I actually quite like the Vulcan-human dynamic (second to the Klingon-human dynamic) since unexpressed pleasure seems to be a motive behind Vulcan psychology. The neat thing about Sarek's 'dementia' was that it was portrayed as him just being consumed by a psychosomatic eruption of what he had buried deep inside, his pleasures and his pains, until he's just writhing in the final space acid trip that Vulcans consider to be the same as Alzheimer's. It's a very rich thing to imagine.
Klingons get to be this weird aggro-tistic thing that feels fleshed out and interesting in spite of muh warrior culture. Characters like Worf who are autists to the extreme, Christopher Plummer's guy in The Undiscovered Country, the weird horny Klingon sisters, Gowron, they've got a real deep vein of interesting weirdos united by their love of knives, hate for nerds, and insistence on blood feuds. It's a great fictional culture, and their interactions and constant judging of humans is usually played pretty interestingly. The actors who don the rubber foreheads seem to get it. But humans kind of already know what to expect from the Ferengi, after all we have our own goblins, and we've got crafty scheming bastards just like Romulans also. They always seem more cartoonish than the Ferengi just because they're paranoid and villainous. I haven't seen much of the Cardassians outside of some Gul Dukat memes and one or two episodes they show up in, so I'm pretty excited to get into DS9 and see the kind of shit they get up to.