I'm a few hours in and I'm starting to hate the innkeeper. He was irritating enough when they introduced him because he is so obviously a man, but they keep forcing him in my face and I do not appreciate it. Takes me out of the game way more than the oddly diverse cast. Even my girlfriend, who is pretty apolitical, noticed it.
Thing is, Cyberpunk 2077, which is one of my favorite games of the last decade also has a tranny in it. However, Claire is a character that makes a lot more sense in the setting and is not shoved in your face all the time the way Sirona is. If you don’t do the racing quests and/or talk too her, you wouldn't even find out. I didn't notice until I saw the trans flag on the back of her car.
Getting back to Sirona, I hear that he's gonna be less important later in the game, and I can't wait.