which is likely the responsible cause for the damage.
There's also descriptions of arrythmias in CoV-2 cases, being attributed to things such as hypoxia (lung damage of course results in worse blood oxygenation, obviously), and inflammatory stress (something that is being found often).

It reads to me like the infiltration of cells by CoV-2 is triggering inflammation and immune responses that are compounding problems caused by the general respiratory system damage (hypoxia and such). There also suggestions in this paper that patients with CVD and hypertension have higher expression of ACE2 which consequently increases susceptibility to CoV-2 (5).

I think we're on the right track by looking at keeping the immune system/inflammation under control during infection, as it seems like the hyperactivity of it during infection might be what's causing the most damage.

Severe host response was something that was noted in SARS, as well. COVID-19 and SARS pathology are very, very similar, as best as I can tell. The key difference with COVID-19 is that SARS-CoV-2 has furin cleavage sites on its spike glycoproteins that enable highly efficient fusion with human cells. This makes it spread a lot faster than SARS-CoV ever could, and it also might enable it to infect cell lines that SARS-CoV can't, like this immunosuppressive, T-cell-destroying effect that we're seeing.

More research is needed. More data is desperately needed on the potential vascular and neurological complications, as well as this immune-system-suppressing effect.

Is he spending all his money to acquire child porn? We already know he's such a pedo that porn of childlike pastel ponies from a kid show isn't enough; he needs porn of childlike pastel ponies which are overtly in kid show canon grade schoolers.

I'm just trying to figure out his budget. Maybe we can help.

Hey, I’m not into CP. That’s fucking disgusting. Drawings are just fucking drawings. Some sicko abusing a child and filming it is a completely different story. That’s totally unacceptable.

I have a brokerage account where I sock away money, and my investments have actually consistently gained value. I made a modest amount off that. Like $1400 last year and $700 this one. My savings were doing okay, but they’re not looking so hot after I bought thousands in prepper supplies.

Also, the calculations for how much I drink are completely wrong. I don't buy $140 in liquor every month. I buy $140 in liquor like every five months. I don't do 16 fucking shots a day. I can go weeks without having a drop of liquor, and when I do drink, it's usually like between five to ten shots worth. I'll binge for one day, and then go another few weeks without anything. Most of the time, I have like one or two beers a day is all.

Most of the cash that I do blow goes into big-ticket, durable items. I'm a mechanical keyboard nut and I have a fondness for audio gear and cameras and electronic shit.

I have plenty of money. I don't have any money issues at all. I always keep a backup fund of $10,000 at minimum and never go below that.

Just finished reading the thread, and I have to say, it was a real page turner. I genuinely couldn’t put it down. I have some questions for @Drain Todger, if he would be so kind to oblige:

1. Are you under the impression that the people in this thread, or on this forum in general, are not taking the crouching tiger, hidden sniffle seriously enough? You go on and on about how dangerous or unprecedented this is, as if the people that you’re preaching to haven’t told you repeatedly that they’re taking the situation seriously, and are taking precautions.

Well, at first, maybe I did think that people weren't taking it seriously. But now, I see that they are. That's reassuring.

2. I’ve watched some of the videos that you’ve posted here, and I see you recording outside, without wearing proper PPE. Are these being filmed at your house, or somewhere else? If you’re not in quarantine at home, why aren’t you wearing proper PPE?

It's in a safe location. It was aboard a ship that's been in the shipyard for a couple weeks already. All the viruses on all the fomites are dead, and there's no one around. I've been wearing a mask to and from the job site. I have assessed the risks properly and I am taking all appropriate precautions, including spraying touch surfaces with disinfectant, not touching my face, avoiding people and their aerosols, et cetera. There's no point in wearing a mask in an open, well-ventilated space if there isn't anyone around. It's only if you're near people, or in an enclosed space where aerosols may linger in the air, that you should wear a mask outside.

3. Have you started a diet and workout regimen to reduce your weight, and thus the stress to your immune system? You’re quite clearly overweight, and your friends and family can’t benefit from your insight if you aren’t well enough to share it with them.

I'm planning on it, actually.

4. What do you do in your free time when not obsessing over this?

I like Space Engineers, Starmade, KSP, et cetera. I like doing large and complicated builds. I once did a ship in Starmade that had 13 million blocks.

RV7SFy7.png

I'm also into digital audio workstation stuff on my desktop rig. I make music. That's why my rig has 128 gigs of RAM. It needs to be able to run Spitfire and Vienna Symphonic Library. I own something like $8 to $10k in virtual instruments.


I'm a little out of practice. I need to get back into it and compose a bit more seriously. The orchestral stuff I do, I like doing layered ostinato sections and odd-meter stuff, almost like math rock. I like to experiment with uncommon sounds, textures, and rhythms. Very often, I sketch pieces simply by singing them a cappella.

One of my tics is singing improv a cappella stuff just, everywhere. Any time I'm alone and I'm not listening to music, I have to make music by singing it. If I'm in the shower, or if I'm alone at work, I'll come up with ideas for my music. Not singing or humming any particular pre-existing song, mind you, but coming up with entirely new compositions.

This is what I mean:



5. Have you been diagnosed with anything other than autism? What is your IQ?

I don't wish to comment on my exact IQ score. Suffice it to say, I am a midwit. Neither a genius nor a dummy. I'm right in that sweet spot where I play second-fiddle to the 130 and 140 IQ people while also being horrified at the mind-numbing stupidity of the average person.

Oh, look, he's an anarchist. See this is what I'm talking about. I'd love to hear about his political theory and what models he has for a successful anarchist society. I bet he's done tons of reading on the subject. He doesn't seem like the type to come to such a decision lightly.

Well, I'm into a little bit of Bakunin, a little of Kropotkin, a little Stirner, and so on, but I'm mainly into Thorstein Veblen.

A lot of people have me confused for an Anarcho-Socialist and Marxist when really, I'm more of a Veblenite/Technocrat.

I don't understand why no one ever debates it when I bring up Thorstein Veblen. His name is like the Fnords from Discordianism.

It's like, people don't see it when you say Thorstein Veblen. His name is invisible. I can say it over and over again, and they still don't see it.

