After the Enclave's California Branch fell, a struggle resulted in a power vacuum lasting almost a decade. With brothers divided on either staying as genetic purists or becoming integrators, the concept of a successor to the United States sets back the Enclave for an eternity. The conflict is temporarily halted, with Enclave Chicago's intel on Mississippi River Kingdoms increasing their prominence. Although having a predominant grasp of Chicago, the phantom-like representation of Enclave Chicago worries the ghosts of another massacre of their people. Your team, The Bloodhound Regiment, was sent miles away from Chicago to get in contact with an agent who has recently been MIA. During this process, an artillery dispatch strikes your Vertibird. As soon as the crash ends, your team is ambushed by wildmen, becoming targets in a foreign land full of foreign dwellers.
Fallout: The Muddles From Ole'Miss occurred throughout multiple states 2255, from Minnesota to Louisiana. The player's initial mission was to find a secret Enclave Agent in St. Paul of his current reports of the cities' growth. Over time, depending on the player's choices, they'll discover that the agent was murdered. In the style of New Vegas, they'll determine whether they side with their blood-connect Enclave or split their ways to support the new civilizations of the muddy wasteland. While war never changes, but nature, nature always changes. The post-nuclear world of the Mississippi River will have the player experience snowstorms, hurricanes, floods, tornados, radiation storms, and new world plagues that even the best of the Enclave's doctors make them scratch their heads. Will your character survive these brutal conditions or perish on their return mission?