Interesting. If you pay really close attention in the new trailer, it looks like there are RPG mechanics like San Andreas again. It's hinted at. Notice how Jason and Lucia have different physiques throughout the trailer. In some parts, they have noodle-arms, and in others, huge definition. Look at Lucia's back when she's wearing the dress, and then, that shot inside the plane's landing gear where she's morphed into a Scary Varbie Latina Goblina. Also, we see Jason lifting.
I'm betting they brought back CJ-style "go to the gym for stat progression" mechanics. Of course, I could be full of shit, and this is just how they appear at linear points throughout the game, but that would be disappointment. What's the point of realtime cutscenes if you can't goof around by having a character look ridiculous in them?