Thorstein Veblen, Thorstein Veblen, Thorstein Veblen.

... and yet, I cannot find a single person willing to discuss the topic at all. It feels almost like a practical joke. Did a person named Thorstein Veblen ever really exist, or did I merely hallucinate it? I'm not sure. I keep naming him, and people keep ignoring it and calling me a Marxist.





I became an anarchist over time due to disillusionment with the state of modern society. I'm not a smashie or a tankie. I take a very dim view of people breaking shit and rioting in the street. I also have an intense dislike of authoritarianism.

I am an American, of course, and since 9/11, I have been subjected to the cavalcade of horrors that is American foreign policy. It's kind of ironic. I love weapons and military technology, but I am a pacifist and generally despise war. From one president to the next, each one promises to end the excesses and warmongering of the last one, but they don't deliver on that promise at all. The Clintoncrats went into Kosovo, and Bush was like "I'm gonna put a stop to that", and then, he started the wars in Iraq and Afghanistan. Obama was like "I'm going to end the Bush-era policies of warmongering and close Gitmo", and not only did he not close Gitmo, he started wars in Libya and Syria.

The CIA straight-up gave a pile of guns, ammo, and TOW missiles to nutcases shouting Takbirs! What the fuck did American troops die in Iraq and Afghanistan for, if we were just gonna give free weapons to another bunch of Salafi lunatics and repeat the same mistake we made when we armed the Mujahideen against the Soviets?



So, basically, American blood was spilled for nothing. We go from fighting terrorists and insurgents to arming them at the drop of a hat, and no one questions it.

Meanwhile, public services in the US are a complete shambles. Our infrastructure is decaying, people are struggling with medical debt and student debt, and yet, somehow, we have trillions of dollars to blow on these ridiculous wars that serve no purpose.

Saddam didn't have any fucking WMDs.

Afghanistan is a shithole and the Graveyard of Empires and there's no point in being there.

Gaddafi didn't do a fucking thing wrong, he was friends with Sarkozy and supported his campaign only to get backstabbed by that son of a bitch, and the so-called "responsibility to protect" was used as an excuse to invade his country. Oh, gee. I guess if American citizens started rioting and bulldozing government buildings and burning down police stations, the National Guard wouldn't fuck 'em up like they did at Kent State. Gee, I guess that means someone ought to invade us if that happened! Sovereign nations have no right to protect their own sovereignty against rebellion in their own borders. We must bomb them to rubble and deprive people of their government.

Just like we supported rebels in Syria, when people there overwhelmingly supported Bashar al-Assad. The chemical attack in Douma was a complete fabrication, and the OPCW covered up a contradictory report.


You know what I'd like to see as an American? I'd like to see my government quit spending trillions of dollars on military adventurism, and spend a little on revitalizing our goddamn country so we're no longer the laughingstock of the world.

Redevelop and repair the goddamn infrastructure, dammit! They're letting everything fall to fucking ruin!


More than 50,000 bridges across the U.S. are falling apart and endangering drivers, according to a new report.

NBC News found cases from Florida, Georgia, Michigan and other states where pieces of crumbling bridges broke off and fell to the roadway, sometimes hitting vehicles.

In Utah, driver Mike Peterson escaped serious injury when a chunk of a bridge smashed through his windshield as he drove underneath.

And that's just to start. I could tell you all sorts of shit about capitalism, conspicuous consumption, planned obsolescence, the throwaway economy, all that, but I'll try and summarize it in just a couple sentences.

Basically, Chinese sweatshop workers make useless fucking plastic trinkets that smell like old car tires, and then they load them on a container ship burning disgusting bunker fuel, and then, that ship comes into port in the US and that shit gets distributed to every Walmart so every dumbass mouth-breathing American can proffer their credit card at the register and go into fucking debt to own more useless plastic junk. This plastic junk is then thrown away in the space of about a year, where it ends up in a landfill, or dismantled by Malaysian children ripping toxic garbage apart with their teeth. All the money goes to China so Xi Jinping can buy more dragon dildos, I don't know.

Basically, I am an anarchist because I realize that I'm living in the prequel to Idiocracy and Wall-E, and I would like to tear this system down before the literal garbage mountains begin to appear.

Yes, yes, I realize that I'm a consoomer. You don't have to pull that "LOL why do you have electronics then?" thing.

I repair all my stuff. I have a soldering iron and bit driver sets. I hardly ever throw anything away.

And I don't buy junk, either. I buy only the best.

Anyway, I've been shifting more towards Classical Liberalism lately because I realized that my anarchist friends were brain-dead morons who didn't give a fuck about the virus and actively shunned me for my very reasonable concerns about it.

Fuck it. I may as well get into investing, make my money, and enjoy myself, and fuck everyone else. Fuck 'em. Altruism is worthless at this point.

I mean, look. They're nominating Joe Biden. Joe Biden. That retarded kiddie-fiddling, demented fucking freak.


Durr, dey rub mah leg down!

Okay, grandpa.

There is only one thing to do, this coming election. Bring the fucking popcorn. Bring all of it.
We are about to witness levels of salt and butthurt and insanity never-before-seen. This is going to be the stuff of legends. :popcorn:

Allow me to introduce you to a stunning new concept that you may not have been to: convergent evolution. Environmental pressures will select for specific behaviors, morphology, and diet given certain conditions. In animals, the convergence on a similar form, behavioral pattern, and diet of unrelated groups can be seen with the old grouping of anteaters with aardvarks and pangolins in the now defunct order Edentata due to their collective lack of fully developed teeth, insectivorous diet, and large digging forelimbs.

Presuming that viruses are quasi-living entities, they too would be subject to the whim of environmental factors in their fate. The polyphyletic nature of the group you listed - a retrovirus, a filovirus, and a herpesvirus - all seem to display the ability to infect immune cells, so that may confer some benefit in their ability to persist and propagate within a host. To say that SARS-2-CoV is in someway related to them beyond the broad category of virus because of this ability is not a tenable position.

By the by, viral infectivity in immune cells is what causes the dreaded cytokine storm, which something as mundane as H1N1 influenza can and will do.

