Science One in four who had Pfizer Covid jabs experienced unintended immune response - lol

More than a quarter of people injected with mRNA Covid jabs suffered an unintended immune response created by a glitch in the way the vaccine was read by the body, a study has found.

No adverse effects were created by the error, data show, but Cambridge scientists found such vaccines were not perfect and sometimes led to nonsense proteins being made instead of the desired Covid “spike”, which mimics infection and leads to antibody production.

mRNA jabs, such as the ones created by Moderna and Pfizer, use a string of genetic material to tell the body to create a specific protein that safely imitates an infection.

Research in the field, spanning decades, had been slow work. It often stalled because RNA itself is often attacked by the body as a foreign invader.

But in 2023, the Nobel Prize for Medicine went to the pair of scientists who had spent years working to fix the problem. It was done by taking one of the RNA bases, uridine, and swapping in a very similar synthetic alternative.

This breakthrough allowed scientists to create proteins in the body without the immune system attacking the jab.

It allows for quick and precise vaccines that are highly effective and was the backbone of the Covid vaccine response.

Not a perfect fit​

It was thought the minor tweak to uridine caused no problems in cells, but a team of researchers at the University of Cambridge’s Medical Research Council (MRC) Toxicology Unit have now found when this partially synthetic code is read, the protein-making machine in the body sometimes struggles with the uridine analogues.

Because it is not a perfect fit for what is expected, there can be a momentary pause which causes the process to stutter and a letter in the code can get skipped, much like a bike slipping a gear.

This process, called frameshifting, throws out the way the code is interpreted as it relies on groups of three bases, known as codons, being read in the right order.

This issue, caused by the jab’s code, throws the process completely out of sync and the entire subsequent code becomes garbled.

In the case of the Covid jabs, the end result is a nonsensical and harmless protein, the team found, which the body attacks and leads to an immune system flare-up. The new study, published in Nature, found this occurred in around 25-30 per cent of people.

Rogue protein fear​

The vaccine is read well enough to create the strong protection against the coronavirus, the scientists say, but the frameshifting issue creates what was, until now, an unknown off-target effect.

The code relating to the Covid vaccines was harmless and no issues were created. However the team say that subsequent mRNA vaccines used for other diseases or infections could, in theory, lead to viable proteins being created that are active in the body.

In this scenario not only is the vaccine not making the right protein, it could lead to a rogue protein being produced.

There is no evidence of this occurring in the Covid jabs, the authors stress, and they say any trials on other mRNA therapeutics would detect any such problems in early stages.

Dr James Thaventhiran, senior author of the report, said: “Research has shown beyond doubt that mRNA vaccination against COVID-19 is safe. Billions of doses of the Moderna and Pfizer mRNA vaccines have been safely delivered, saving lives worldwide.”

The authors also found that there is an easy way to eradicate the frameshifting events which relies on changing the code of the mRNA drug to minimise the use of the problematic pseudo-uridine.

Replacing it with a natural base that when read as a trio still makes the correct amino acid is enough to stop the unwanted skips and therefore improve safety without sacrificing efficacy.

These findings were shared with medicines regulator MHRA around a year ago, the scientists say, and updated vaccines that use the improved form of mRNA are in the works for cancer jabs, and other therapeutics.

‘Revolutionary technology’​

“This technology is amazing and it’s going to be revolutionary as a new medicine platform for all sorts of things, but we’ve just made it a whole lot safer going forward,” Professor Anne Willis, co-senior study author and director of the MRC Toxicology Unit told reporters.

“Ribosomes are somehow sensing the modified RNAs, but the Covid vaccines are very, very safe and very, very efficacious.

“But there are decoding issues with this technology that can cause stalling and frameshifting and we can get cellular immunity to these peptides after vaccination.”

However, she adds it is very exciting that there is a way to fix the issue, which “massively de-risks this platform going forward”.

https://news.yahoo.com/more-one-four-had-mrna-171724613.html (Archive)

 

[SouthernBitchBob]

What's this the experimental shot that hilariously purported to prevent the common cold had horrible side effects?

No way. How could we have known.

