I find the following specific items problematic:
Adventure Booklet:
P 16, "Degenerate
[Reroll if the Town has the keyword ‘Law’ or the trait ‘Law-Abiding’]
The womenfolk here aren’t safe to walk the streets alone. Any Female Hero that visits a Town Location without a Male Hero is at risk of being assaulted. If unaccompanied, make a Strength 4+ test. If failed, that Female Hero takes
Hits (1 Damage each) and rolls on the Injury Chart if she suffers more than 3 Wounds."
This entire encounter is as needless and offensive. The *only* purpose it serves is to remind people that, even in a board game, they're subject to sexual assault.
P 18, "Fancy House
Every night you stay in this Town, each Hero rolls a D8. On a 1 or 2, a Male Hero loses $50 and gains the keyword ‘Rash’. While you have ‘Rash’, your Hero is -25% Health (rounded up). This may be removed at the Doc’s Office with a Surgery attempt. On a roll of 8, that Hero instead loses $100 and may remove one Madness. Female Heroes who roll a 7 or 8 may gain $100 if they choose to."
The game doesn't need mechanics for brothels, especially ones that force characters into sexual encounters.
I haven't yet looked at the encounters book, and wasn't planning on it.
I'm not particularly familiar with Native cultures, but the whole Kemosabe/Paleface status seems pretty tone deaf, too.