I'm no biologist nor a virologist, but my field - geology - is an interdisciplinary field; you learn the basics of the other fields. The core tenents of science are applicable to each and every science.

I wasn't trying to imply that SARS-CoV-2 was related to any of those viruses. Rather, what I was suggesting is that direct immune-suppression (rather than mere avoidance of immune responses) is a trait of some of the most vicious viruses out there. We have to be wary of this thing.

Herpes and Epstein-Barr can avoid immune responses by trying to hide from immune surveillance and going dormant. Ebola and HIV are nasty, but herpes and EBV are fairly common infections that are only really an issue if someone has a weak immune system and they're roused from their dormant state.

SARS-CoV-2 is neurotropic. What if it can hide and go dormant in nerves like herpes? What if it never goes away? We need answers to these questions.

Good point! That's a post I didn't notice.
There are some traits or behaviors that develop in evolution very often generally because they're a net gain regardless.
In a pathogens case, having some form of dealing with the immune system in some way is pretty critical to be successful and propagate further within the host.
This issue can be approached in different ways, for some, you can simply survive within phagosomes by some means or another, avoiding immunosurveillance by preventing digestion and subsequent antigen presentation. Some go for a more direct approach and just outright infect cells of the immune system.
As you've said yourself, this is something influenza can pull off, and so can MERS-CoV, it's not something unusual in this case from the sounds of it.
Avoiding detection is a critical thing in just about any disease, even cancer conducts this by various different means.

This is a hugely complex field though, and I'm largely unfamiliar with infection methods from diseases that aren't the ones I research so I won't regard myself as an expert in things other than the stuff that I actually do work on.

I was discussing the ways this virus avoids immune surveillance with WesternBlotter, a PhD immunologist, and he was seriously creeped the hell out by this thing.

You have no idea how happy I am that a few people on here actually understand the terminology and what I'm getting at with this thing.
 
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Or maybe, I just felt like people deserved the truth.



No. I already conceded that I was wrong about that part, and you were right.

That Barron's article was clickbait. Surprisingly well-disguised clickbait that most people won't recognize as clickbait, but clickbait nonetheless.

There are other articles claiming a very high R-squared where the authors fit a curve to the data:




You have the math skills to go out there and seriously debunk this claim. I'm not even kidding. If these fuckers are full of shit, you should set them straight. Get in touch with Dr. Melody Goodman and see how she came up with her statistical model.

I wanna know what the hell is actually going on here, and why this claim of fabricated data continues to be repeated by authoritative sources if it's false.



No. I live with mommy and daddy because my father is an emotionally manipulative, co-dependent jerk who guilt-trips me every time I make any suggestion of moving out.

"Ohh waaaaaah, are you gonna leave me with your mother? I'll just shrivel up and blow away in the wind."

"Hey, don't you know in Europe, families have dynastic wealth because children live with their parents more often? Moving out is a scam. They just want you to pay your own set of bills."

I have suggested moving out numerous times, and this is the response I consistently get. Guilt-tripping me to stay.

I'm like, "Whatever, I guess I'll just play another thousand hours of Skyrim, then".



Plum of a job? I'm exhausted all the fucking time. My door-to-door time is frequently from 0430 in the morning to 1945 at goddamn night, for a whole week, and then, the next workweek, it's 1630 in the afternoon to 0745 in the morning the following day. It's fucking exhausting. Being under fluorescent lights all day and exposed to 105 decibel engine room noise fucking destroys your mental health. Anyone who has been in this industry for more than 15 years is some manner of vegetable, because lack of sleep and stress have destroyed their minds.

I know a guy who's so exceptional, the first thing he does, every time he gets on watch, is to start scatting.

Like singing, off-key, "Doot-doo-doooooooo!"

He's down to his last brain cell.



Impossible. I know a guy here who threatened to shoot his boss in the face, right to his boss's face. He wasn't fired.

Oh, and the reason why he threatened to shoot his boss in the face was because he was a Neo-Nazi and his boss wanted to bring some African-American kid down into the engine room for show and tell as part of Big Brothers Big Sisters of America, and he was all like, "If you bring that darkie down here I'm gonna get my .45 and I'm gonna blow your head off."

Right to his boss's face.

And he still wasn't fired.

It's a union job. There's no interview or anything to get in. You just show up at job call, and they call a certain number of heads, and you're hired. I wasn't given preferential treatment. I just signed on the dotted line, and I got the job, same as everyone else in the group that was called. Simple as that.

By the way, if anyone wants to get on my ass for nepotism, gimme a fucking break. There are like several dozen people working here who are friends or family of an existing employee. Two other people in the group of 20 I got hired in were friends and family of existing employees.

Merchant Marine is rife with nepotism. It's just the way it is.



Oh, no, no. There is absolutely no need to apologize. I would be delighted to speak with someone who has actual biology expertise. That's what I'm here for.



Oh. I thought that they generally only put papers from fairly reputable journals in the NCBI database.



I was discussing all this with a couple immunologists, and the general consensus was that a Th2 vaccine would be difficult or even impossible to make for a SARS-like virus due to the immunopathological reaction it incites in the lung tissue. There are ways around this, technically.

They can try and induce immunogenicity by other means and avoid the negative host response, of course. However, it's tricky. I was worried that the challenges involved in all this would delay a vaccine.

A number of people infected with COVID-19 who recovered from it are showing very limited antibody responses:






That's another problem. What if they give someone a vaccine, and they don't even have any antibody response at all?

There's more:





There's also this:



Some have suspected that SARS-CoV-2 has ADE, like Dengue. So, if someone gets a different coronavirus, and then they get COVID-19, they might have an incorrect antibody response and the antibodies may actually aid the virus in infecting immune cells.



COVID-19 patients have T lymphocytopenia. A common finding in COVID-19 is that patients' tissues have every inflammatory cytokine in them, causing severe damage and fibrosis, and they have low CD4 and CD8 counts and high Th17. The CD4 and CD8 cells that are present are hyper-activated. In other words, there is a low population of them, and the ones that are present are working overtime.

