Another good option would be Chloe Zhao.
The Chris Chan Saga would have to be an arthouse epic with blockbuster elements and an ensemble cast.
It would still have tons of comedy, given the subject matter, and even some horror, but the films would be an arthouse period drama spanning generations.
Chloe Zhao has proven that she can make a great blend between arthouse and blockbuster elements with comic relief, with Eternals being a really amazing if divisive film.
And if 12 hours per film is too long, it would have to be six hours per film, with an intermission in the 3-hour mark and each film being released in a TV series format with one hour per episode and six episodes per film, where one season would cover one film.
Benedict Cumberbatch as the state psychiatrist would be good.
The film's score would have to be done by Hans Zimmer.