Wuhan Coronavirus: Megathread - Got too big

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Probably a hotel paid for by the Red Cross.
Which brought up another question of mines: Travel is pretty much discouraged, but what if it is a case of "I'm moving to stay with my relative in another state to wait that out, because I'm not dealing with that". Allowed or no go?
Which is even more considering because while the weather outbreak happened, shelters stayed closed just because of the virus, leading to a fair amount of people losing their lives.
 
New York State lockdown extended to May 15. Mandatory mask order goes into effect tomorrow at 8 PM.
Archive
 
Hey, guess who's back? It's my nemesis, the Royal Lady fucking clock. And I swear it's somehow gotten uglier than last time! Who thought this was a good idea?! It's so fucking gaudy!

20200416_182118.jpg


A bit of googling turned up this




If you ignore the frequent advertisements for the EU and find the study you get this


With this helpful diagram

View attachment 1235066

It seems like the RNA isn't just loose inside the viral capsid, it's cleverer than that. The RNA is wrapped around a protein



I'm tempted to say 'MAYBE IF YOU INJECTED YOURSELF WITH SYNTHETIC VIRAL PARTICLES COMPOSED OF M,E AND S BUT NO RNA YOU'D DEVELOP ANTIBODIES TO S AND BECOME IMMUNE. YOU CAN PROBABLY FIND THE GENETIC SEQUENCES ON THE INTERNET. DO IT FAGGOT' but if I do that @EmuWarsVeteran will point out this is very irresponsible and will probably kill someone. So I'll burn a sockpuppet account posting it on Reddit instead. I'd feel pretty bad if one of the people in this thread died as a result of listening to my half-assed speculation but I don't give a toss about Redditors.

Oh no, no. That isn't irresponsible. It in fact is the basis for some of the newer vaccines. It's sound. So long as there's only proteins it can't infect and so long as it doesn't infect it won't kill no one. Well actually it doesn't replicate but technically it does kind of infect, it just infects with nothing, but the protein does trigger "infection" it just has nothing to actually push into the cell, which means I guess it could trigger a massive cytokine storm like any other allergen. But you know, it would literally be on par with an allergic reaction.

Protein based vaccines are currently being developped and tested for corona in fact. And other viri too. Long story short, issue is, they just many times don't work at all. It seems the immune system often times doesn't even realize viral particles have been added until they start infecting shit so it just completely ignores the vaccine and waits for it to get out through urine. So now we gotta learn how to get the immune system to get the memmo that we want it to fight against the vaccine and learn for the virus.

There is also the issue with triggering the immune system but not building actual immunity. Specially on virus with many different subtypes of proteins of every kind. It's fucking complicated and honestly it seems no one knows the depths to which these vaccines don't work sometimes because they're so new, they just don't work when they fucking please.

Basically protein based vaccines in general are really new and hard to make, so, they're working on it.
 

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Indian police officer's hand chopped off in sword attack during coronavirus lockdown (
Archive)
They are. Wages have stagnated in America since the 70s but cost of living keeps rising. There’s also income inequality and lowered social mobility.

Current exchange rates say that 1k Euro is about $1,090 USD, which is still pretty much at the poverty line in America. That barely covers rent in most places.

Thanks for the interesting conversation btw, I had no idea the cost of living is so much lower in Spain.
1. Wages have stagnated in America since the 70s but cost of living keeps rising. (Archive)
2. income inequality and lowered social mobility. (Archive)
1. Nadine's tweet: Source (Archive)
2.PiersMorgan's tweet: Source (Archive)
3.Paul's tweet: Source (Archive)
Everyone please go and watch this video right now:




It's basically about Dr. Luciano Gattinoni's findings on the two distinct groups of patients (Type L and Type H) of Covid-19 patients in Italy:



Actor Tom Hank's wife Rita Wilson (both of them just recovered from Covid-19): "They gave me chloroquine. It had such extreme side-effects. We are part of a study and we have donated our blood. We're waiting to hear if our anti-bodies are helpful in developing a vaccine but also we are able to donate plasma that can be used for other people who are suffering from the virus because we are immune."