 

[Qtinterval]

I feel you on the Anthrax jab. I took the 90's prototype and wished I was dead for like 2 months. Same with influenza-zero and chickenpox-zero tests.

When they were like "The SCIENCE is good! It'll be safe!" I was in the "fuck you, you said that about Anthrax and Influenza and Chickenpox vaccines, you faggots."

Just think, you'll get the 'government made me sick' treatment that the VA does.

You'll see them admit to it when 80% or more of the people with side effects die off.

That's the fucked up thing about it. I don't remember having any reactions when I first got it. If I did they weren't bad enough to even register.

I've been dealing with the VA trying to get it diagnosed, instead of diagnosing they three pills tried to say it was a somatic disorder (all I my head), even after a community care neurologist did a skin biopsy to diagnose small fiber neuropathy that was caused by an unidentified autoimmune disorder. Probably the whole reason it's taken 8 years to get start identifying it. Decided to get smart and basically cut them out and paid out of locket/Medicare for the immunologist. Will loop then in when/if I progress to bot being able to wipe my ass and make them pay for all the shit that's going to be needed....as well as keeping myself alive just to ensure they keep paying it. Woukd be even funnier if for some reason I have to start taking IVIG treatments (hasn't really been found to help with inclusion body myositis, but could help with the small fiber) and that suits like 10k a treatment (need multiple treatments over about 5 days every month).

 

[SouthernBitchBob]

And which cells were sacrificed at the altar of printing spike proteins? Those cells become permanently fucked up and need to trigger apoptosis or be killed by your immune system. If those are cheap replaceable muscle cells like the Jaboids intended, you're in the clear. If they sprayed all the fuck over the place and, say, killed something more important that's harder to reproduce, perhaps you have....symptoms that last longer than 30 days.

Keep guinea pigging for a technology that's never made it successfully past animal trials unless the FDA lets them skip past. The common cold is such a horrible wasting disease we need immediate action; get jabbed every three months or you're gonna die!

 

[eDove]

Whoever is writing this article needs to be shot for their lack of cohesion and improper word usage. That was so irritating to read.

 

[SouthernBitchBob]

Feel free to provide a study that proves your assertion since it has not been demonstrated in any research of which I am aware related to any of the mRNA vaccines. Seems like nothing more than conjecture and supposition to me.

What study? mRNA has never made it past animal trials. Because it's woo-woo that doesn't clear the bar. Unless the FDA lets them skip trials because the Veree Deadlee Common Cold necessitates it.

Covid is a cold. Always was. Why in the fuck do you need Emergency Science Juice for a cold?

 

[Big Brown Schlub]

Remember the mild myocarditis meme?

Also am I the only dude here who somehow managed to avoid both the wacky science juice and catching the 'rona?

 

[Tour of Italy]

I wish it wasn’t recently revealed that the federal government spent billions of dollars on psychological warfare to try and convince people to take the shot.

It kind of makes any good-faith discussion about the underlying principles impossible.

Still, I have gotten COVID twice compared to a number of my vaxxed family members who have gotten it 3+ times in 2 years.

 

[m1ddl3m4rch]

@Manul Otocolobus how much is Pharma paying you, liar?

 

[Flan Handler]

So, in summary, anyone impacted by the vaccine saw it happen within 30 days of getting the vaccine. The spike protein, nor the mRNA are capable of staying in your body for more than 30 days. All the effects of the vaccine wane within 6 months, including its beneficial immunity. No one's DNA was permanently altered, ever. Nothing stays in your body. If something bad hasn't happened to you within the first 30 days after getting the vaccine, it's not going to happen.

What do you mean, “nothing stays in your body”? My father in law started collapsing within a few weeks of his second Moderna shot.

He was diagnosed first with vertigo, and then transverse myelitis. He got worse over the next few months and lost the ability to walk. TM is now a known side effect but was denied at the time.

He died of a heart attack 6 months after his Moderna shot and never got any improvement from the transverse myelitis. Nothing “cleared itself” from his system.

I realize you are trying to “science” here, but for people who have been injured or lost loved ones, do you think we haven’t had years of people like you condescendingly explain that what happened couldn’t have happened? Every fucking institution lined up to gaslight us about how what obviously happened was impossible.

