No, but it's also a medieval society where everyone has a russian accent so I think they are too far removed from that location. Lorath is the wet-behind-the-ears kid who was standing next to Tyrael in D3 Reaper of Souls adventure mode, so to see him aged up & jaded is interesting, because he looked up to Tyrael as his senpai and wanted to date Kadala the blood shard gambling vendor.
Inarius is alive and you speak to him directly, which is great, but I don't understand how access to Heaven or Hell is locked for them. Tyrael and Malphael seemed to have easy access, and Imperious visits Pandemonium easily. They haven't really explained how Sanctuary works as far as being locked off/connected to other realms. The Prime Evils needed soulstones to stay, but otherwise they could visit briefly.
All the Prime Evils were killed and condensed into Zoltan Kulle's black soulstone, and then Malthael was using it, then destroyed it to fight the nephalem protagonist in 3(presumably because a powered up being that was half demon, half angel was too much for him, and still was), so all seven Evils, Prime and Lesser are presumably free to reconstitute in Hell. Diablo will likely be a endgame boss past Lillth, in the same way in POE you go after the campaign to the map conquerors in the Atlas and post-game fight Sirus for a second campaign ending.