Everyone please go and watch this video right now:
Actor Tom Hank's wife Rita Wilson (both of them just recovered from Covid-19): "They gave me chloroquine. It had such extreme side-effects. We are part of a study and we have donated our blood. We're waiting to hear if our anti-bodies are helpful in developing a vaccine but also we are able to donate plasma that can be used for other people who are suffering from the virus because we are immune." :
China (as the Chinese state) renounced all pretenses to sovereignty over Taiwan with the 1895 Shimonoseki peace treaty, years before the Peoples Republic of China or the Chinese Republic were formed.

The time has come to bring back the eight nations alliance to kick China's ass. As Austria-Hungarian empire is no longer around, maybe 2020 superpower India could take its place. Or Taiwan, or Korea (with sufficient guarantees even Kim Jong Un might be interested).:optimistic:
eight nations alliance (Archive)

Governor still refuses to let the mayor enforce shutdown orders. What the actual fuck. We’re going to see the deaths and cases skyrocket in the next two weeks here. Pray for me Kiwis because I’m within 10 miles of this one
South dakota meatpacking plant becomes the number one hotspot in America (Archive)
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The same WHO that lied to the world.
Bill's tweet: Source (Archive)
Rats war over lack of food how the virus shut down is effecting our skaven brothers.

Article mentions how they worried about the homeless and that's why they are focused on the rat issue....I think they will be fine.

I didnt see this posted yet but thought it was interesting when I bumped into it
Rats war over lack of food (Archive)
In other news, Mild Mannered Health Minister Hancock already a bit pissed off from Channel 4's stupid stunt of accusing the government of murdering old people got ratty with Robinson as the MSM finds chanting "when will you end the lockdown" endlessly after Keir Starmer suggested they talk about it the best course of action.

Really doesn't do the rapidly fading trust in the media any help whatsoever, and more people who only used to blindly believe the news, are starting to question the media's line of questioning.
1. Mild Mannered Health Minister Hancock (Archive)
2. stupid stunt (Archive)

goddamn even cnn is talking about this. sorry if it's been posted already, but I immediately thought of you nerds when I saw this. idk if it really means much for now, but I guess at least this gives us some vindication for going sperg on BLAST analyses a couple months ago when china was acting sketchy as fuck over giving people access to investigation lmao. it could also mean that they've found something interesting, even if it's not provable yet. idk, but it gives me some renewed interest.

though even if they can somehow pinpoint someone at the lab as being patient zero or something (not really sure how they're "taking a hard look at it"), i think it might not actually be possible to prove whether or not it's artificial. it seems like the virus has some evidence of a genetic recombination event, but given how bats frequently carry multiple viruses at the same time, and given that the exchanged bits both occur in bat viruses, such a thing could occur naturally. iirc the bit that appears inserted seemed convenient, but I guess that's how natural selection works.

if we wanted to bring that analysis back, maybe restriction enzymes with similar size and recognition sequence could at least give a hint of putative mechanism? or if it's crispr maybe off-target effects could be identified genome-wide or something? idk i'm more specialized on the computation end, we need to bring that otterly fellow back in here lmao.
US explores possibility that coronavirus started in Chinese lab, not a market (Archive)
Ya think? Ya think? Ya fucking think? We called this early on.

Did Xi Jinping deliberately sicken the world ? (Archive)
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Remember, archive everything !
 
that diagram isnt really usefull. i just see the virus envelope but no capsid (the capsid should be inside the envelope)

I think it does. The zoomed in section shows what looks like a phospholipid bilayer and the membrane glycoprotein protruding through it.

1587068121417.png


The paper says

At the relatively large underfocus value (4 μm) used for cryo-tomography, modifications of the images by the contrast transfer function of the microscope are expected. Therefore, to properly interpret these observations, we collected focal pairs of MHV and, for comparison with a pure lipid bilayer, of DOPC (1,2-dioleoyl-sn-glycero-3-phosphocholine) liposomes (see SI Text and Fig. S2). The analysis of these images showed that, in the defocus range examined (1, 2, 4, and 8 μm), the apparent thickness of the envelope does not change. The value for the MHV envelope thickness was confirmed (7.6 ± 0.4 nm, n = 101) and shown to be clearly larger than that of the DOPC lipid bilayers (4.2 ± 0.7 nm, n = 81). Furthermore, the inner peak of the bilaminar profile at 4 μm underfocus resolves in two at ≤2 μm underfocus (Fig. 4C).

