There was a mountain of evidence against Knox. Copy and pasted from another thread:
It's a matter of stacking the anomalies up and asking your self "What are the chances these are just coincidences?" I'll list some of them below and, in the interest of fairness, offer the Foxy Knoxy explanation for each one.
Rafaelle called the police (after the presence of the postal police prompted him to make the call) and the told the operator "nothing has been stolen" before having knowledge of whether anything had been stolen or even if the intruder had been in the locked bedroom.
He was speaking in general terms. It looked like nothing had been stolen.
Rafaelle pre-empted what the forensic testing on his knife would reveal and said that Amanda had cut Meredith the day before in a vegetable chopping accident. (Knoxy on the handle, Meredith on the blade)
Being in custody made Raf delirious so he isn't to be believed and the DNA evidence is insufficient.
The police found it odd that an attempt had been made to scrub the passage clean.
Amanda shuffled naked on a bath mat after showering because she didn't want to get the floor wet.
Rudy's footprints go straight from the murder room, down the passage and out the door. There is no evidence that he turned to lock the door.
It is physically possible to hover on one foot and twist your body round to lock a door behind you, so that's what he must've done.
A witness saw Raf and Amanda near the cottage at the time of the murder.
He was put up to it by corrupt prosecutors.
Another witness saw them.
He was mistaken.
A shop owner reported Amanda waiting outside his shop at 7am before buying bottles of bleach.
Another girl who looked just like Amanda also urgently needed bleach that morning.
Raf and Amanda's phones were turned off just after the estimated time of the murder and came back on early in the morning, oh around the time that other girl was buying bleach.
Coincidence.
Amanda and Raf said they had slept through the night but computer forensics revealed activity on the device at that time. They lied.
They misremembered,
Shards of glass from the broken window was lying on top of the items in the room that had supposedly been ransacked.
No they weren't / corrupt police
Raf's bloody footprint found on bathmat.
Rudy had the same size feet as Raf. Oh, and he took his shoes off after he killed Meredith and then put them back on.
Amanda's lamp (her only light source) was found under Meredith's bed, which led police to think it had been used during the clean-up.
Meredith had been borrowing it.
Amanda and Meredith's mixed blood was found in the bathroom.
Contamination.
Amanda and Meredith's mixed DNA found in the break in room (Filomena's room).
Contamination.
Raf's DNA on Meredith's bra clasp.
Contamination.
Raf's classmates at college called him 'knife boy' because he was known to always carry a knife.
This proves nothing.
All three suspects changed their stories multiple times. The version that Amanda committed to paper falsely accused someone as well as placed herself at the crimescene.
She was was coerced by corrupt police.
The police and independent translator all deny that the interview lasted longer than 2 hours and that she was hit by officers. In fact, it was Amanda who requested to be there because she didn't want to part company with Raf who was being questioned first.
They're all corrupt liars.
The postal police who were on the scene originally felt Amanda and Raf were acting very strangely.
They're corrupt liars as well.
Amanda delayed the discovery of the body by telling the postal police Meredith always locked her door. The other two roommates confirmed the opposite to be true.
The police are lying again.
Amanda knew details of the crime scene which she couldn't have known.
She heard police mention them.
The postal police arrived at the cottage to find Amanda and Raf standing with a mop and cleaning equipment, which led them to think they were engaged in a clean-up job. Fancy that?
There had been a leak at Raf's apartment and they had just nipped over to the cottage to collect the cleaning equipment for the real clean-up job.
The acquitting court maintained that Meredith was killed by multiple persons despite only being able to secure a conviction for one.
It's not Amanda's job to find the other killers, is it?
Rudy Guede's final version events places Amanda and Raf at the scene.
He's lying.
Amanda had scratch marks on her neck and ear.
Hickies and an earring accident.
In the early part of the investigation Amanda and Raf couldn't remember whether or not they had left the house the night before.
"I can't even remember what I did 10 minutes ago lol"
And for what it's worth...
Amanda has giggled her way through interviews and cartwheeled through interrogation rooms. She constantly says and does inappropriate things, refuses to talk about Meredith and has been caught blatantly lying on multiple occassions. For example, telling Joe Rogan she called the police. The Behaviour Panel also had a field day with her.
She's zany. She's whacky. She's autistic. You can't use normal behaviour as a yardstick to understand Amanda Knox.
If Amanda is innocent, then the world truly conspired against her that day. Corrupt officials out to get her at every turn, multiple cases of mistaken identity, an unfortunate vegetable chopping accident, an untimely towel shuffle, a pesky plumbing problem, multiple incidences of calamitous contamination, annoying bouts of amnesia, an early morning computer sesh, an improbable home intrusion and a phone call fuck up.