Even though it can't quite replicate in them, apparently, the virus can lure the immune system into attacking and destroying T cells. This may create a blind spot in the immune response, in a sense. It may also be contributing to the bacterial secondary infections that have been witnessed. More study of this phenomenon is needed.



Yep, steroids. China has been giving patients huge doses of methylprednisolone to try and dampen the immune response. This has problems of its own. You need an immune response to get rid of the virus, and if you suppress the immune system too much, you may give the virus the upper hand. Personally, I think that for the critical cases, it may be better to give them something like CytoSorb instead of steroids. It's an extracorporeal filtration device that gets rid of sepsis by absorbing excess cytokines and other crap from the blood. It's made by a company in New Jersey.



Unfortunately, this is kind of a boutique therapy that would be difficult to administer to everyone. You need a dialysis machine or an ECMO, or something else that pumps the blood out of the body, through the filter, and back in. It would have to be triaged for the most critical of cases, of course.

The filter consists of a canister full of adsorbent polymer beads with micro-pores that pull in the cytokines and junk. It was designed specifically to deal with sepsis that would ordinarily be lethal, which is a thing that happens with cytokine storms:





They have more than just elevated IL-6. They have elevated IL-1β, IL-18, TNF-α, IL-6, IL-8 and IL-10, among other things. The cytokine storms this thing causes are so severe, it causes fibrosis and hemorrhagic necrosis of tissue. It can do this in the lungs, the brain, and who knows where else:

Clinical pathology of critical patient with novel coronavirus pneumonia (COVID-19) (2020-02-26) [https://www.preprints.org/manuscript/202002.0407/v3/download]



Pathological findings of COVID-19 associated with acute respiratory distress syndrome (2020-02-18) [https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30076-X/fulltext]






Wherever the virus sets up a site of infection, it lures this massive host response that destroys healthy tissue. ACE2 receptors, the entry receptor of the virus, are basically everywhere.

Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host–Virus Interaction, and Proposed Neurotropic Mechanisms (2020-03-13) [https://pubs.acs.org/doi/10.1021/acschemneuro.0c00122]



SARS-CoV-2 can get into the lungs, heart, kidneys, GI tract, brain, testes, and possibly even the blood vessels themselves, and cause massive and damaging inflammatory responses.

Vasculitis was a finding with SARS. Very serious vasculitis. Why is vasculitis absent from so much COVID-19 research? The two viruses use the same entry receptor, ACE2, and affect pretty much all of the same tissues.




ACE2 receptors are found in the endothelial lining of blood vessels and the blood-brain barrier. What if the hypoxemia that patients are suffering with this virus is simply because vasculitis is causing the immune system to attack the walls of blood vessels in the capillaries, leading to sepsis, viremia, clotting, et cetera?

What if the alveoli in people's lungs aren't exchanging oxygen due to an inflammatory and vasoconstrictive response, and pumping air into their lungs with a ventilator is useless?

They're inflating people's lungs like balloons with this damn virus, with ridiculously high PEEP settings that injure their entirely compliant alveoli, and they still can't oxygenate these people.

Why? Because it's in the blood and blood vessels. It can cause viremia, vasculitis, and perhaps even focal vasoconstriction by preventing the degradation of Angiotensin II, a highly vasoconstrictive and inflammatory hormone.

Please, god. Please, tell me someone understands what I'm saying here. @evrae please, please back me up on this. I feel like I'm going nuts.
Dammit, I hit the character limit. Okay, Part 2.



Severe host response was something that was noted in SARS, as well. COVID-19 and SARS pathology are very, very similar, as best as I can tell. The key difference with COVID-19 is that SARS-CoV-2 has furin cleavage sites on its spike glycoproteins that enable highly efficient fusion with human cells. This makes it spread a lot faster than SARS-CoV ever could, and it also might enable it to infect cell lines that SARS-CoV can't, like this immunosuppressive, T-cell-destroying effect that we're seeing.

More research is needed. More data is desperately needed on the potential vascular and neurological complications, as well as this immune-system-suppressing effect.



Hey, I’m not into CP. That’s fucking disgusting. Drawings are just fucking drawings. Some sicko abusing a child and filming it is a completely different story. That’s totally unacceptable.

I have a brokerage account where I sock away money, and my investments have actually consistently gained value. I made a modest amount off that. Like $1400 last year and $700 this one. My savings were doing okay, but they’re not looking so hot after I bought thousands in prepper supplies.

Also, the calculations for how much I drink are completely wrong. I don't buy $140 in liquor every month. I buy $140 in liquor like every five months. I don't do 16 fucking shots a day. I can go weeks without having a drop of liquor, and when I do drink, it's usually like between five to ten shots worth. I'll binge for one day, and then go another few weeks without anything. Most of the time, I have like one or two beers a day is all.

Most of the cash that I do blow goes into big-ticket, durable items. I'm a mechanical keyboard nut and I have a fondness for audio gear and cameras and electronic shit.

I have plenty of money. I don't have any money issues at all. I always keep a backup fund of $10,000 at minimum and never go below that.



Well, at first, maybe I did think that people weren't taking it seriously. But now, I see that they are. That's reassuring.



It's in a safe location. It was aboard a ship that's been in the shipyard for a couple weeks already. All the fomites on surfaces are dead, and there's no one around. I've been wearing a mask to and from the job site. I have assessed the risks properly and I am taking all appropriate precautions, including spraying touch surfaces with disinfectant, not touching my face, avoiding people and their aerosols, et cetera. There's no point in wearing a mask in an open, well-ventilated space if there isn't anyone around. It's only if you're near people, or in an enclosed space where aerosols may linger in the air, that you should wear a mask outside.

I'm planning on it, actually.

I like Space Engineers, Starmade, KSP, et cetera. I like doing large and complicated builds. I once did a ship in Starmade that had 13 million blocks.

View attachment 1230947

I'm also into digital audio workstation stuff on my desktop rig. I make music. That's why my rig has 128 gigs of RAM. It needs to be able to run Spitfire and Vienna Symphonic Library. I own something like $8 to $10k in virtual instruments.


I'm a little out of practice. I need to get back into it and compose a bit more seriously. The orchestral stuff I do, I like doing layered ostinato sections and odd-meter stuff, almost like math rock. I like to experiment with uncommon sounds, textures, and rhythms. Very often, I sketch pieces simply by singing them a cappella.