This indicates the existence of an additional layer that would confer the virion envelope its remarkable thickness. We propose the inner lamina to be formed by the C-terminal domain of the M protein. Only a major component of the envelope, such as the M protein, could account for this general envelope feature. A topological model for the M protein of MHV has been proposed based on its hydrophobicity profile and on biochemical data (17–19). The protein consists of 3 transmembrane domains contained within its amino-terminal half, followed by a carboxy-terminal domain that is assumed to be located toward the interior of the virus. The carboxy-domain by itself has been found to associate with membranes (20), and most of it is resistant to protease treatment (18), indicating that this part is folded tightly onto the polar surface of the membrane. Assuming a globular conformation for the 9.5-kDa C-terminal domain, and a protein partial specific volume of 0.75 g/cm3, its diameter would be 2.8 nm. This is in good agreement with the thickness of the observed internal layer, which we estimate to be ≈3 nm based on the distance between peaks.

This paper has a schematic that shows the M proteins stick through the lipid bilayer, which is basically bits of the skin of the cell the virus was born chestbursting out of. Nature is fucking metal.

https://archive.vn/wip/qZ53E

1587068971906.png


Also, there's a cool visualization of viral particles bursting out of cells here

https://archive.vn/lVgNO

 
Which brought up another question of mines: Travel is pretty much discouraged, but what if it is a case of "I'm moving to stay with my relative in another state to wait that out, because I'm not dealing with that". Allowed or no go?
Which is even more considering because while the weather outbreak happened, shelters stayed closed just because of the virus, leading to a fair amount of people losing their lives.
They can't ban travel inside the US. It's not legal and with the exception of the Florida peninsula it's largely impossible to even try.
And under any standard, being homeless traveling to stay with family is emergency travel, not Chris Cuomo wondering around infected travel.

If you actually read the "orders" these governors have been signing you will find that most of them (when it comes to individual citizens) could be paraphrased as 'pretty please with sugar on top stay at home'.
With notable exceptions coming from governors that think they are dictators.
 
I feel bad about being inactive in this thread for so long. Things are in a weird place when your area is "locked down but not really" and so much is constantly in flux. I haven't done an update on the overall State of Alabama situation, so I should get that out of the way first.

April 13: Governor Ivey issued a Seventh Supplemental State of Emergency announcing the resumption of Pardon and Parole hearings, under conditions that reduce person-to-person interaction.

April 15: The State Public Health page for Chinese Virus™ info has been moved to a new location. You'll see it now contains links to .pdf files with daily case info, starting on 4/7.

April 16: Two new drive-thru testing sites have been opened in Adamsville and Montgomery.

I only have basic info for April 6th, but I'm including all the daily updates from the ADPH WuFlu page to make it easier for anyone who's interested in following the day-to-day curve. These updates are nice because they include age, race, sex, ethnicity and underlying condition info. The ArcGIS dashboard remains up for real-time status info.

I don't have "reported deaths" info for every single day, but I'm including it where I can for comparison to the "confirmed deaths" numbers since these two numbers move at different rates for obvious reasons. The comparison seems useful to have.

April 6th
Total confirmed cases: 2,006 (+165)
32 confirmed deaths (+1)

April 7th
Total confirmed cases: 2,229 (+223)
61 reported deaths
48 confirmed deaths (+17)

April 8th
Total confirmed cases: 2,505 (+276)
64 reported deaths (+3)
48 confirmed deaths (+0)

April 9th
Total confirmed cases: 2,881 (+376)
75 reported deaths (+11)
58 confirmed deaths (+10)

April 10th
Total confirmed cases: 3,022 (+141)
77 reported deaths (+2)
60 confirmed deaths (+12)

April 11th
Total confirmed cases: 3,274 (+252)
89 reported deaths (+12)
61 confirmed deaths (+1)

April 12th
Total confirmed cases: 3,592 (+318)
89 reported deaths (+0)
61 confirmed deaths (+1)

April 13th
Total confirmed cases: 3,808 (+216)
99 reported deaths (+10)
73 confirmed deaths: (+12)

April 14th
Total confirmed cases: 3,970 (+162)
105 reported deaths (+6)
76 confirmed deaths: (+3)

April 15th
Total confirmed cases: 4,245 (+275)
113 reported deaths (+8)
82 confirmed deaths (+6)

I'll refrain from going full blog, but the personal/family side of things isn't looking so hot right now. General stress over money and the political/economic implications of all this stuff has affected one member of the family much more than the rest, and the strain is showing. I'm making a guess that this is mostly due to said family member being extra susceptible to being put badly on tilt by stuff like this - political beliefs, personality factors, that sort of shit. I only mention this because today was the first time any real sign of serious trouble has arisen, and we can't be the only bunch seeing some amount of this.