 

[m1ddl3m4rch]

Feel free to provide facts with peer-reviewed, reasonable sources to refute what I have posted, retard.

You mad that people said no to your poison, liar? What motive do you have to peddle poison on this forum?

 

[m1ddl3m4rch]

I'm sorry for your loss, but your feelings don't override facts and data.

They do when it's your body and thus your choice. Sorry you have to deal with other people's medical rights. Sorry you have to deal with people telling you No.

 

[ToroidalBoat]

catching the 'rona?

I may have gotten the coof, but it could've just been an annual cold.

Also the first (and only) time I got a test, the result was negative.

 

[Echo_Ender]

The way I interpret these studies is that it's a matter of luck that so far no nasty consequences have been found, but there's still a lot that they haven't tested for definitively, as they say in the Nature paper itself.

It's not necessarily "Luck". There's a good chance that "Nasty consequences" have indeed been found, but on a small enough scale that Big Pharma and the Government have found ways to bury it.

They'll pay people/families of for silence, have corporate doctors claim it was caused by something else, say it was a pre-existing condition, ect. We'll probably never know the actual damage it caused.

Really, the entire mRNA concept is a bad idea, because it's playing with fire trying to vaccinate against something that evolves too fast.

I'll give a basic summary of what they're doing in simple terms:

Spoiler: Vaccine Sperging

So before they fucked with the definition of Vaccine, they were basically dead or severely weakened cells from the target Virus injected into you.

This basically taught your body how to fight that virus and create antibodies without you getting sick. It works fantastic on simple viruses that are slow to evolve and don't make any drastic changes.

This is how we basically wiped out Smallpox, Mumps, Tuberculosis, and a bunch of other deadly but simple viruses.

But on more complex viruses, this isn't effective. The Flu, Streptococcus, and the Common Cold are some examples.

The viruses evolve into new strains too fast for the antibodies you create from a vaccine to stay effective for long. Your body has to build white blood cells that learn what the virus vaguely looks like and how to hunt it.

This takes time. And most of the dead/weakened virus injected is cleared away by your body long before this happens.

In Flu vaccines, they tried making the "Weakened" virus part less weak so it'll last longer, but this often allows them to cause a full-blown infection. That's why the "I got the Flu when they gave me a Flu shot!" phenomenon is a real, fairly common complaint.

If they tried that with the Covid vaccine, the backlash would've been huge, so they tried something way more dangerous.

They spliced some of the virus' RNA into proteins, added some code for them to self-replicate for a while, and injected them.

In theory, this causes the body to think it's under attack by Covid and train itself to hunt the proteins Covid produces. The protein self-replicating makes it stay in your system long enough for your body to "Learn" to fight it properly.

This more or less works, but has two immediately negative effects:

• Your body thinks it's suffering a full-blown infection, so you get some terrible symptoms as it goes all out to fight the "Infection". Fever/Chills, headaches, muscle aches, and extreme fatigue are the most common and can be brutal.
• The proteins start spreading around your body as, until they degrade and stop self-replicating, they replicate faster than your body can filter them out.
• This causes some potentially terrible effects. They inevitably get into some of your tissues, usually muscles, and your body attacks that tissue, thinking it's infected. This could, in extremely rare but still possible cases, cause an autoimmune disorder where you immune system starts attacking healthy cells!
• If your body really falls behind in cleaning them out, which it might due to it using all your energy "Fighting an infection", they can clump up, causing blood clots and other blockages.

And the best part? Covid evolves it's RNA so fast that even this "Training" in your immune system will be ineffective in a few months. THEY KNEW THIS. This is why they want you to get "Boosters"

They were saying a year. Then six months. Now it's every 3 months. I've talked to an immunologist who thinks it's closer to a single month of effective protection, and that's mostly because the proteins make your immune system go full blast. Which is unhealthy for different reasons.

They really want you to forget that THE COMMON COLD is a Corona virus and mankind has survived it for millennia.