One of my tics is singing improv a cappella stuff just, everywhere. Any time I'm alone and I'm not listening to music, I have to make music by singing it. If I'm in the shower, or if I'm alone at work, I'll come up with ideas for my music. Not singing or humming any particular pre-existing song, mind you, but coming up with entirely new compositions.

This is what I mean:





I don't wish to comment on my exact IQ score. Suffice it to say, I am a midwit. Neither a genius nor a dummy. I'm right in that sweet spot where I play second-fiddle to the 130 and 140 IQ people while also being horrified at the mind-numbing stupidity of the average person.



Well, I'm into a little bit of Bakunin, a little of Kropotkin, a little Stirner, and so on, but I'm mainly into Thorstein Veblen.

A lot of people have me confused for an Anarcho-Socialist and Marxist when really, I'm more of a Veblenite/Technocrat.

I don't understand why no one ever debates it when I bring up Thorstein Veblen. His name is like the Fnords from Discordianism.

It's like, people don't see it when you say Thorstein Veblen. His name is invisible. I can say it over and over again, and they still don't see it.

Thorstein Veblen, Thorstein Veblen, Thorstein Veblen.

... and yet, I cannot find a single person willing to discuss the topic at all. It feels almost like a practical joke. Did a person named Thorstein Veblen ever really exist, or did I merely hallucinate it? I'm not sure. I keep naming him, and people keep ignoring it and calling me a Marxist.






I became an anarchist over time due to disillusionment with the state of modern society. I'm not a smashie or a tankie. I take a very dim view of people breaking shit and rioting in the street. I also have an intense dislike of authoritarianism.

I am an American, of course, and since 9/11, I have been subjected to the cavalcade of horrors that is American foreign policy. It's kind of ironic. I love weapons and military technology, but I am a pacifist and generally despise war. From one president to the next, each one promises to end the excesses and warmongering of the last one, but they don't deliver on that promise at all. The Clintoncrats went into Kosovo, and Bush was like "I'm gonna put a stop to that", and then, he started the wars in Iraq and Afghanistan. Obama was like "I'm going to end the Bush-era policies of warmongering and close Gitmo", and not only did he not close Gitmo, he started wars in Libya and Syria.

The CIA straight-up gave a pile of guns, ammo, and TOW missiles to nutcases shouting Takbirs! What the fuck did American troops die in Iraq and Afghanistan for, if we were just gonna give free weapons to another bunch of Salafi lunatics and repeat the same mistake we made when we armed the Mujahideen against the Soviets?



So, basically, American blood was spilled for nothing. We go from fighting terrorists to arming them at the drop of a hat, and no one questions it.

Meanwhile, public services in the US are a complete shambles. Our infrastructure is decaying, people are struggling with medical debt and student debt, and yet, somehow, we have trillions of dollars to blow on these ridiculous wars that serve no purpose.

Saddam didn't have any fucking WMDs.

Afghanistan is a shithole and the Graveyard of Empires and there's no point in being there.

Gaddafi didn't do a fucking thing wrong, he was friends with Sarkozy and supported his campaign only to get backstabbed by that son of a bitch, and the so-called "responsibility to protect" was used as an excuse to invade his country. Oh, gee. I guess if American citizens started rioting and bulldozing government buildings and burning down police stations, the National Guard wouldn't fuck 'em up like they did at Kent State. Gee, I guess that means someone ought to invade us if that happened! Sovereign nations have no right to protect their own sovereignty against rebellion in their own borders. We must bomb them to rubble and deprive people of their government.

Just like we supported rebels in Syria, when people there overwhelmingly supported Bashar al-Assad. The chemical attack in Douma was a complete fabrication, and the OPCW covered up a contradictory report.


You know what I'd like to see as an American? I'd like to see my government quit spending trillions of dollars on military adventurism, and spend a little on revitalizing our goddamn country so we're no longer the laughingstock of the world.

Redevelop and repair the goddamn infrastructure, dammit! They're letting everything fall to fucking ruin!




And that's just to start. I could tell you all sorts of shit about capitalism, conspicuous consumption, planned obsolescence, the throwaway economy, all that, but I'll try and summarize it in just a couple sentences.

Basically, Chinese sweatshop workers make useless fucking plastic trinkets that smell like old car tires, and then they load them on a container ship burning disgusting bunker fuel, and then, that ship comes into port in the US and that shit gets distributed to every Walmart so every dumbass mouth-breathing American can proffer their credit card at the register and go into fucking debt to own more useless plastic junk. This plastic junk is then thrown away in the space of about a year, where it ends up in a landfill, or dismantled by Malaysian children ripping toxic garbage apart with their teeth. All the money goes to China so Xi Jinping can buy more dragon dildos, I don't know.

Basically, I am an anarchist because I realize that I'm living in the prequel to Idiocracy and Wall-E, and I would like to tear this system down before the literal garbage mountains begin to appear.

Yes, yes, I realize that I'm a consoomer. You don't have to pull that "LOL why do you have electronics then?" thing.

I repair all my stuff. I have a soldering iron and bit driver sets. I hardly ever throw anything away.

And I don't buy junk, either. I buy only the best.

Anyway, I've been shifting more towards Classical Liberalism lately because I realized that my anarchist friends were brain-dead morons who didn't give a fuck about the virus and actively shunned me for my very reasonable concerns about it.

Fuck it. I may as well get into investing, make my money, and enjoy myself, and fuck everyone else. Fuck 'em. Altruism is worthless at this point.

I mean, look. They're nominating Joe Biden. Joe Biden. That exceptional kiddie-fiddling, demented fucking freak.


Durr, dey rub mah leg down!

Okay, grandpa.

There is only one thing to do, this coming election. Bring the fucking popcorn. Bring all of it.
We are about to witness levels of salt and butthurt and insanity never-before-seen. This is going to be the stuff of legends. :popcorn:



I wasn't trying to imply that SARS-CoV-2 was related to any of those viruses. Rather, what I was suggesting is that direct immune-suppression (rather than mere avoidance of immune responses) is a trait of some of the most vicious viruses out there. We have to be wary of this thing.

