On my last run, I killed all the enemies in Salida del Sol South and got most of the loot only to find that the 6 of something playing card had disappeared. Whether it got physicsed somewhere or just vanished because fuck you I can't say. I just know I had to reload and start over. Like I said, always something with that area. And the distorted bell ringing. It's not so bad when you first get there but after a few minutes it's like UUUuuuUUUGHHHhhhH.
The very first time I played DM, Christine opened the door to the vault for me. Every other time she never did it and I had to open the door myself. I distinctly remembered her walking to the microphone and saying "begin again" all these years but I was just starting to think I imagined it. On my last run she actually did it. I still don't know what I did differently.