Personally, I'm ready to see the lockdowns and shutdowns end.
 

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The poor of today live a hell of a lot better then the poor did in the 70s, and the poor have luxuries today that the middle class didnt have then, things like color TV and AC everywhere (and mobile internet), if my grandma is to be believed.
Reminds me of an argument I had with a goldbug once who was arguing that an iPhone cost $100 in 1990. Looking at one factor alone can lead to some absurd conclusions.
 
Fuck-up of the day:

I forgot it was Thursday. (Forgive me. Every day has just...melted into one lately.)

The collective of infants (at this point I am wondering if my cousin plans to come back for her bairns at any point) have been fed, bathed, jammie’d and have piled into one bed for story time.

We are ploughing though The Snail And The Whale when suddenly fireworks go off next door. Oh yes, it is clap time, I forgot. Oops.

I also forgot to bring the dog pack in from the garden before bath time, so when a rocket lands unexpectedly in our garden, the pack collectively bricks it, barges through the back door, and legs it in a mass furry panic upstairs...

...directly into a bed full of toddlers. It was like something out of the golden age of Looney Tunes.

I need a drink.
 
Trump is going to leave the decision on reopening up to the governors

https://archive.vn/dOPiz

The White House released new guidance late Thursday afternoon for states to reopen amid the coronavirus pandemic, leaving the decisions up to governors to make on a statewide or county-by-county level.

The guidance, which will be formally announced during a 6 p.m. news conference, doesn’t lay out a specific timeline for relaxing social distancing restrictions. It lists a set of criteria — such as testing and hospital capacity — for state leaders to use in making their decisions.

On a conference call earlier Thursday, Trump told governors, “You’re going to call your own shots,” according to a recording of the call obtained by The Washington Post. But he emphasized that the federal government will support the states.

Trump also told the governors they had “leeway” on testing, without getting into details.

“Testing is very interesting,” Trump said on the call. “There are some states where I think you can do with a lot less testing than other people are suggesting. ... Some are big believers in the testing. Some believe a little less.”

The guidelines suggest that before reopening, states should first see a decrease in confirmed covid-19 cases over a 14-day period. That suggestion is in line with the recommendations of public health experts, who have said that due to the virus’s 14-day incubation period, states should refrain from moving toward relaxing their restrictions until they have seen a sustained reduction in new cases for at least that long.

The White House plan also states that hospitals should be able to “treat all patients without crisis care” and have a “robust testing system in place for at-risk health care workers” before proceeding to a phased reopening

I can't really see how anyone can object to any of that, to be honest, and even if they did states don't have to follow it.
 
I don't know what to think anymore about this pandemic. I'm following this thread though. You guys are posting very useful and insightful information, so thank you! I wish I had useful input, but I don't.

All I know is that I want this pandemic to go away, I hope none of my family members or friends get it, and I want life to go back to normal.
 
I feel bad about being inactive in this thread for so long. Things are in a weird place when your area is "locked down but not really" and so much is constantly in flux. I haven't done an update on the overall State of Alabama situation, so I should get that out of the way first.

April 13: Governor Ivey issued a Seventh Supplemental State of Emergency announcing the resumption of Pardon and Parole hearings, under conditions that reduce person-to-person interaction.

April 15: The State Public Health page for Chinese Virus™ info has been moved to a new location. You'll see it now contains links to .pdf files with daily case info, starting on 4/7.

April 16: Two new drive-thru testing sites have been opened in Adamsville and Montgomery.

I only have basic info for April 6th, but I'm including all the daily updates from the ADPH WuFlu page to make it easier for anyone who's interested in following the day-to-day curve. These updates are nice because they include age, race, sex, ethnicity and underlying condition info. The ArcGIS dashboard remains up for real-time status info.

I don't have "reported deaths" info for every single day, but I'm including it where I can for comparison to the "confirmed deaths" numbers since these two numbers move at different rates for obvious reasons. The comparison seems useful to have.