Herpes and Epstein-Barr can avoid immune responses by trying to hide from immune surveillance and going dormant. Ebola and HIV are nasty, but herpes and EBV are fairly common infections that are only really an issue if someone has a weak immune system and they're roused from their dormant state.

SARS-CoV-2 is neurotropic. What if it can hide and go dormant in nerves like herpes? What if it never goes away? We need answers to these questions.



I was discussing the ways this virus avoids immune surveillance with WesternBlotter, a PhD immunologist, and he was seriously creeped the hell out by this thing.

You have no idea how happy I am that a few people on here actually understand the terminology and what I'm getting at with this thing.
bro shut the fuck up, nobody wants to read your fucking treatise "On the Origines of the Corona-Virus and its Many Dastardely and Perniscious Symtomes, Occourences, and Maladies"
 
Mein Gott, you really are a stupid sack of lard, aren't you?

I skimmed. Here's some takeaways

1) When people call you out for being a whiny bitch about a job that pays far better than most folks ever get, whining about working longish hours sometimes is a suboptimal strategy.

2) So you're choosing option "Yes, I'm a liar?" Broke people don't have ten grand in the bank and an investment portfolio, shithead. I don't know if I believe either story, but they can't both be true.
 
I understood on a theoretical level why the Medical/Statistics Kiwis were so keen to make fun of our dear autist.

But when he started milsperging, I truly got it on a visceral level.

I mean holy-shit, what a sperg.

Take this metaphor for his milsperging:

You are minding your own business, eating a slice of toast with butter on it.

Meanwhile Train Doger here is watching a news segment talking about how excessive butter use may have some health effects, and may have a link to heart failure.

So David Clop busts into your house yelling at you not to eat your toast because it has butter on it, because butter causes heart failure.

He insists that after thorough research that he has a much better solution.

Crack a raw egg onto the toast.

After all, he had learned yesterday that eggs also have fat content in them. And fat is where the flavor comes from right?

So, obviously eggs are superior to butter as a toast spread because eggs have fat and are not butter.
 
I understood on a theoretical level why the Medical/Statistics Kiwis were so keen to make fun of our dear autist.

But when he started milsperging, I truly got it on a visceral level.

I mean holy-shit, what a sperg.

Take this metaphor for his milsperging:

You are minding your own business, eating a slice of toast with butter on it.

Meanwhile Train Doger here is watching a news segment talking about how excessive butter use may have some health effects, and may have a link to heart failure.

So David Clop busts into your house yelling at you not to eat your toast because it has butter on it, because butter causes heart failure.

He insists that after thorough research that he has a much better solution.

Crack a raw egg onto the toast.

After all, he had learned yesterday that eggs also have fat content in them. And fat is where the flavor comes from right?

So, obviously eggs are superior to butter as a toast spread because eggs have fat and are not butter.
Epilogue: I beat him into a coma with a baseball bat.
 
*mindless chimp noises and diarrhea for two posts*
Massive waves of spam to obfuscate your stupidity only proves you're an uneducated lardass with serious affluenza and a dishonest streak longer than some political careers.

In short, I'm just gonna mock how you are too retarded to survive on 68k a year, how your whining about menial labor (which is only kept due to nepotism and shitty unions btw since it's obvious you suck at lubricating boats) and being poor doesn't matter because all the shit you whine about is due to your severe alcoholism and tastycake addiction, and that you are trying to argue with an actual virologist when it's obvious you never even got an associates degree is absolute proof of your crippling idiocy and pointlessness on anything you fucking ramble on about.

Lick your doorknobs.
The milsperging is honestly offensive, seeing as he's a chickenhawk and such a fucking pussy he thinks fluorescent lighting is a major hardship.
It's also telling he only wikis and googles things, because he only stopped when he was blown out for being a technophilic imbecile who fails to understand things like battle conditions, logistics, function, and reliability. This was after desperately trying to use a golden BB scenario to mimick Mike Sparks sempai on why the Bradley is a shit vehicle and why his shitty drone design and three different IFV models is better.
 
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My savings were doing okay, but they’re not looking so hot after I bought thousands in prepper supplies.
Those purchases were unnecessary. At most you just needed more groceries and cleaning supplies, buying seven radios is excessive.
I love weapons and military technology, but I am a pacifist and generally despise war.
Then why are you such a Doomer? Don’t Doomers usually salivate over more massive wars and diseases that wipe out entire nations?
Basically, I am an anarchist because I realize that I'm living in the prequel to Idiocracy and Wall-E, and I would like to tear this system down before the literal garbage mountains begin to appear.
Okay, this sounds exactly like something that Moviebob would say. Also, tearing down a system (whatever that system is) isn’t permanent. People like having order, and anarchy is the opposite of that. Aside from that, using Wall-E and Idiocracy (both fictional) to discuss real world politics is one of the laziest things. You know who else likes to use movie references to discuss politics? Moviebob.
 
1) When people call you out for being a whiny bitch about a job that pays far better than most folks ever get, whining about working longish hours sometimes is a suboptimal strategy.

2) So you're choosing option "Yes, I'm a liar?" Broke people don't have ten grand in the bank and an investment portfolio, shithead. I don't know if I believe either story, but they can't both be true.

Oh, come on. I never said I was broke.

I understood on a theoretical level why the Medical/Statistics Kiwis were so keen to make fun of our dear autist.

But when he started milsperging, I truly got it on a visceral level.

I mean holy-shit, what a sperg.

Take this metaphor for his milsperging:

You are minding your own business, eating a slice of toast with butter on it.

Meanwhile Train Doger here is watching a news segment talking about how excessive butter use may have some health effects, and may have a link to heart failure.

So David Clop busts into your house yelling at you not to eat your toast because it has butter on it, because butter causes heart failure.

He insists that after thorough research that he has a much better solution.

Crack a raw egg onto the toast.

After all, he had learned yesterday that eggs also have fat content in them. And fat is where the flavor comes from right?

So, obviously eggs are superior to butter as a toast spread because eggs have fat and are not butter.