Because viruses evolve to become less severe. If they kill their hosts, they don't spread and they die out. That's why the obnoxious-but-nonlethal cold is everywhere, while the Bubonic Plague isn't.

What they should've done for Covid is to isolate and treat any SEVERE cases, while letting people naturally develop immunity to the weaker strains. That's "Herd Immunity" and farmers have successfully done it with livestock for a long time.

 

[Bagronkleton]

I'm sorry for your loss, but your feelings don't override facts and data. Just because there was a temporal correlation to what happened to your father-in-law does nothing to prove a casual relationship. Unless you have tests and data that definitively prove your assertions. Anyone who has any scientific training will tell you the same exact thing.

I'm going to take a more level-headed approach to the point they're trying to make: regardless of how it's framed, accurate or not, is beside the point.

It never should have been done in the first place. The social pressure, financial pressure, all the fuckery that went into coercing large amounts of people who, by and large, had no legitimate reason to take it.

That's the reason for the hatred, and any argument justifying it or perceived to justify it is viewed with the same level of disdain.

To emphasize again: it never should have been pushed in the way it was, and there should be severe punishments for all involved in pushing it.

 

[SSj_Ness (Yiffed)]

The "harmless protein" will be reported on again in 5 years when it's "discovered" to not be so harmless after all.

 

[Bagronkleton]

I get what youre saying, but unfortunately the two factors are intrinsically tied to each other in the manner used to execute mass vaccination.
You can take the neutral stance all you like, but you're gonna have to deal with the flack.

Medical science and the medical community at large was criminally bent, either by force or finance it doesn't matter, there's no denying that. You're gonna need that thick skin, just sayin'.

 

[Bagronkleton]

People need to discuss science on its own merits, the rest of it is of no concern to me. If people want to counter science with nonsense and garbage, that's fine with me, I'll just laugh at them because it just proves they are incapable of properly discussing a scientific topic in a rational manner. It makes them no better than the mindless bugmen that follow Xi. They are welcome to wallow in their ignorance and stupidity. They only makes fools of themselves, and anyone that agrees with their method of discussion need to take a long hard look in the mirror and decide if those are the people they want to associate themselves with, or would they rather discuss subjects like a thinking human being.

That's just the thing, where was this emphasis on discussing the science three years ago? People wanted to discuss it, you silly dense person. We were told take it or shut the fuck up. Now we're being told to talk only about specifically framed talking points or shut the fuck up because we're ignorant bugs.

You really just don't get it.

 

[Flan Handler]

I can't respect anyone that would choose to make up or ignore factual information just because it is inconvenient to their social or political perspective.

How do you know that your data is any good?

In my family’s case, the hospital staff exerted EXTREME pressure to not answer questions, insisted “the data” said my FIL’s death was completely unrelated to the shot, since his condition (transverse myelitis) was not a known side effect at the time.

They refused to put him in the vaccine adverse reporting database. As far as I know, no one formally linked his death to the vaccine. So how many other people did that happen to?

You seem to have a lot of faith in “data” that had a ton of corrupt political bullshit interfering in its collection and interpretation.

 

[m1ddl3m4rch]

That's just the thing, where was this emphasis on discussing the science three years ago? People wanted to discuss it, you silly dense person. We were told take it or shut the fuck up. Now we're being told to talk only about specifically framed talking points or shut the fuck up because we're ignorant bugs.

You really just don't get it.

He knows he lost the jab fight, and he's mad that the unwashed hoi polloi told their betters no.

I think in his mind if he debates and bullies his dissenters it retroactively makes him the winner.

 

[Irrational Exuberance]

Every single day Drain Todger is further vindicated...God what's it like to sperg out on the Internet and have everyone call you crazy only for medical articles to come out a week later reiterating everything you said almost verbatim? I imagine once or twice it's funny. By now I imagine the Drainy One as a crippling alcoholic who hates humanity.

Can't stop to think about it--the autism won't let you. It's always there, that tingling in the back of your mind - a "Speddy Sense", if you will - telling you that there are articles out there that the people here have to know about, even if they don't care--even if they mock you and give you negative stickers.

It's your blessing. It's your curse. You're Speder-Man.