April 6th
Total confirmed cases: 2,006 (+165)
32 confirmed deaths (+1)

April 7th
Total confirmed cases: 2,229 (+223)
61 reported deaths
48 confirmed deaths (+17)

April 8th
Total confirmed cases: 2,505 (+276)
64 reported deaths (+3)
48 confirmed deaths (+0)

April 9th
Total confirmed cases: 2,881 (+376)
75 reported deaths (+11)
58 confirmed deaths (+10)

April 10th
Total confirmed cases: 3,022 (+141)
77 reported deaths (+2)
60 confirmed deaths (+12)

April 11th
Total confirmed cases: 3,274 (+252)
89 reported deaths (+12)
61 confirmed deaths (+1)

April 12th
Total confirmed cases: 3,592 (+318)
89 reported deaths (+0)
61 confirmed deaths (+1)

April 13th
Total confirmed cases: 3,808 (+216)
99 reported deaths (+10)
73 confirmed deaths: (+12)

April 14th
Total confirmed cases: 3,970 (+162)
105 reported deaths (+6)
76 confirmed deaths: (+3)

April 15th
Total confirmed cases: 4,245 (+275)
113 reported deaths (+8)
82 confirmed deaths (+6)

I'll refrain from going full blog, but the personal/family side of things isn't looking so hot right now. General stress over money and the political/economic implications of all this stuff has affected one member of the family much more than the rest, and the strain is showing. I'm making a guess that this is mostly due to said family member being extra susceptible to being put badly on tilt by stuff like this - political beliefs, personality factors, that sort of shit. I only mention this because today was the first time any real sign of serious trouble has arisen, and we can't be the only bunch seeing some amount of this.

Personally, I'm ready to see the lockdowns and shutdowns end.

We all are, mate. We all are.

I don't know what to think anymore about this pandemic. I'm following this thread though. You guys are posting very useful and insightful information, so thank you! I wish I had useful input, but I don't.

All I know is that I want this pandemic to go away, I hope none of my family members or friends get it, and I want life to go back to normal.

And we all do.

Take care, everyone, and take some care of your mental state too. I forgot to actually bother saving memes for ya, but I got a japanese and an american meme that were shared by buddies today for ya. Don't forget to relax sometimes. Goodnight.


 
I don't know what to think anymore.....

I think this is the mental state some people in power are aiming for, tbh

On a serious note; the continuous data blast of numbers, speculation, theories and the need to keep cross referencing everything to make sure what your reading is not old news, bullshit etc can jelly the brain. It might even become a specific mental disorder with the combination of information/disinformation, stress, anxiety and paranoia .

PCSD - Post Covid Stress Disorder perhaps
 
That's hilarious. My bare minimum monthly bills are $3677 and that doesn't count food or anything else.
Spend less on candles.

Morgoth muses on 'The Tyranny Of Britain's PR Mind-benders'
It's interesting how similar this is to the hard left critic of capitalism using advertising agencies to create 'false consciousness' in the 90s. He even mentions Baudrillard's Hyperreality.
This geordie catches my feelings on the matter . It's the obvious astroturfed insincerity of it all. I feel like a stranger in my own country when I watch TV these days. Who is this shit aimed at? Who can watch this without having a visceral reaction against it?
OK I'll generally support the NHS, it's alright, and it's what we've got. But fuck your stupid heavyhanded manipulation.

Ya think? Ya think? Ya fucking think? We called this early on.

Yep. My personal opinion based on nothing more than balance of probablities, not proof.
- Accidental Lab escape of a virus they were studying. Maybe just collected from bat shit, maybe tinkered with.
- Chinese realised what they were dealing with , and what the danger was.
- Initially they lied and covered up out of instinct.
- At some point they made sure that it was deliberately spread around their main geopolitical rivals. Because, why wouldn't they?
- Continue to spread confusion and propaganda in different directions.
- Hope to come out ahead relatively once the dust settles.

I think most people in this thread agree with this narrative? But are we just an echo chamber, and are we remotely representative of the outside world?
 
Look, I've tried very hard to contain my thoughts about the way the US has been handling this. I just can't contain it anymore.

Is there a point in which you think, despite how rabidly #MAGA you might be, that Donald Trump is "not quite there"?

Mass graves in New York? #MAGA

Being modern-day Pirates? #MAGA

Reopening your country, before you've 'flattened the curve'? #MAGA
 
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