I am personally of the opinion that military scientists should be deferring to the grunts and boots on the ground more often, to be honest.

If I worked at DARPA, for instance, one of the first things I would do is establish a liaison unit to try and bring in more people with actual front-line experience for their input.

You ever notice something about all this Land Warrior bullshit? The stuff is heavy. The gear is more load on a soldier's knees. They just pile it on. Over a hundred pounds of junk, grinding down young men's cartilage to dust.


Substantial research has assessed the risk factors for injury in the military [1, 3, 4, 6, 10, 12, 14]; however, results are often contradictory and focus on individual factors, when in reality, a large number are inextricably linked. Load carriage and training are commonly cited as causative factors towards musculoskeletal injury within military forces, particularly army [1, 3, 4, 6, 810, 1519]; however, the effect that footwear can have on injuries has received minimal attention in previous reviews of military injuries despite the research completed in this area [3, 7, 9, 2022]. Footwear can have a significant effect on gait and performance of tasks, which in turn can lead to injury. The aim of this review is twofold; first, to review the current literature regarding injury causes in the military and second, to demonstrate the influence footwear can have on injury incidence. This review will investigate the prevalence and risk factors for musculoskeletal injury in army populations, the effects of load carriage, training and footwear and finally, schemes for injury prevention and their effectiveness.

Sooner or later, we're gonna need exoskeletons for our troops just so they can walk while carrying all this bullshit on their bodies. Without, y'know, developing long-term, chronic injuries.

Or, maybe they could find some way to lighten the infantryman's fucking load, because this shit is ridiculous.

LPqQ22LYflA4Z-1UY9LMAQQDK5RnXjdw7x8Fj0OAHiM.png
combat-load-presentation1-22-638.jpg
Over a hundred pounds of shit, grinding away healthy young men's knees. Fucking ridiculous!
 
What's ridiculous is you think you're qualified to talk about infantry combat loads when you couldn't even lift an M2 receiver.

Shut the fuck up and stay in your lane-- Skyrim, MLP, and getting diddled by your Dad.
 
Dammit, I hit the character limit. Okay, Part 2.



Severe host response was something that was noted in SARS, as well. COVID-19 and SARS pathology are very, very similar, as best as I can tell. The key difference with COVID-19 is that SARS-CoV-2 has furin cleavage sites on its spike glycoproteins that enable highly efficient fusion with human cells. This makes it spread a lot faster than SARS-CoV ever could, and it also might enable it to infect cell lines that SARS-CoV can't, like this immunosuppressive, T-cell-destroying effect that we're seeing.

More research is needed. More data is desperately needed on the potential vascular and neurological complications, as well as this immune-system-suppressing effect.



Hey, I’m not into CP. That’s fucking disgusting. Drawings are just fucking drawings. Some sicko abusing a child and filming it is a completely different story. That’s totally unacceptable.

I have a brokerage account where I sock away money, and my investments have actually consistently gained value. I made a modest amount off that. Like $1400 last year and $700 this one. My savings were doing okay, but they’re not looking so hot after I bought thousands in prepper supplies.

Also, the calculations for how much I drink are completely wrong. I don't buy $140 in liquor every month. I buy $140 in liquor like every five months. I don't do 16 fucking shots a day. I can go weeks without having a drop of liquor, and when I do drink, it's usually like between five to ten shots worth. I'll binge for one day, and then go another few weeks without anything. Most of the time, I have like one or two beers a day is all.

Most of the cash that I do blow goes into big-ticket, durable items. I'm a mechanical keyboard nut and I have a fondness for audio gear and cameras and electronic shit.

I have plenty of money. I don't have any money issues at all. I always keep a backup fund of $10,000 at minimum and never go below that.



Well, at first, maybe I did think that people weren't taking it seriously. But now, I see that they are. That's reassuring.



It's in a safe location. It was aboard a ship that's been in the shipyard for a couple weeks already. All the fomites on surfaces are dead, and there's no one around. I've been wearing a mask to and from the job site. I have assessed the risks properly and I am taking all appropriate precautions, including spraying touch surfaces with disinfectant, not touching my face, avoiding people and their aerosols, et cetera. There's no point in wearing a mask in an open, well-ventilated space if there isn't anyone around. It's only if you're near people, or in an enclosed space where aerosols may linger in the air, that you should wear a mask outside.



I'm planning on it, actually.



I like Space Engineers, Starmade, KSP, et cetera. I like doing large and complicated builds. I once did a ship in Starmade that had 13 million blocks.

View attachment 1230947

I'm also into digital audio workstation stuff on my desktop rig. I make music. That's why my rig has 128 gigs of RAM. It needs to be able to run Spitfire and Vienna Symphonic Library. I own something like $8 to $10k in virtual instruments.


I'm a little out of practice. I need to get back into it and compose a bit more seriously. The orchestral stuff I do, I like doing layered ostinato sections and odd-meter stuff, almost like math rock. I like to experiment with uncommon sounds, textures, and rhythms. Very often, I sketch pieces simply by singing them a cappella.

One of my tics is singing improv a cappella stuff just, everywhere. Any time I'm alone and I'm not listening to music, I have to make music by singing it. If I'm in the shower, or if I'm alone at work, I'll come up with ideas for my music. Not singing or humming any particular pre-existing song, mind you, but coming up with entirely new compositions.

This is what I mean:





I don't wish to comment on my exact IQ score. Suffice it to say, I am a midwit. Neither a genius nor a dummy. I'm right in that sweet spot where I play second-fiddle to the 130 and 140 IQ people while also being horrified at the mind-numbing stupidity of the average person.



Well, I'm into a little bit of Bakunin, a little of Kropotkin, a little Stirner, and so on, but I'm mainly into Thorstein Veblen.

A lot of people have me confused for an Anarcho-Socialist and Marxist when really, I'm more of a Veblenite/Technocrat.

I don't understand why no one ever debates it when I bring up Thorstein Veblen. His name is like the Fnords from Discordianism.

It's like, people don't see it when you say Thorstein Veblen. His name is invisible. I can say it over and over again, and they still don't see it.

Thorstein Veblen, Thorstein Veblen, Thorstein Veblen.

