Big dicks build micro ITX.
Autism for a moment: my days building full tower ATX builds are well behind me. For the last couple builds I have gone with smaller form factors. It has been a lot of fun and forced me to get creative. Feels a lot like when I was a kid building some of my first systems. I want smaller and quieter.
This time I finally got the courage to try micro ITX. It has been very rewarding, but with this new generation of GPUs I decided to hold off on completing the core aspects of the system. And unfortunately early-gen cards tend to run large. No rush though; I have dual 1060s at the moment and I really can't say enough good things about that chipset. It is well-balanced and runs efficiently.