Looking back, RE3 remake legit added a plothole to the rest of the series. That is being Nicholai's survival. In the original, depending on your choices, Nicholai could either perish or escape the city in a stolen helicopter (leading to Jill and Carlos being rescued by Barry of all people). The main entries dont mention him again so it is kept vague which version is canon, however, iirc, a document in a spin off (survivor, I think) is written by Nicholai detailing the events of his escape, so he kind of canonically gets away with it.
With all of this said, the remake has Nicholai being left to die at the nuking of the city, with Jill, almost out of character, just spitefully letting him die despite him claiming to have precious info on who his real boss is (highly implied to be Wesker).
So the remake actually disrupted canon because Nicholai is able to escape and I recall seeing some many fans eating up the copium saying he took a different helicopter to escape. What an awful game.