... and yet, I cannot find a single person willing to discuss the topic at all. It feels almost like a practical joke. Did a person named Thorstein Veblen ever really exist, or did I merely hallucinate it? I'm not sure. I keep naming him, and people keep ignoring it and calling me a Marxist.





I became an anarchist over time due to disillusionment with the state of modern society. I'm not a smashie or a tankie. I take a very dim view of people breaking shit and rioting in the street. I also have an intense dislike of authoritarianism.

I am an American, of course, and since 9/11, I have been subjected to the cavalcade of horrors that is American foreign policy. It's kind of ironic. I love weapons and military technology, but I am a pacifist and generally despise war. From one president to the next, each one promises to end the excesses and warmongering of the last one, but they don't deliver on that promise at all. The Clintoncrats went into Kosovo, and Bush was like "I'm gonna put a stop to that", and then, he started the wars in Iraq and Afghanistan. Obama was like "I'm going to end the Bush-era policies of warmongering and close Gitmo", and not only did he not close Gitmo, he started wars in Libya and Syria.

The CIA straight-up gave a pile of guns, ammo, and TOW missiles to nutcases shouting Takbirs! What the fuck did American troops die in Iraq and Afghanistan for, if we were just gonna give free weapons to another bunch of Salafi lunatics and repeat the same mistake we made when we armed the Mujahideen against the Soviets?



So, basically, American blood was spilled for nothing. We go from fighting terrorists and insurgents to arming them at the drop of a hat, and no one questions it.

Meanwhile, public services in the US are a complete shambles. Our infrastructure is decaying, people are struggling with medical debt and student debt, and yet, somehow, we have trillions of dollars to blow on these ridiculous wars that serve no purpose.

Saddam didn't have any fucking WMDs.

Afghanistan is a shithole and the Graveyard of Empires and there's no point in being there.

Gaddafi didn't do a fucking thing wrong, he was friends with Sarkozy and supported his campaign only to get backstabbed by that son of a bitch, and the so-called "responsibility to protect" was used as an excuse to invade his country. Oh, gee. I guess if American citizens started rioting and bulldozing government buildings and burning down police stations, the National Guard wouldn't fuck 'em up like they did at Kent State. Gee, I guess that means someone ought to invade us if that happened! Sovereign nations have no right to protect their own sovereignty against rebellion in their own borders. We must bomb them to rubble and deprive people of their government.

Just like we supported rebels in Syria, when people there overwhelmingly supported Bashar al-Assad. The chemical attack in Douma was a complete fabrication, and the OPCW covered up a contradictory report.


You know what I'd like to see as an American? I'd like to see my government quit spending trillions of dollars on military adventurism, and spend a little on revitalizing our goddamn country so we're no longer the laughingstock of the world.

Redevelop and repair the goddamn infrastructure, dammit! They're letting everything fall to fucking ruin!




And that's just to start. I could tell you all sorts of shit about capitalism, conspicuous consumption, planned obsolescence, the throwaway economy, all that, but I'll try and summarize it in just a couple sentences.

Basically, Chinese sweatshop workers make useless fucking plastic trinkets that smell like old car tires, and then they load them on a container ship burning disgusting bunker fuel, and then, that ship comes into port in the US and that shit gets distributed to every Walmart so every dumbass mouth-breathing American can proffer their credit card at the register and go into fucking debt to own more useless plastic junk. This plastic junk is then thrown away in the space of about a year, where it ends up in a landfill, or dismantled by Malaysian children ripping toxic garbage apart with their teeth. All the money goes to China so Xi Jinping can buy more dragon dildos, I don't know.

Basically, I am an anarchist because I realize that I'm living in the prequel to Idiocracy and Wall-E, and I would like to tear this system down before the literal garbage mountains begin to appear.

Yes, yes, I realize that I'm a consoomer. You don't have to pull that "LOL why do you have electronics then?" thing.

I repair all my stuff. I have a soldering iron and bit driver sets. I hardly ever throw anything away.

And I don't buy junk, either. I buy only the best.

Anyway, I've been shifting more towards Classical Liberalism lately because I realized that my anarchist friends were brain-dead morons who didn't give a fuck about the virus and actively shunned me for my very reasonable concerns about it.

Fuck it. I may as well get into investing, make my money, and enjoy myself, and fuck everyone else. Fuck 'em. Altruism is worthless at this point.

I mean, look. They're nominating Joe Biden. Joe Biden. That exceptional kiddie-fiddling, demented fucking freak.


Durr, dey rub mah leg down!

Okay, grandpa.

There is only one thing to do, this coming election. Bring the fucking popcorn. Bring all of it.
We are about to witness levels of salt and butthurt and insanity never-before-seen. This is going to be the stuff of legends. :popcorn:



I wasn't trying to imply that SARS-CoV-2 was related to any of those viruses. Rather, what I was suggesting is that direct immune-suppression (rather than mere avoidance of immune responses) is a trait of some of the most vicious viruses out there. We have to be wary of this thing.

Herpes and Epstein-Barr can avoid immune responses by trying to hide from immune surveillance and going dormant. Ebola and HIV are nasty, but herpes and EBV are fairly common infections that are only really an issue if someone has a weak immune system and they're roused from their dormant state.

SARS-CoV-2 is neurotropic. What if it can hide and go dormant in nerves like herpes? What if it never goes away? We need answers to these questions.



I was discussing the ways this virus avoids immune surveillance with WesternBlotter, a PhD immunologist, and he was seriously creeped the hell out by this thing.

You have no idea how happy I am that a few people on here actually understand the terminology and what I'm getting at with this thing.
yea but the coronavirus is clearly less deadly than the flu, more people die from the flu every year.
 
Yeah, uh.. 75-100lbs of equipment is legitimately not that heavy for anyone in any reasonable amount of shape even in a civilian setting. In a military setting where exercise is routine and mandatory because eating 15 bags of Chex Mix isn't an option, that weight is barely even worth mentioning. Unlike the military where they only have to carry that weight for brief periods of time, most civilians carry around an extra 100-200lbs of weight "on their knees" all day, every day, for potentially their entire lives because they're fat.
 
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