In 1998, a Noh masked armed man leads a group of assassins to invade the house of Mr. White in order to kill him as revenge for the latter killing his family. The masked man kills Mr. White's wife in front of him, and, injures him. However, before he can kill Mr. White, young Madeliene Swann uses her father's pistol to shoot the masked man, revealing his disfigured face.
The masked man pursues the girl to a frozen lake, into which Swann jumps and the man saves her instead of killing her. He escapes with his assassins, and, Swann returns to her father. Together ,they mourn on the mother's death.
23 years later, in 2021, James Bond leads his retirement life with Swann at
Jamaica yet he is haunted by his past memories from MI6. At a nightclub, he reunites with Felix Leiter who asks for Bond's assistance in a new mission; find scientist Valdo Obruchev who has gone missing. Bond refuses, and, encounters a woman who leads him back to his household.
There, she reveals herself to be the new 00 agent Nomi and she offers him to return. Bond refuses again yet states he would think on it. A day later, Bond and Swann are having a romantic vacation at
Matera, in which Bond asks her to marry him to which she agrees. However, they are then attacked by a group of assassins whom Bond defeats using his
Aston Martin DB5.
Bond decides to return to London, but not before Swann tries convincing him she would not think of betraying him. In London, Bond returns to the MI6 and M, Tanner and Q tell him that the assassins he encountered in Italy were led by a military mercenary named Primo. Afterwards, Bond decides to interrogate Ernst Stavro Blofeld, who is imprisoned. Before he can enter, he sees Swann and confronts her.
While interrogating Blofeld, Bond learns that Swann keeps a secret from him which Blofeld uses to taunt Bond, saying it would destroy him. Bond confronts Swann and pleads her to return to Jamaica. She refuses, enraging Bond yet she decides to reveal her secret.
She tells him again of the attempted assassination against her father at the hands of SPECTRE and reveals that her father once killed a family of a man named Safin, who seeks revenge for his family's death. After failing to kill White, he aims himself to kill her. After MI6 fails to find any information of Safin, Bond is sent to a prom charity event located at
Havana, where he meets Felix's CIA protege Paloma who guides him through the prom event and tells the CIA has recently learnt that Obruchev was abducted by Primo, who is connected to Lyutisifer Safin, which the CIA considers him a most-wanted terrorist.
The two are attacked by assassins again, and together with Nomi's assistance they defeat them. Nomi tells them that her mission was to rescue Obruchev from Primo and his men in his lab at Europe, but she was attacked. Meanwhile, at the safe house in London, Swann meets Safin who threatens to kill Bond if she won't come with him. Broken by her secret and Safin's manipulation on her, Swann tearfully agrees. Bond returns to the safe house, and finds Swann missing. Enraged, he soon learns it was Safin taking her.
Bond once again interrogates Blofeld on Safin, which Blofeld seems to hate and tells that Safin was originally an assassin of SPECTRE until he defected. As punishment for his defection, Safin was facially disfigured by a nerve agent. Blofeld then taunts Bond with Swann and Bond beats him. Returning to MI6's intel office, Bond, M, Nomi, Tanner, Q and Nomi are learning from the CIA that Safin uses Obruchev's nanobot bioweapon to turn key military people and world leaders to become his weapons.
Bond recalls Paloma's words that Safin is said to be located at the North Atlantic. Flying an armed advanced seaplane, Nomi and Bond find an island with submarine pen in the North Atlantic. At Safin's island, they are attacked by an army of guards and assassins which they later defeat. Following Safin's Noh mask on the telescreens, Bond and Nomi find a large science complex and together they learn he uses Obruchev's technology to wage war.
Nomi is attacked by Primo and his army, while Bond follows Safin's mask telescreens until he finally reaches to Safin in his lair. Safin explains his motives and later reveals his ultimate plan is to create oblivion for mankind by killing state enemies across the globe and turn the world leaders into his own weapons in order to replace the United Nations' role on world domination. Safin takes Bond with him to a tour at his base, leading him to the exotic poison gardens he has, in which he kills several scientists for failing him. Bond later attacks his guards, and Safin escapes but not before he activates Obruchev's system to begin his plan.
Bond later finds Swann freed and they reunite with Nomi to destroy Safin's island base, hoping to stop his plan. M tells them to retreat while Bond refuses. Fighting their way into Safin's lab facility, they plant bombs which they detonate and manage to destroy most of Obruchev's weapon. The trio later escape soon as Safin's base is completely destroyed and learn they are in Norway.
Bond and Swann follow Safin's helicopter while Nomi, with her Aston Martin Valhalla, backs them soon as Safin's army attacks them. After the chase, they use the seaplane to follow Safin. Bond and Nomi then find a little girl named Matilda with Swann at the plane, which Swann tells them it is a child Safin grew as his clone of Swann after a failing attempt to create more clones for his legacy.
They reach to Scotland, in which Safin crashes their plane into
Cairngorms National Park. There, Safin lands with his army to find and kill Bond and the others, leading to a lengthy destructive battle. During the battle, Safin tells Bond that his plan is already happening and that several countries already opened in a war. After a gunfight, Bond surprises Safin and the two fight. Primo is killed by Nomi and Swann. Safin then taunts Bond who overpowers the former and defeats him. At the helicopter, Bond disarms Obruchev's technology with Safin's trigger. Safin later tries to kill Matilda, but Swann shoots him and he is taken into custody for his crimes.
In the aftermath, Blofeld is freed by a SPECTRE agent in his prison facility. Safin asks for freedom, yet Blofeld leaves him. Bond and the others are welcomed by the MI6 as heroes. Swann decides to join the MI6 and raise Matilda as her and Bond's daughter.
